Protective Efficacy of Marek’s Disease Vaccines

2001 ◽  
pp. 57-90 ◽  
Author(s):  
R. L. Witter
Keyword(s):  
Protective Efficacy ◽  
Marek's Disease ◽  
Marek’S Disease

Host genetic resistance to Marek's disease sustains protective efficacy of herpesvirus of turkey in both experimental and commercial lines of chickens

Vaccine ◽  
2014 ◽  
Vol 32 (16) ◽  
pp. 1820-1827 ◽  
Author(s):  
Shuang Chang ◽  
Qingmei Xie ◽  
John R. Dunn ◽  
Catherine W. Ernst ◽  
Jiuzhou Song ◽  
...  
Keyword(s):  
Protective Efficacy ◽  
Genetic Resistance ◽  
Marek's Disease ◽  
Marek’S Disease ◽  
Host Genetic

scholarly journals Vaccination and Host Marek's Disease-Resistance Genotype Significantly Reduce Oncogenic Gallid alphaherpesvirus 2 Telomere Integration in Host Birds

2018 ◽  
Vol 156 (4) ◽  
pp. 204-214 ◽  
Author(s):  
Marla C. McPherson ◽  
Hans H. Cheng ◽  
Justin M. Smith ◽  
Mary E. Delany
Keyword(s):  
Temporal Dynamics ◽  
Protective Efficacy ◽  
Marek's Disease ◽  
Host Genome ◽  
Marek’S Disease ◽  
Susceptible Genotype ◽  
Host Genotype ◽  
Host Genetics ◽  
Genome Interactions ◽  
Virus Integration

Marek's disease (MD) is an infectious disease characterized by lymphomas and high mortality in susceptible chickens. The causative and ubiquitous alpha-herpesvirus known as MD virus (MDV) integrates into host telomeres during early infection through latency, known to be an important phase for oncogenic transformation. Herein, we sought to determine the influence of vaccination and host genetics on the temporal dynamics of MDV-host genome interactions. We studied integration profiles using 2 MD vaccines that vary in protective efficacy in 2 genetic lines that differ in MD resistance/susceptibility. Virus integration of both oncogenic MDV and vaccine strains was observed in both MD susceptible and resistant birds, however, the lines differed in their dynamic telomere-integration profiles. Notably, the resistant host genotype exhibited a smaller percentage of replicating cells with the virus telomere-integrated only phenotype as compared to the susceptible genotype. Vaccination with Rispens, the most protective MD vaccine, also reduced the establishment of the virus telomere-integrated only phenotype, suggesting a significant role of the phenotype in MD lymphoma development. The effect of Rispens vaccination was most dramatic in the susceptible genotype. These results suggest important connections between vaccinal immunity, MDV telomere integration, virus-induced oncogenesis, and virus-host genome interactions in the context of host genetics and disease susceptibility.

scholarly journals Deletion of the BAC sequences from recombinant meq-null Marek's disease (MD) virus increases immunosuppression while maintaining protective efficacy against MD

2016 ◽  
Vol 95 (7) ◽  
pp. 1504-1512 ◽  
Author(s):  
S. Su ◽  
N. Cui ◽  
J. Li ◽  
P. Sun ◽  
H. Li ◽  
...  
Keyword(s):  
Protective Efficacy ◽  
Marek's Disease ◽  
Marek’S Disease

Protective Efficacy of Marek's Disease Virus (MDV) CVI-988 CEF 65 Clone C against Challenge Infection with Three Very Virulent MDV Strains

1986 ◽  
Vol 30 (2) ◽  
pp. 276 ◽  
Author(s):  
G. F. de Boer ◽  
J. E. Groenendal ◽  
H. M. Boerrigter ◽  
G. L. Kok ◽  
J. M. A. Pol
Keyword(s):  
Disease Virus ◽  
Protective Efficacy ◽  
Marek's Disease Virus ◽  
Challenge Infection ◽  
Marek's Disease ◽  
Marek’S Disease Virus ◽  
Marek’S Disease

Electron Microscopy of a Herpesvirus Isolated from Marek's Disease in Duck and Chicken Embryo Fibroblast Cultures

1968 ◽  
Vol 26 ◽  
pp. 222-223 ◽  
Author(s):  
Keyvan Nazerian
Keyword(s):  
Inclusion Bodies ◽  
Chicken Embryo Fibroblast ◽  
Marek's Disease ◽  
Marek’S Disease ◽  
Duck Embryo Fibroblast ◽  
Multinucleated Cells ◽  
Viral Particles ◽  
Infected Cells ◽  
And Control ◽  
Do So

A herpes-like virus has been isolated from duck embryo fibroblast (DEF) cultures inoculated with blood from Marek's disease (MD) infected birds. Cultures which contained this virus produced MD in susceptible chickens while virus negative cultures and control cultures failed to do so. This and other circumstantial evidence including similarities in properties of the virus and the MD agent implicate this virus in the etiology of MD.Histochemical studies demonstrated the presence of DNA-staining intranuclear inclusion bodies in polykarocytes in infected cultures. Distinct nucleo-plasmic aggregates were also seen in sections of similar multinucleated cells examined with the electron microscope. These aggregates are probably the same as the inclusion bodies seen with the light microscope. Naked viral particles were observed in the nucleus of infected cells within or on the edges of the nucleoplasmic aggregates. These particles measured 95-100mμ, in diameter and rarely escaped into the cytoplasm or nuclear vesicles by budding through the nuclear membrane (Fig. 1). The enveloped particles (Fig. 2) formed in this manner measured 150-170mμ in diameter and always had a densely stained nucleoid. The virus in supernatant fluids consisted of naked capsids with 162 hollow, cylindrical capsomeres (Fig. 3). Enveloped particles were not seen in such preparations.

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