Critical role of energy supply and glycolysis during short-term hibernation

1996 ◽  
pp. 3-5
Author(s):  
C. S. Apstein ◽  
F. R. Eberli
Keyword(s):  
Energy Supply ◽  
Critical Role ◽  
Short Term

The capacity of short term memory from an evolutionary perspective

2019 ◽  
Author(s):  
Majid Manoochehri
Keyword(s):  
Short Term Memory ◽  
Memory Span ◽  
Critical Role ◽  
Experimental Studies ◽  
Cognitive System ◽  
Evolutionary Approach ◽  
Evolutionary Perspective ◽  
Short Term ◽  
Term Memory

Memory span in humans has been intensely studied for more than a century. In spite of the critical role of memory span in our cognitive system, which intensifies the importance of fundamental determinants of its evolution, few studies have investigated it by taking an evolutionary approach. Overall, we know hardly anything about the evolution of memory components. In the present study, I briefly review the experimental studies of memory span in humans and non-human animals and shortly discuss some of the relevant evolutionary hypotheses.

scholarly journals Explaining semantic short-term memory deficits: Evidence for the critical role of semantic control

2011 ◽  
Vol 49 (3) ◽  
pp. 368-381 ◽  
Author(s):  
Paul Hoffman ◽  
Elizabeth Jefferies ◽  
Matthew A. Lambon Ralph
Keyword(s):  
Short Term Memory ◽  
Critical Role ◽  
Memory Deficits ◽  
Short Term ◽  
Term Memory

Differential Effects of Protein Disulfide Isomerase (PDI) Inhibitors On the Expression of Tissue Factor Procoagulant Activity (TF PCA) by AML Blasts

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 1112-1112
Author(s):  
Cornelia Fischer ◽  
Brigitte Spath ◽  
Ali Amirkhosravi ◽  
Walter Fiedler ◽  
Carsten Bokemeyer ◽  
...  
Keyword(s):  
Critical Role ◽  
Leukemic Cell ◽  
Fold Increase ◽  
Myelogenous Leukemia ◽  
Short Term ◽  
Short Term Treatment ◽  
Hl60 Cells ◽  
Short Term Exposure

