Developmental Defects in El Mouse Neurons and Their Normalization by a New Antiepileptic Drug, TJ-960

1991 ◽  
pp. 259-262
Author(s):  
E. Sugaya ◽  
A. Sugaya ◽  
K. Kajiwara ◽  
T. Tsuda ◽  
H. Takagi ◽  
...  
Keyword(s):  
Antiepileptic Drug ◽  
El Mouse ◽  
Developmental Defects

scholarly journals Preliminary Results Regarding Sleep in a Zebrafish Model of Autism Spectrum Disorder

2021 ◽  
Vol 11 (5) ◽  
pp. 556
Author(s):  
Madalina Andreea Robea ◽  
Alin Ciobica ◽  
Alexandrina-Stefania Curpan ◽  
Gabriel Plavan ◽  
Stefan Strungaru ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Valproic Acid ◽  
Social Behavior ◽  
Antiepileptic Drug ◽  
Alternative Model ◽  
Neurological Diseases ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Zebrafish Model ◽  
Developmental Defects

Autism spectrum disorder (ASD) is one of the most salient developmental neurological diseases and remarkable similarities have been found between humans and model animals of ASD. A common method of inducing ASD in zebrafish is by administrating valproic acid (VPA), which is an antiepileptic drug that is strongly linked with developmental defects in children. In the present study we replicated and extended the findings of VPA on social behavior in zebrafish by adding several sleep observations. Juvenile zebrafish manifested hyperactivity and an increase in ASD-like social behaviors but, interestingly, only exhibited minimal alterations in sleep. Our study confirmed that VPA can generate specific ASD symptoms, indicating that the zebrafish is an alternative model in this field of research.

Factors associated with relapse after antiepileptic drug withdrawal in a selected population with partial epilepsy

1999 ◽  
Vol 41 (9) ◽  
pp. 643-645 ◽  
Author(s):  
Alberto Verrotti ◽  
Simonetta Morresi ◽  
Rocco Cutarella ◽  
Guido Morgese ◽  
Francesco Chiarelli
Keyword(s):  
Antiepileptic Drug ◽  
Drug Withdrawal ◽  
Partial Epilepsy ◽  
Factors Associated ◽  
Antiepileptic Drug Withdrawal

Comparison of CE and HPLC for therapeutic drug monitoring of the antiepileptic drug topiramate

2011 ◽  
Vol 44 (06) ◽  
Author(s):  
R Mandrioli ◽  
L Mercolini ◽  
N Ghedini ◽  
M Amore ◽  
E Kenndler ◽  
...  
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Antiepileptic Drug ◽  
Drug Monitoring ◽  
Therapeutic Drug

Felbamate: Clinical and Molecular Aspects of a Unique Antiepileptic Drug

1998 ◽  
Vol 12 (3) ◽  
pp. 205-222 ◽  
Author(s):  
William M. Brown ◽  
Simon P. Aiken
Keyword(s):  
Antiepileptic Drug ◽  
Molecular Aspects

Clinical Factors influencing Antiepileptic Drug Compliance of Children and Adolescents with Epilepsy

2016 ◽  
Vol 24 (4) ◽  
pp. 211-216 ◽  
Author(s):  
방용현 ◽  
은소희 ◽  
김건하 ◽  
은백린 ◽  
황지현 ◽  
...  
Keyword(s):  
Antiepileptic Drug ◽  
Children And Adolescents ◽  
Clinical Factors ◽  
Drug Compliance ◽  
Factors Influencing

Valproic Acid:

1999 ◽  
Vol 16 (2) ◽  
pp. 130-136 ◽  
Author(s):  
Sayonara Beatriz Ranciaro Fagundes
Keyword(s):  
Health Care ◽  
Valproic Acid ◽  
Antiepileptic Drug ◽  
Detailed Analysis ◽  
Side Effect ◽  
Side Effect Profile ◽  
Care Givers

Clinical pharmacologists, neurologists, and all health care givers must consider the efficacy, safety, and side effect profile of a given antiepileptic drug when determining which drug is best for a given patient.The purpose of this study was to investigate valproic acid with a detailed analysis of the different reports.

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