The Role of Static Night Splinting After Contracture Release for Dupuytren’s Disease: A Preliminary Recommendation Based on Clinical Cases

We compared the incidence of significant Dupuytren’s disease in men across occupational social classes in England and Wales, using data from the National Morbidity Survey. We found that manual occupational social class was not associated with an increased incidence of Dupuytren’s disease. In fact, the incidence rates of Dupuytren’s disease in the elderly were higher in non-manual than in manual social classes.

Download Full-text

Dupuytren’s Disease Occurring after a Surgical Injury to the Hand

Journal of Hand Surgery (European Volume) ◽

10.1016/s0266-7681(96)80050-7 ◽

1996 ◽

Vol 21 (4) ◽

pp. 481-483 ◽

Cited By ~ 8

Author(s):

M. LANZETTA ◽

W. A. MORRISON

Keyword(s):

The Body ◽

Dupuytren’S Disease ◽

Surgical Trauma ◽

Dupuytren's Disease ◽

Contralateral Hand ◽

Similar Operation ◽

Surgical Injury ◽

Clinical Cases

We report three clinical cases in which Dupuytren’s disease was triggered by surgical trauma. All patients developed the contracture between 3 weeks and 3 months after operation for unrelated / pathology of the hand. They had significant swelling of the hand postoperatively, preventing full mobilization. They did not have a strong diathesis for the disease. Since the appearance of the contracture, they have not developed the disease in the contralateral hand or anywhere else in the body. In one case, a similar operation on the contralateral hand has not provoked onset of the disease.

Download Full-text

An Investigation into the Role of Inflammatory Cells in Dupuytren’s Disease

Journal of Hand Surgery (European Volume) ◽

10.1016/0266-7681(91)90051-o ◽

1991 ◽

Vol 16 (3) ◽

pp. 267-271 ◽

Cited By ~ 30

Author(s):

J. G. ANDREW ◽

S. M. ANDREW ◽

A. ASH ◽

B. TURNER

Keyword(s):

Inflammatory Cells ◽

Dupuytren’S Disease ◽

Dupuytren’S Contracture ◽

Palmar Fascia ◽

Dupuytren's Disease ◽

Dupuytren's Contracture ◽

Microvascular Changes ◽

Macrophage Marker ◽

Fibrotic Diseases

An immunohistochemical study was performed on nodules excised from the palmar fascia of patients with Dupuytren’s contracture. In cellular nodules, antibodies to actin (used as a marker for myofibroblasts), desmin, vimentin, Mac 387 (a macrophage marker) and leucocyte common antigen were used. A correlation was demonstrated between the numbers of macrophages and the presence of myofibroblasts. The presence of myofibroblasts is generally considered to indicate the active stage of the disease. Inflammatory cells other than macrophages were largely absent from the nodules, although lymphocytes were frequent in the tissue around the nodules. Microvascular changes were prominent in the nodules and pericyte proliferation was observed around occluded capillaries. Release of growth factors from macrophages may be important in Dupuytren’s contracture, as is the case in other fibrotic diseases. The possible role of macrophages in the aetiology of Dupuytren’s disease is discussed.

Download Full-text

Update on the role of molecular factors and fibroblasts in the pathogenesis of Dupuytren’s disease

Journal of Cell Communication and Signaling ◽

10.1007/s12079-016-0331-0 ◽

2016 ◽

Vol 10 (4) ◽

pp. 315-330 ◽

Cited By ~ 1

Author(s):

Massimiliano Tripoli ◽

Adriana Cordova ◽

Francesco Moschella

Keyword(s):

Dupuytren’S Disease ◽

Dupuytren's Disease

Download Full-text

Role of the HLA System in the Pathogenesis of Dupuytren's Disease

Hand ◽

10.1007/s11552-009-9255-y ◽

2010 ◽

Vol 5 (3) ◽

pp. 241-250 ◽

Cited By ~ 11

Author(s):

Sara McCarty ◽

Farhatullah Syed ◽

Ardeshir Bayat

Keyword(s):

Dupuytren’S Disease ◽

Dupuytren's Disease ◽

Hla System

Download Full-text

Dupuytren’s disease: limited fasciectomy, night splinting, and hand exercises—long-term results

European Journal of Orthopaedic Surgery & Traumatology ◽

10.1007/s00590-018-2340-6 ◽

2018 ◽

Vol 29 (2) ◽

pp. 349-355

Author(s):

Dimitrios Kitridis ◽

Paraskevi Karamitsou ◽

Iraklis Giannaros ◽

Nikolaos Papadakis ◽

Chris Sinopidis ◽

...

Keyword(s):

Dupuytren’S Disease ◽

Long Term Results ◽

Dupuytren's Disease ◽

Limited Fasciectomy ◽

Night Splinting ◽

Hand Exercises

Download Full-text

Scanning Electron Microscopy of Palmar Fascia in Dupuytren’s Disease of Advanced Stage

Traumatology and Orthopedics of Russia ◽

10.21823/2311-2905-2019-25-2-150-156 ◽

2019 ◽

Vol 25 (2) ◽

pp. 150-156

Author(s):

N. A. Shchudlo ◽

T. A. Stupina ◽

M. M. Shchudlo

Keyword(s):

Dupuytren’S Disease ◽

Palmar Fascia ◽

Dupuytren's Disease ◽

Palmar Aponeurosis ◽

Medical Histories ◽

Fibers Orientation ◽

Disease Stages ◽

Grade Iii ◽

Scanning Electron

Relevance. Dupuytren’s disease (palmar fascial fibromatosis) affects primarily palmar and digital fascia and results in progressive wrist deformity in many patients and often with bilateral involvement. Absence of corresponding data on the patients with severe wrist deformities along with their treatment issues is the ground for targeted research of pathomorphology of advanced disease stages.Purpose of the study — to identify features of ultrastructure of fibromatosis nodules and bands in palmar aponeurosis of patients with Dupuytren’s disease of grade III-IV.Materials and Methods. The authors analyzed medical histories and surgical material of 20 patients aging 42–77 years. Segments from medial portion of pretendinous cord of IV digit were cut for examination under scanning electron microscope (JSM-840, Jeol, Japan).Results. Irrespective of disease history (from 1 to 20 years) fibrbous-fibrillar network and fine cylindrical collagen fibers prevailed in nodules of pretendinous cord which formed semicircular and circular end coils. Empty lacunae, functionally active fibroblasts and close cellular pairs were observed in nodules. Bands differed from nodules by lesser cellularity and less content of fine fibers, orientation of thick fibers mainly along one axis, straightening segments of undulated twisting and separate twisted and tightly interwoven fiber fragments.Conclusion. In Dupuytren’s disease of grade III-IV nodules maintain the role of active contractile centers. Despite relatively small cellularity of pathologically altered tissues there is a potential for progressing, propagation and recurrence of fibromatosis.

Download Full-text