Abstract Abstract 1112 Acute myelogenous leukemia (AML) may be complicated by DIC. TF plays a critical role in AML-associated coagulopathy, and induction of apoptosis significantly increases TF PCA on leukemic blasts, mainly via phosphatidylserine (PS) membrane exposure. However, PDI, a thiol isomerase with oxidoreductase and chaperone activity, has also been implicated in cellular TF regulation. Particularly, PDI inhibitors have been shown to exert antithrombotic activity in animal models. Besides its predominant localization in the endoplasmic reticulum, PDI is present on cell surfaces, where it may represent a promising therapeutic target. We investigated the effect of PDI inhibitors on the expression of TF PCA by leukemic HL60 and THP1 cells to explore their potential as anticoagulant drugs for the prevention and/or treatment of AML-associated DIC. Using a fluorescence-based insulin reduction assay, we confirmed inhibition of recombinant human PDI by bacitracin and quercetin-3-rutinoside (also known as rutin and recently shown to be a specific PDI inhibitor) with IC50 values of 0.6 mM and 14 μM, respectively, showing >95% inhibition at 1 mM (bacitracin) and 50 μM (rutin). Significant insulin reductase activity was observed on HL60 cells, and this activity was inhibited by 75% and 49% using 1 mM bacitracin and 100 μM rutin, respectively, suggesting the presence of additional, PDI-independent thiol isomerase activity. Short-term treatment with 100 μM rutin for 15 min also inhibited TF PCA on HL60 cells by 37%. Importantly, the inhibitory effect of rutin on cell-associated PDI and TF activity was completely abolished by cell washing, confirming previous evidence that rutin is a reversible PDI inhibitor. When HL60 cells were exposed to rutin (100 μM) for 24 hrs, cell-associated TF PCA was increased 2.3-fold (P<0.01), an effect that was accompanied by enhanced PS exposure, as assessed by annexin V-FITC binding (positive cells, 32±11 vs. 10±4%; P<0.01), and increased PCA of cellular microparticles (MPs) isolated from culture supernatants, as evidenced by the thrombin generation parameters lag phase (LP, 14±1 vs. 19±4 min), peak thrombin (PT, 55±17 vs. 22±14 nM), and area under the curve (AUC, 1193±329 vs. 476±347 nM*min; P<0.01). Interestingly, treatment with 100 μM rutin also resulted in a 1.7-fold increase in total cellular TF antigen (P=0.07). The effects of long-term incubation with bacitracin (1 mM) were even more pronounced, involving an 8.3-fold and 4.6-fold increase in cell-associated TF PCA and total cellular TF antigen, respectively. PS exposure (45±9%) and shedding of procoagulant MPs (LP, 7±1 min; PT, 175±49 nM; AUC, 2756±402 nM*min) were also significantly increased. While neither short-term nor long-term exposure to rutin affected TF PCA on THP1 cells, co-incubation with rutin dose-dependently (10–100 μM) inhibited daunorubicin-induced TF PCA in this cell model, an effect that could not be explained by decreased PS exposure. Importantly, both the reaction pattern of HL60 and that of THP1 cells were reproduced ex vivo using myeloblasts from AML patients. In summary, our findings suggest a highly complex and context-dependent role of PDI in leukemic-cell TF PCA expression. While short-term exposure to rutin can reversibly inhibit both PDI and TF activity, long-term exposure may result in significantly increased cellular TF PCA and MP shedding, pointing to a possible role of PDI in PS homeostasis, cytoskeleton rearrangement, and/or TF recycling. In addition, induction of leukemic-cell apoptosis and necrosis by cytotoxic drugs, which is associated with an early loss in membrane integrity and enhanced accessibility of cytoplasmic enzymes, may involve an additional role of (intracellular) PDI in the efficient presentation of TF PCA by AML blasts. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Critical role of toxicologic pathology in a short-term screen for carcinogenicity

2016 ◽  
Vol 29 (4) ◽  
pp. 215-227 ◽  
Author(s):  
Samuel M. Cohen ◽  
Lora L. Arnold
Keyword(s):  
Critical Role ◽  
Short Term

scholarly journals Does evolution design robust food webs?

2020 ◽  
Vol 287 (1930) ◽  
pp. 20200747
Author(s):  
B. Girardot ◽  
M. Gauduchon ◽  
F. Ménard ◽  
J. C. Poggiale
Keyword(s):  
Food Webs ◽  
Energy Supply ◽  
Ecological Communities ◽  
Short Term ◽  
Trophic Networks ◽  
Crucial Effect ◽  
Community Evolution ◽  
History Of ◽  
Past Conditions

Theoretical works that use a dynamical approach to study the ability of ecological communities to resist perturbations are largely based on randomly generated ecosystem structures. By contrast, we ask here whether the evolutionary history of food webs matters for their robustness. Using a community evolution model, we first generate trophic networks by varying the level of energy supply (richness) of the environment in which species adapt and diversify. After placing our simulation outputs in perspective with present-day food webs empirical data, we highlight the complex, structuring role of this environmental condition during the evolutionary setting up of trophic networks. We then assess the robustness of food webs by studying their short-term ecological responses to swift changes in their customary environmental richness. We reveal that the past conditions have a crucial effect on the robustness of current food webs. Moreover, directly focusing on connectance of evolved food webs, it turns out that the most connected ones appear to be the least robust to sharp depletion in the environmental energy supply. Finally, we appraise the ‘adaptation’ of food webs themselves: generally poor, except in relation to a diversity of flux property.

scholarly journals Multi-target attention and visual short-term memory capacity are closely linked in the intraparietal sulcus

2018 ◽  
Author(s):  
Maren Prass ◽  
Bianca de Haan
Keyword(s):  
Short Term Memory ◽  
Critical Role ◽  
Memory Capacity ◽  
Intraparietal Sulcus ◽  
Short Term ◽  
Term Memory ◽  
Visual Short Term Memory ◽  
General Capacity ◽  
The Right

