Quantitative analysis of unruptured intracranial aneurysm wall thickness and enhancement using 7T high resolution, black blood magnetic resonance imaging

2021 ◽  
pp. neurintsurg-2021-017688
Author(s):  
Xinke Liu ◽  
Junqiang Feng ◽  
Zhixin Li ◽  
Zihao Zhang ◽  
Qiang Zhang ◽  
...  
Keyword(s):  
Intracranial Aneurysm ◽  
Wall Thickness ◽  
Signal Intensity ◽  
Spin Echo ◽  
Fast Spin Echo ◽  
Black Blood ◽  
Post Contrast ◽  
Isotropic Resolution ◽  
Aneurysm Size ◽  
Aneurysm Wall

BackgroundThis study was performed to quantify intracranial aneurysm wall thickness (AWT) and enhancement using 7T MRI, and their relationship with aneurysm size and type.Methods27 patients with 29 intracranial aneurysms were included. Three-dimensional T1 weighted pre‐ and post-contrast fast spin echo with 0.4 mm isotropic resolution was used. AWT was defined as the full width at half maximum on profiles of signal intensity across the aneurysm wall on pre-contrast images. Enhancement ratio (ER) was defined as the signal intensity of the aneurysm wall over that of the brain parenchyma. The relationships between AWT, ER, and aneurysm size and type were investigated.Results7T MRI revealed large variations in AWT (range 0.11–1.24 mm). Large aneurysms (>7 mm) had thicker walls than small aneurysms (≤7 mm) (0.49±0.05 vs 0.41±0.05 mm, p<0.001). AWT was similar between saccular and fusiform aneurysms (p=0.546). Within each aneurysm, a thicker aneurysm wall was associated with increased enhancement in 28 of 29 aneurysms (average r=0.65, p<0.05). Thicker walls were observed in enhanced segments (ER >1) than in non-enhanced segments (0.53±0.09 vs 0.38±0.07 mm, p<0.001).ConclusionImproved image quality at 7T allowed quantification of intracranial AWT and enhancement. A thicker aneurysm wall was observed in larger aneurysms and was associated with stronger enhancement.

scholarly journals Relationship between aneurysm wall enhancement and conventional risk factors in patients with unruptured intracranial aneurysms: A black-blood MRI study

2016 ◽  
Vol 22 (5) ◽  
pp. 501-505 ◽  
Author(s):  
Peng Liu ◽  
Haikun Qi ◽  
Aihua Liu ◽  
Xianli Lv ◽  
Yuhua Jiang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Multivariate Logistic Regression Analysis ◽  
Black Blood ◽  
Mr Images ◽  
Post Contrast ◽  
Aneurysm Size ◽  
Aneurysm Wall ◽  
Wilcoxon Rank Sum Test ◽  
Unruptured Intracranial Aneurysms ◽  
Black Blood Imaging

Background and purpose Aneurysmal wall enhancement (AWE) has emerged as a new possible biomarker for depicting inflammation of the intracranial aneurysm (IA). However, the relationships of AWE with other risk factors are still unclear for unruptured IA. The purpose of this study was to investigate the association between AWE and other risk metrics. Methods Forty-eight patients with unruptured saccular IAs diagnosed by digital subtraction angiography were recruited to undergo magnetic resonance (MR) black-blood imaging. AWE was evaluated using the pre- and post-contrast black-blood MR images. Univariate and multivariate logistic regression analysis was performed to investigate the association of AWE with other risk factors, including size, maximal neck width, parent vessel diameter, location, multiplicity, daughter sacs and other clinical factors. The prevalence of AWE in each ISUIA grade was reported and compared by Wilcoxon rank sum test. Results In total, 61 aneurysms were detected in 48 patients. Aneurysm size was found to be an independent risk factor associated with AWE (OR 2.46 per mm increase, 95% CI 1.34–4.51; p = 0.004). Patient age was independently and inversely associated with AWE (OR 0.898 per year increase, 95% CI 0.812–0.994; p = 0.037). Higher prevalence of AWE was observed in larger aneurysms (12%, 71.4%, 100%, and 100% of ISUIA grade 1–4 IAs have AWE, respectively). Notably, 12% of small IAs (size <7 mm) exhibited AWE. The IAs with AWE had significant higher ISUIA grade than the IAs without ( p < 0.001, Wilcoxon rank sum test). Conclusions The wall enhancement in contrast-enhanced black-blood MR images was independently associated with aneurysm size in unruptured IAs. However, some small unruptured aneurysms did exhibit wall enhancement, suggesting that AWE may provide additional aneurysm instability information to improve current size-based rupture risk evaluation metrics.

