Host genetic resistance to Marek's disease sustains protective efficacy of herpesvirus of turkey in both experimental and commercial lines of chickens

Vaccine ◽  
2014 ◽  
Vol 32 (16) ◽  
pp. 1820-1827 ◽  
Author(s):  
Shuang Chang ◽  
Qingmei Xie ◽  
John R. Dunn ◽  
Catherine W. Ernst ◽  
Jiuzhou Song ◽  
...  
Keyword(s):  
Protective Efficacy ◽  
Genetic Resistance ◽  
Marek's Disease ◽  
Marek’S Disease ◽  
Host Genetic

Quantitative analysis of Marek's disease vaccine virus in relation to host genetic resistance

1998 ◽  
Vol 27 (sup1) ◽  
pp. S89-S89 ◽  
Author(s):  
S. M. Sellers ◽  
T. F. Davison ◽  
N. Bumstead
Keyword(s):  
Quantitative Analysis ◽  
Genetic Resistance ◽  
Vaccine Virus ◽  
Marek's Disease ◽  
Marek’S Disease ◽  
Host Genetic

Genetic resistance to two Marek's disease viruses and its relationship to production traits in chickens

1992 ◽  
Vol 72 (2) ◽  
pp. 213-225 ◽  
Author(s):  
H. Ameli ◽  
J. S. Gavora ◽  
R. W. Fairfull ◽  
J. L. Spencer
Keyword(s):  
Egg Production ◽  
Genetic Correlations ◽  
Genetic Resistance ◽  
Total Mortality ◽  
Marek's Disease ◽  
Production Test ◽  
Production Traits ◽  
Marek’S Disease ◽  
Genetic Groups ◽  
Challenge Tests

Genetic variability of resistance to Marek's Disease (MD), and relationships between MD incidence and egg production traits were studied in 23 genetic groups of experimental and commercial meat and egg chickens. In the challenge tests, chickens were injected with either moderately virulent BC-1 MD virus (BC-1) or highly virulent RB-1B MD virus (RB-1B). In the 497-d egg-production test, sisters of challenged birds were vaccinated for MD on the day of hatch and there were no outbreaks of MD. Heritabilities for MD incidence, MD mortality, and total mortality in the challenge tests, based on data from three unselected control strains of Leghorns were generally low (0.06, 0.13 and 0.20) with BC-1. With RB-1B, the heritability estimates were significantly (P <.05) higher (0.62, 1.00 and 0.96). Intraclass correlations, based on variation between and within the genetic groups were also higher with RB-1B. In the test with BC-1 there were deaths from an early mortality syndrome (EMS) prior to development of MD. Losses from EMS in Leghorns were highest in 2 genetic groups most resistant to MD. Based on genetic group means, correlations between MD incidence and egg production and egg weight were high and negative. In contrast the correlations between MD incidence, age at first egg, total blood spots, and egg specific gravity tended to be positive. No consistent relationships were found with adult body weight. Key words: Marek's disease, genetic resistance, heritability, genetic correlations, production traits, chickens

Validation of Alternative Transcript Splicing in Chicken Lines that Differ in Genetic Resistance to Marek’s Disease

2016 ◽  
Vol 27 (4) ◽  
pp. 238-244 ◽  
Author(s):  
Muhammet Kaya ◽  
Likit Preeyanon ◽  
Jerry B. Dodgson ◽  
Hans H. Cheng
Keyword(s):  
Genetic Resistance ◽  
Marek's Disease ◽  
Alternative Transcript ◽  
Marek’S Disease

scholarly journals Vaccination and Host Marek's Disease-Resistance Genotype Significantly Reduce Oncogenic Gallid alphaherpesvirus 2 Telomere Integration in Host Birds

2018 ◽  
Vol 156 (4) ◽  
pp. 204-214 ◽  
Author(s):  
Marla C. McPherson ◽  
Hans H. Cheng ◽  
Justin M. Smith ◽  
Mary E. Delany
Keyword(s):  
Temporal Dynamics ◽  
Protective Efficacy ◽  
Marek's Disease ◽  
Host Genome ◽  
Marek’S Disease ◽  
Susceptible Genotype ◽  
Host Genotype ◽  
Host Genetics ◽  
Genome Interactions ◽  
Virus Integration

Marek's disease (MD) is an infectious disease characterized by lymphomas and high mortality in susceptible chickens. The causative and ubiquitous alpha-herpesvirus known as MD virus (MDV) integrates into host telomeres during early infection through latency, known to be an important phase for oncogenic transformation. Herein, we sought to determine the influence of vaccination and host genetics on the temporal dynamics of MDV-host genome interactions. We studied integration profiles using 2 MD vaccines that vary in protective efficacy in 2 genetic lines that differ in MD resistance/susceptibility. Virus integration of both oncogenic MDV and vaccine strains was observed in both MD susceptible and resistant birds, however, the lines differed in their dynamic telomere-integration profiles. Notably, the resistant host genotype exhibited a smaller percentage of replicating cells with the virus telomere-integrated only phenotype as compared to the susceptible genotype. Vaccination with Rispens, the most protective MD vaccine, also reduced the establishment of the virus telomere-integrated only phenotype, suggesting a significant role of the phenotype in MD lymphoma development. The effect of Rispens vaccination was most dramatic in the susceptible genotype. These results suggest important connections between vaccinal immunity, MDV telomere integration, virus-induced oncogenesis, and virus-host genome interactions in the context of host genetics and disease susceptibility.

Sign in / Sign up

Export Citation Format

Share Document