Neurosurgical Revascularization for Cerebral Ischemic Disease

2015 ◽  
pp. 2823-2833 ◽  
Author(s):  
Daniel Hänggi ◽  
Nima Etminan
2010 ◽  
Vol 90 (4) ◽  
pp. 1230-1235 ◽  
Author(s):  
Ping Wang ◽  
Michael A. Acker ◽  
Michel Bilello ◽  
Elias R. Melhem ◽  
Elizabeth Stambrook ◽  
...  

Author(s):  
Atif Ahmed ◽  
Kuldeep Poorani ◽  
Mohammad Amjad Kalhoro ◽  
Nisar Ahmed Khokar ◽  
Abdul Ghaffar Dars

Aim: To study the incidence of HbA1c elevation in patients with ischemic stroke whose blood glucose levels were normal within the last six months. Study Design: A cross-sectional study. Place and Duration: This cross-sectional study of the 96 patients with cerebral ischemic disease selected from the internal medicine department of Bilawal medical college Hospital Kotri, Sindh, Pakistan for one-year duration from August 2019 to August 2020. Methods: Crossectional study was conducted in the internal medicinal department of Bilawal Medical college Hospital, Kotri Sindh, Pakistan for the period of one year from August 2019 to August 2020. Total 96 study subjects were selected with cerebral ischemic disease, 62 were males and 34 were females. Many factors such as age more than 20 years, ischemic stroke and RBG (Random Blood Glucose) were also evaluated from each participant. SPSS 23.00 version was used for statistical analysis of research data. Results: 57.01 ± 13.4 years was the mean age of the patients. 62 (64.6%) patients were male and 34 (35.4%) were female. The male to female ratio was 2:1. HbA1c was elevated in 35 (36.5%) of 96 patients, while 61 (63.5%) had normal HbA1c.  The distribution of HbA1c elevation by gender showed that 20 (57.1%) patients with elevated HbA1c were men and 15 (42.9%) were women. Forty-three (70.5%) of 61 patients with normal HbA1c were male and 18 (29.5%) were female. Conclusion: it was concluded that glycated haemoglobin plays an important role for reducing the macro complication of Diabetes and the major macro complication observed was cerebral ischemic stroke among the people with elevated HbA1c.


1997 ◽  
Vol 4 (4) ◽  
pp. 457-462
Author(s):  
Hirofumi Oyama ◽  
Masahiro Niwa ◽  
Yoshihisa Kida ◽  
Takayuki Tanaka ◽  
Takanori Iwakoshi ◽  
...  

Stroke ◽  
2019 ◽  
Vol 50 (8) ◽  
pp. 2072-2079 ◽  
Author(s):  
Salama Chaker ◽  
Khalid Al-Dasuqi ◽  
Hediyeh Baradaran ◽  
Michelle Demetres ◽  
Diana Delgado ◽  
...  

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Yang Xu ◽  
Ji Zhang ◽  
Lingsong Ma ◽  
Shoucai Zhao ◽  
Shizun Li ◽  
...  

Necroptosis is the best-described form of regulated necrosis at present, which is widely recognized as a component of caspase-independent cell death mediated by the concerted action of receptor-interacting protein kinase 1 (RIPK1) and receptor-interacting protein kinase 3 (RIPK3). Mixed-lineage kinase domain-like (MLKL) was phosphorylated by RIPK3 at the threonine 357 and serine 358 residues and then formed tetramers and translocated onto the plasma membrane, which destabilizes plasma membrane integrity leading to cell swelling and membrane rupture. Necroptosis is downstream of the tumor necrosis factor (TNF) receptor family, and also interaction with NOD-like receptor pyrin 3 (NLRP3) induced inflammasome activation. Multiple inhibitors of RIPK1 and MLKL have been developed to block the cascade of signal pathways for procedural necrosis and represent potential leads for drug development. In this review, we highlight recent progress in the study of roles for necroptosis in cerebral ischemic disease and discuss how these modifications delicately control necroptosis.


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