scholarly journals Improvement of the Diagnostic Performance of Facial Neuritis Using Contrast-Enhanced 3D T1 Black-Blood Imaging: Comparison with Contrast-Enhanced 3D T1-Spoiled Gradient-Echo Imaging

2021 ◽  
Vol 10 (9) ◽  
pp. 1850
Author(s):  
Seun-Ah Lee ◽  
Sang-Won Jo ◽  
Suk-Ki Chang ◽  
Ki-Han Kwon
Keyword(s):  
Quantitative Analysis ◽  
Diagnostic Performance ◽  
Spin Echo ◽  
Fast Spin Echo ◽  
Black Blood ◽  
Gradient Echo ◽  
Diagnostic Confidence ◽  
Contrast Enhanced ◽  
Black Blood Imaging ◽  
Spoiled Gradient Echo

This study aims to investigate the diagnostic ability of the contrast-enhanced 3D T1 black-blood fast spin-echo (T1 BB-FSE) sequence compared with the contrast-enhanced 3D T1-spoiled gradient-echo (CE-GRE) sequence in patients with facial neuritis. Forty-five patients with facial neuritis who underwent temporal bone MR imaging, including T1 BB-FSE and CE-GRE imaging, were examined. Two reviewers independently assessed the T1 BB-FSE and CE-GRE images in terms of diagnostic performance, and qualitative (diagnostic confidence and visual asymmetric enhancement) and quantitative analysis (contrast-enhancing lesion extent of the canalicular segment of the affected facial nerve (LEC) and the affected side-to-normal signal intensity ratio (rSI)). The AUCs of each reviewer, and the sensitivity and accuracy of T1 BB-FSE were significantly superior to those of CE-GRE (p < 0.05). Regarding diagnostic confidence and visual asymmetric enhancement, T1 BB-FSE tended to be rated greater than CE-GRE (p < 0.05). Additionally, in quantitative analysis, LEC and rSI of the canalicular segment on T1 BB-FSE were larger than those on CE-GRE (p < 0.05). The T1 BB-FSE sequence was significantly superior to the CE-GRE sequence, with more conspicuous lesion visualization in terms of both qualitative and quantitative aspects in patients with facial neuritis.

Black blood magnetic resonance angiography with Dy-DTPA polymer: Effect on arterial intraluminal signal intensity, lumen diameter, and wall thickness

1998 ◽  
Vol 8 (5) ◽  
pp. 1051-1059 ◽  
Author(s):  
William B. Eubank ◽  
Udo P. Schmiedl ◽  
Chun Yuan ◽  
Christopher D. V. Black ◽  
Kenneth E. Kellar ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Angiography ◽  
Wall Thickness ◽  
Signal Intensity ◽  
Lumen Diameter ◽  
Black Blood

scholarly journals 3D Fast Spin-Echo T1 Black-Blood Imaging for the Diagnosis of Cervical Artery Dissection

2012 ◽  
Vol 34 (9) ◽  
pp. E103-E106 ◽  
Author(s):  
M. Edjlali ◽  
P. Roca ◽  
C. Rabrait ◽  
O. Naggara ◽  
C. Oppenheim
Keyword(s):  
Spin Echo ◽  
Fast Spin Echo ◽  
Artery Dissection ◽  
Cervical Artery Dissection ◽  
Black Blood ◽  
Black Blood Imaging ◽  
Cervical Artery ◽  
Blood Imaging ◽  
Fast Spin

scholarly journals High Signal Intensity of Fat on Fast Spin Echo Imaging

2000 ◽  
Vol 56 (10) ◽  
pp. 1269-1275
Author(s):  
Akio OGURA ◽  
Masaru YAMAZAKI ◽  
Takaharu HONGOH ◽  
Hiroshi INOUE ◽  
Akihiro ISHIKURO
Keyword(s):  
Signal Intensity ◽  
Spin Echo ◽  
High Signal Intensity ◽  
Fast Spin Echo ◽  
High Signal ◽  
Fast Spin

scholarly journals Effect of Aneurysm and Patient Characteristics on Intracranial Aneurysm Wall Thickness

2021 ◽  
Vol 8 ◽  
Author(s):  
Jason M. Acosta ◽  
Anne F. Cayron ◽  
Nicolas Dupuy ◽  
Graziano Pelli ◽  
Bernard Foglia ◽  
...  
Keyword(s):  
Intracranial Aneurysm ◽  
Wall Thickness ◽  
Positive Family History ◽  
Patient Characteristics ◽  
Western World ◽  
University Hospitals ◽  
Thickness Uniformity ◽  
Neck Size ◽  
Aneurysm Wall

