scholarly journals Role of the HLA System in the Pathogenesis of Dupuytren's Disease

Hand ◽  
2010 ◽  
Vol 5 (3) ◽  
pp. 241-250 ◽  
Author(s):  
Sara McCarty ◽  
Farhatullah Syed ◽  
Ardeshir Bayat
Keyword(s):  
Dupuytren’S Disease ◽  
Dupuytren's Disease ◽  
Hla System

The Role of Manual Occupation in the Aetiology of Dupuytren’s Disease in Men in England and Wales

2004 ◽  
Vol 29 (1) ◽  
pp. 12-14 ◽  
Author(s):  
A. A. KHAN ◽  
O. J. RIDER ◽  
C. U. JAYADEV ◽  
C. HERAS-PALOU ◽  
H. GIELE ◽  
...  
Keyword(s):  
The Elderly ◽  
Incidence Rates ◽  
Social Classes ◽  
Dupuytren’S Disease ◽  
Dupuytren's Disease ◽  
England And Wales ◽  
Occupational Social Class ◽  
Using Data ◽  
Manual Occupation

We compared the incidence of significant Dupuytren’s disease in men across occupational social classes in England and Wales, using data from the National Morbidity Survey. We found that manual occupational social class was not associated with an increased incidence of Dupuytren’s disease. In fact, the incidence rates of Dupuytren’s disease in the elderly were higher in non-manual than in manual social classes.

An Investigation into the Role of Inflammatory Cells in Dupuytren’s Disease

1991 ◽  
Vol 16 (3) ◽  
pp. 267-271 ◽  
Author(s):  
J. G. ANDREW ◽  
S. M. ANDREW ◽  
A. ASH ◽  
B. TURNER
Keyword(s):  
Inflammatory Cells ◽  
Dupuytren’S Disease ◽  
Dupuytren’S Contracture ◽  
Palmar Fascia ◽  
Dupuytren's Disease ◽  
Dupuytren's Contracture ◽  
Microvascular Changes ◽  
Macrophage Marker ◽  
Fibrotic Diseases

An immunohistochemical study was performed on nodules excised from the palmar fascia of patients with Dupuytren’s contracture. In cellular nodules, antibodies to actin (used as a marker for myofibroblasts), desmin, vimentin, Mac 387 (a macrophage marker) and leucocyte common antigen were used. A correlation was demonstrated between the numbers of macrophages and the presence of myofibroblasts. The presence of myofibroblasts is generally considered to indicate the active stage of the disease. Inflammatory cells other than macrophages were largely absent from the nodules, although lymphocytes were frequent in the tissue around the nodules. Microvascular changes were prominent in the nodules and pericyte proliferation was observed around occluded capillaries. Release of growth factors from macrophages may be important in Dupuytren’s contracture, as is the case in other fibrotic diseases. The possible role of macrophages in the aetiology of Dupuytren’s disease is discussed.

scholarly journals Update on the role of molecular factors and fibroblasts in the pathogenesis of Dupuytren’s disease

2016 ◽  
Vol 10 (4) ◽  
pp. 315-330 ◽  
Author(s):  
Massimiliano Tripoli ◽  
Adriana Cordova ◽  
Francesco Moschella
Keyword(s):  
Dupuytren’S Disease ◽  
Dupuytren's Disease

scholarly journals Scanning Electron Microscopy of Palmar Fascia in Dupuytren’s Disease of Advanced Stage

2019 ◽  
Vol 25 (2) ◽  
pp. 150-156
Author(s):  
N. A. Shchudlo ◽  
T. A. Stupina ◽  
M. M. Shchudlo
Keyword(s):  
Dupuytren’S Disease ◽  
Palmar Fascia ◽  
Dupuytren's Disease ◽  
Palmar Aponeurosis ◽  
Medical Histories ◽  
Fibers Orientation ◽  
Disease Stages ◽  
Grade Iii ◽  
Scanning Electron

Relevance. Dupuytren’s disease (palmar fascial fibromatosis) affects primarily palmar and digital fascia and results in progressive wrist deformity in many patients and often with bilateral involvement. Absence of corresponding data on the patients with severe wrist deformities along with their treatment issues is the ground for targeted research of pathomorphology of advanced disease stages.Purpose of the study — to identify features of ultrastructure of fibromatosis nodules and bands in palmar aponeurosis of patients with Dupuytren’s disease of grade III-IV.Materials and Methods. The authors analyzed medical histories and surgical material of 20 patients aging 42–77 years. Segments from medial portion of pretendinous cord of IV digit were cut for examination under scanning electron microscope (JSM-840, Jeol, Japan).Results. Irrespective of disease history (from 1 to 20 years) fibrbous-fibrillar network and fine cylindrical collagen fibers prevailed in nodules of pretendinous cord which formed semicircular and circular end coils. Empty lacunae, functionally active fibroblasts and close cellular pairs were observed in nodules. Bands differed from nodules by lesser cellularity and less content of fine fibers, orientation of thick fibers mainly along one axis, straightening segments of undulated twisting and separate twisted and tightly interwoven fiber fragments.Conclusion. In Dupuytren’s disease of grade III-IV nodules maintain the role of active contractile centers. Despite relatively small cellularity of pathologically altered tissues there is a potential for progressing, propagation and recurrence of fibromatosis.

scholarly journals The Role of Stem Cells in Dupuytren’s Disease

2018 ◽  
Vol 6 (5) ◽  
pp. e1777 ◽  
Author(s):  
Kirin Tan ◽  
Aaron H. J. Withers ◽  
Swee T. Tan ◽  
Tinte Itinteang
Keyword(s):  
Stem Cells ◽  
Dupuytren’S Disease ◽  
Dupuytren's Disease

The Effect of Steroids on Dupuytren’s Disease: Role of Programmed Cell Death

2002 ◽  
Vol 27 (3) ◽  
pp. 270-273 ◽  
Author(s):  
R. M. D MEEK ◽  
S. McLELLAN ◽  
J REILLY ◽  
J. F. CROSSAN
Keyword(s):  
Cell Death ◽  
Inflammatory Cells ◽  
Fascia Lata ◽  
Dupuytren’S Disease ◽  
Fibroblast Proliferation ◽  
Palmar Fascia ◽  
Dupuytren's Disease ◽  
Proliferation And Apoptosis ◽  
And Control

This study compared the rates of proliferation and apoptosis of cells within nodules of Dupuytren’s disease and nodules from patients that had been injected preoperatively with steroid (Depo-Medrone). It also compared the effects of steroids in apoptosis in cultured Dupuytren’s cells and control fibroblasts from palmar fascia and fascia lata. Steroids reduced the rate of fibroblast proliferation and increased the rate of apoptosis of both fibroblasts and inflammatory cells in Dupuytren’s tissue. Steroids also produced apoptosis of cultured Dupuytren’s cells but not of palmar fascia and fascia lata cells.

The role of transforming growth factor beta in Dupuytren's disease

1996 ◽  
Vol 21 (2) ◽  
pp. 210-215 ◽  
Author(s):  
Marie A. Badalamente ◽  
Steven P. Sampson ◽  
Lawrence C. Hurst ◽  
Andrew Dowd ◽  
Kenji Miyasaka
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Dupuytren’S Disease ◽  
Dupuytren's Disease ◽  
Growth Factor Beta
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