Currently, embedded systems make use of large, multiprocessing systems on chip integrating complex application software running on the different processors in close interaction with the application-specific hardware. These systems demand new modeling, simulation, and performance estimation tools and methodologies for system architecture evaluation and design exploration. Recently approved as IEEE 1666 standard, SystemC has proven to be a powerful language for system modeling and simulation. In this chapter, SCoPE, a SystemC framework for platform modeling, SW source-code behavioral simulation and performance estimation of embedded systems is presented. Using SCoPE, the application SW running on the different processors of the platform can be simulated efficiently in close interaction with the rest of the platform components. In this way, fast and sufficiently accurate performance metrics are obtained for design-space exploration.