Background: The circle of Willis is a network of arteries allowing blood supply to the brain. Bulging of these arteries leads to formation of intracranial aneurysm (IA). Subarachnoid hemorrhage (SAH) due to IA rupture is among the leading causes of disability in the western world. The formation and rupture of IAs is a complex pathological process not completely understood. In the present study, we have precisely measured aneurysmal wall thickness and its uniformity on histological sections and investigated for associations between IA wall thickness/uniformity and commonly admitted risk factors for IA rupture.Methods: Fifty-five aneurysm domes were obtained at the Geneva University Hospitals during microsurgery after clipping of the IA neck. Samples were embedded in paraffin, sectioned and stained with hematoxylin-eosin to measure IA wall thickness. The mean, minimum, and maximum wall thickness as well as thickness uniformity was measured for each IA. Clinical data related to IA characteristics (ruptured or unruptured, vascular location, maximum dome diameter, neck size, bottleneck factor, aspect and morphology), and patient characteristics [age, smoking, hypertension, sex, ethnicity, previous SAH, positive family history for IA/SAH, presence of multiple IAs and diagnosis of polycystic kidney disease (PKD)] were collected.Results: We found positive correlations between maximum dome diameter or neck size and IA wall thickness and thickness uniformity. PKD patients had thinner IA walls. No associations were found between smoking, hypertension, sex, IA multiplicity, rupture status or vascular location, and IA wall thickness. No correlation was found between patient age and IA wall thickness. The group of IAs with non-uniform wall thickness contained more ruptured IAs, women and patients harboring multiple IAs. Finally, PHASES and ELAPSS scores were positively correlated with higher IA wall heterogeneity.Conclusion: Among our patient and aneurysm characteristics of interest, maximum dome diameter, neck size and PKD were the three factors having the most significant impact on IA wall thickness and thickness uniformity. Moreover, wall thickness heterogeneity was more observed in ruptured IAs, in women and in patients with multiple IAs. Advanced medical imaging allowing in vivo measurement of IA wall thickness would certainly improve personalized management of the disease and patient care.

MRI Assessment of Hippocampal Sclerosis

2005 ◽  
Vol 18 (3) ◽  
pp. 357-363
Author(s):  
A. Lefkopoulos ◽  
A. Tzinas ◽  
E. Papadopoulou ◽  
A. Haritanti ◽  
D. Karanikolas ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
Signal Intensity ◽  
Hippocampal Formation ◽  
Spin Echo ◽  
Hippocampal Sclerosis ◽  
High Sensitivity ◽  
Cost Effective ◽  
Inversion Recovery ◽  
Fast Spin Echo ◽  
Transverse Spin

Hippocampal Sclerosis (HS) is the most common cause of refractory temporal lobe epilepsy in adults. The aim of our study was to evaluate the diagnostic accuracy of conventional MRI sequences in HS and devise a cost-effective protocol of choice. Forty-eight patients, 26 men and 22 women, aged 16–55 years (mean age 29 years) with seizures refractory to medical treatment were evaluated by MR imaging. Hippocampal formation was assessed by transverse spin-echo (SE) T1-weighted (WI) and fast spin-echo (FSE) T2-WI sequences and by coronal Fluid Attenuated Inversion Recovery (FLAIR) and Inversion Recovery (IR) images. Increased signal intensity in FLAIR (93.2%), hippocampal atrophy (84.8%) and decreased signal intensity in IR images (72.7%) were the most common pathological findings of HS, while loss of the ipsilateral temporal lobe gray/white matter demarcation (66,7%) and amygdala sclerosis (15.1%) were encountered less frequently. FLAIR sequence was found to be more sensitive than FSE T2-WI in detecting HS. Thin coronal images were particularly helpful in assessing hippocampal formation, while IR images were additionally useful for the detection of possible co-existent cortical abnormalities. A brief review of the imaging findings of HS in more recent MR sequences is also made, though emphasizing that conventional SE T1-WI, FSE T2-WI, FLAIR and IR sequences, with a total examination duration of less than eight minutes, provide high sensitivity and specificity in the assessment of HS.

scholarly journals Comparison of Gated and Ungated Black-Blood Fast Spin-echo MRI of Carotid Vessel Wall at 3T

2016 ◽  
Vol 15 (3) ◽  
pp. 266-272 ◽  
Author(s):  
Chengcheng ZHU ◽  
Martin J GRAVES ◽  
Umar SADAT ◽  
Victoria E YOUNG ◽  
Jonathan H GILLARD ◽  
...  
Keyword(s):  
Vessel Wall ◽  
Spin Echo ◽  
Fast Spin Echo ◽  
Black Blood ◽  
Carotid Vessel Wall ◽  
Fast Spin ◽  
Carotid Vessel
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