Spectral Discrimination Thresholds Comparing Audio and Haptics for Complex Stimuli

Author(s):  
Lorenzo Picinali ◽  
Christopher Feakes ◽  
Davide A. Mauro ◽  
Brian F. G. Katz
1998 ◽  
Vol 41 (3) ◽  
pp. 538-548 ◽  
Author(s):  
Sean C. Huckins ◽  
Christopher W. Turner ◽  
Karen A. Doherty ◽  
Michael M. Fonte ◽  
Nikolaus M. Szeverenyi

Functional Magnetic Resonance Imaging (fMRI) holds exciting potential as a research and clinical tool for exploring the human auditory system. This noninvasive technique allows the measurement of discrete changes in cerebral cortical blood flow in response to sensory stimuli, allowing determination of precise neuroanatomical locations of the underlying brain parenchymal activity. Application of fMRI in auditory research, however, has been limited. One problem is that fMRI utilizing echo-planar imaging technology (EPI) generates intense noise that could potentially affect the results of auditory experiments. Also, issues relating to the reliability of fMRI for listeners with normal hearing need to be resolved before this technique can be used to study listeners with hearing loss. This preliminary study examines the feasibility of using fMRI in auditory research by performing a simple set of experiments to test the reliability of scanning parameters that use a high resolution and high signal-to-noise ratio unlike that presently reported in the literature. We used consonant-vowel (CV) speech stimuli to investigate whether or not we could observe reproducible and consistent changes in cortical blood flow in listeners during a single scanning session, across more than one scanning session, and in more than one listener. In addition, we wanted to determine if there were differences between CV speech and nonspeech complex stimuli across listeners. Our study shows reproducibility within and across listeners for CV speech stimuli. Results were reproducible for CV speech stimuli within fMRI scanning sessions for 5 out of 9 listeners and were reproducible for 6 out of 8 listeners across fMRI scanning sessions. Results of nonspeech complex stimuli across listeners showed activity in 4 out of 9 individuals tested.


Author(s):  
Vanessa Meterko ◽  
Glinda Cooper

AbstractPsychological heuristics are an adaptive part of human cognition, helping us operate efficiently in a world full of complex stimuli. However, these mental shortcuts also have the potential to undermine the search for truth in a criminal investigation. We reviewed 30 social science research papers on cognitive biases in criminal case evaluations (i.e., integrating and drawing conclusions based on the totality of the evidence in a criminal case), 18 of which were based on police participants or an examination of police documents. Only two of these police participant studies were done in the USA, with the remainder conducted in various European countries. The studies provide supporting evidence that lay people and law enforcement professionals alike are vulnerable to confirmation bias, and there are other environmental, individual, and case-specific factors that may exacerbate this risk. Six studies described or evaluated the efficacy of intervention strategies, with varying evidence of success. Further research, particularly in the USA, is needed to evaluate different approaches to protect criminal investigations from cognitive biases.


2020 ◽  
Author(s):  
Ramesh K. Jha ◽  
Allison Yankey ◽  
Kalifa Shabazz ◽  
Leslie Naranjo ◽  
Nileena Velappan ◽  
...  

ABSTRACTWhile natural protein-protein interactions have evolved to be induced by complex stimuli, rational design of interactions that can be switched-on-demand still remain challenging in the protein design world. Here, we demonstrate a computationally redesigned natural interface for improved binding affinity could further be mutated to adopt a pH switchable interaction. The redesigned interface of Protein G-IgG Fc domain, when incorporated with histidine and glutamic acid on Protein G (PrG-EHHE), showed a switch in binding affinity by 50-fold when pH was altered from mild acidic to mild basic. The wild type (WT) interface only showed negligible switch. The overall binding affinity at mild acidic pH for PrG-EHHE outperformed the WT PrG interaction. The new reagent PrG-EHHE will be revolutionary in IgG purification since the traditional method of using an extreme acidic pH for elution can be circumvented.Abstract Figure


2004 ◽  
Vol 283 ◽  
pp. 161-177 ◽  
Author(s):  
S Andréfouët ◽  
C Payri ◽  
EJ Hochberg ◽  
C Hu ◽  
MJ Atkinson ◽  
...  

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