The existing literature suggests a critical role for both the right intraparietal sulcus (IPS) and the right temporo-parietal junction (TPJ) in our ability to attend to multiple simultaneously-presented lateralised targets (multi-target attention), and the failure of this ability in extinction patients. Currently, however, the precise role of each of these areas in multi-target attention is unclear. In this study, we combined the theory of visual attention (TVA) with functional magnetic resonance imaging (fMRI) guided continuous theta burst stimulation (cTBS) in neurologically healthy subjects to directly investigate the role of the right IPS and TPJ in multi-target attention. Our results show that cTBS at an area of the right IPS associated with multi-target attention elicits a reduction of visual short-term memory capacity. This suggests that the right IPS is associated with a general capacity-limited encoding mechanism that is engaged regardless of whether targets have to be attended or remembered. Curiously, however, cTBS to the right IPS failed to elicit extinction-like behaviour in our study, supporting previous suggestions that different areas of the right IPS may provide different contributions to multi-target attention. CTBS to the right TPJ failed to induce a change in either TVA parameters or extinction-like behaviour.

scholarly journals Impact of Exposure to Environmental Enrichment on the Anxiety-Like Behavior of Ovariectomized Mice

2020 ◽  
Author(s):  
Alfredo Briones-Aranda ◽  
Manuela Castellanos-Pérez ◽  
Victor Manuel Vega-Villa ◽  
Ofir Picazo
Keyword(s):  
Environmental Enrichment ◽  
Critical Role ◽  
Anxiolytic Effect ◽  
Intact Female ◽  
Short Term ◽  
Intact Male ◽  
Ovariectomized Mice ◽  
Plus Maze ◽  
Nih Swiss

Objective: The aim of this study was to explore the influence of short-term (2-week) exposure to social (SE) and/or physical enrichment (PE) on the anxiety-like behavior of ovariectomized (OVX) NIH Swiss mice. Method: One week after surgery, each OVX mouse was housed under one of 4 social conditions: (1) isolated, (2) accompanied by an intact female, (3) accompanied by an intact male, or (4) in a community of 10 OVX individuals. The animals in each of these environments were divided into 2 subgroups, consisting of the presence and absence of PE. Following a 2-week exposure to the respective conditions, each OVX mouse was subjected to either the light/dark exploration test (LDT) or the elevated plus maze (EPM) to examine anxiety-like behavior. Results: The LDT and EPM showed very similar patterns. Compared to an impoverished environment, PE elicited a significant anxiolytic effect for OVX mice housed alone or in companion of an intact female (F [1, 54] = 16.11, P = 0.001). By contrast, mice living in community but without PE displayed anxiogenic-like behavior, perhaps due to crowding, compared to the animals living in isolation (F [1, 36] = 5.64, P = 0.023). Conclusion: This study emphasized the importance of taking housing conditions into account during the screening of new anxiolytic agents and the critical role of OVX in the regulation of anxiety.

The Role of the SLP in Autism Spectrum Disorder Screening and Assessment

2008 ◽  
Vol 15 (2) ◽  
pp. 50-59 ◽  
Author(s):  
Amy Philofsky
Keyword(s):  
Language Development ◽  
Critical Role ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Children With Asd ◽  
Prevalence Estimates ◽  
Notable Increase ◽  
Screening Assessment ◽  
Critical Components

AbstractRecent prevalence estimates for autism have been alarming as a function of the notable increase. Speech-language pathologists play a critical role in screening, assessment and intervention for children with autism. This article reviews signs that may be indicative of autism at different stages of language development, and discusses the importance of several psychometric properties—sensitivity and specificity—in utilizing screening measures for children with autism. Critical components of assessment for children with autism are reviewed. This article concludes with examples of intervention targets for children with ASD at various levels of language development.

A critical role of iNOS-derived Nitric Oxide (NO) and progesterone in implantation

1998 ◽  
Vol 5 (1) ◽  
pp. 115A-115A
Author(s):  
K CHWALISZ ◽  
E WINTERHAGER ◽  
T THIENEL ◽  
R GARFIELD
Keyword(s):  
Nitric Oxide ◽  
Critical Role
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