Functional Dissection of the Diseased Liver

1983 ◽  
pp. 29-44 ◽  
Author(s):  
R. Preisig
Keyword(s):  
Diseased Liver

Difference of Regeneration Potential Between Healthy and Diseased Liver

2012 ◽  
Vol 44 (2) ◽  
pp. 338-340 ◽  
Author(s):  
M.K. Ju ◽  
G.H. Choi ◽  
J.S. Park ◽  
D.S. Yoon ◽  
J. Choi ◽  
...  
Keyword(s):  
Regeneration Potential ◽  
Diseased Liver

Speed of sound in diseased liver observed by scanning acoustic microscopy with 80 MHz and 250 MHz

2016 ◽  
Vol 139 (1) ◽  
pp. 512-519 ◽  
Author(s):  
So Irie ◽  
Kenta Inoue ◽  
Kenji Yoshida ◽  
Jonathan Mamou ◽  
Kazuto Kobayashi ◽  
...  
Keyword(s):  
Speed Of Sound ◽  
Acoustic Microscopy ◽  
Scanning Acoustic Microscopy ◽  
Diseased Liver

Use of Stem Cells to Block the Activation of Hepatic Stellate Cells in Diseased Liver

2014 ◽  
pp. 221-232 ◽  
Author(s):  
Syamantak Majumder ◽  
Palanivel Gajalakshmi ◽  
Suvro Chatterjee
Keyword(s):  
Stem Cells ◽  
Hepatic Stellate Cells ◽  
Stellate Cells ◽  
Diseased Liver

HEMOSTATIC EVALUATION OF PATIENTS UNDERGOING LIVER TRANSPLANTATION

1987 ◽  
Author(s):  
S R Rettke ◽  
C A Owen ◽  
E J W Bowie ◽  
T L Cole ◽  
R H Wiesner ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Blood Flow ◽  
Coagulation Factors ◽  
Stage Ii ◽  
Skin Closure ◽  
Donor Liver ◽  
Ischemia Time ◽  
Arterial Blood ◽  
Significant Difference ◽  
Diseased Liver

Significant hemostatic abnormalities can occur during orthotopic liver transplantation (OLT). This study addressed three goals: 1)evaluation of the hemostatic mechanism at each stage of the OLT; 2) the relationship of the coagulation process with the thrombelastograph (TEG); and 3) comparison of results in patients requiring retransplantation or who died, with the overall pattern. To evaluate hemostasis during 50 consecutive OLTs, a detailed coagulation and TEG study was done. The surgical procedure was divided into the following stages: Stage I--induction of anesthesia to occlusion of blood flow to the patient’ s diseased liver; Stage II—occlusion of blood flow to the patient’ s diseased liver to reperfusion of the patient’ s new liver; and Stage III—reperfusion of the new liver until skin closure. 28 ml of arterial blood were sampled at the beginning and end of each stage and up to five days posttransplantation for the following: platelet count, prothrombin time, activated partial thromboplastin time, fibrinogen, prothrombin, factors V, VII, IX, and X, plasminogen, antiplasmin, antithrombin III (functional and immunologic), fibrinolytic split products, and TEG. The patient’ s core temperature and amount of blood products transfused were obtained intraoperatively during each of the six data times. The ischemia time of the donor liver was recorded. Significant hemostatic abnormalities developed during each of the 50 OLTs, especially during reperfusion of the donor liver. In some instances, this was corrected within one hour, but platelet counts continued to fall, and a number of coagulation factors rebounded only partially. The TEG values correlated with laboratory data and blood loss, but the correlations were not strong. The patient’ s requirement for red cells varied with the operative drop in temperature; however, the donor liver ischemia time and length of Stage II made no significant difference. It is concluded that 1) significant deterioration of coagulation factors occurs during OLT, 2) the TEG is an effective screening test that affords prompt information, 3) aggressive measures should be taken to maintain the patient’ s body temperature at 37°C, 4) patient outcome was not predicted by intraoperative hemostatic evaluation.

Resolving fibrosis in the diseased liver: Translating the scientific promise to the clinic

2007 ◽  
Vol 39 (4) ◽  
pp. 695-714 ◽  
Author(s):  
Ajay K. Muddu ◽  
Indra Neil Guha ◽  
Ahmed M. Elsharkawy ◽  
Derek A. Mann
Keyword(s):  
Diseased Liver

Impact of diseased liver parenchyma on perioperative outcome among patients with hepatocellular carcinoma undergoing hepatectomy: Experience from a developing country

2020 ◽  
Vol 35 ◽  
pp. 236-242
Author(s):  
Aleksandar Bogdanovic ◽  
Predrag Bulajic ◽  
Marinko Zuvela ◽  
Nemanja Bidzic ◽  
Marko Zivanovic ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Developing Country ◽  
Liver Parenchyma ◽  
Perioperative Outcome ◽  
Diseased Liver

scholarly journals Antifibrotic Effects of Amyloid-Beta and Its Loss in Cirrhotic Liver

Cells ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 452 ◽  
Author(s):  
Gayane Hrachia Buniatian ◽  
Ralf Weiskirchen ◽  
Thomas S. Weiss ◽  
Ute Schwinghammer ◽  
Martin Fritz ◽  
...  
Keyword(s):  
Amyloid Beta ◽  
Potential Role ◽  
Transforming Growth Factor ◽  
Smooth Muscle Actin ◽  
Transforming Growth Factor Β ◽  
Cirrhotic Liver ◽  
Liver Sinusoidal Endothelial Cells ◽  
Beta Secretase ◽  
Diseased Liver

The function and regulation of amyloid-beta (Aβ) in healthy and diseased liver remains unexplored. Because Aβ reduces the integrity of the blood-brain barrier we have examined its potential role in regulating the sinusoidal permeability of normal and cirrhotic liver. Aβ and key proteins that generate (beta-secretase 1 and presenilin-1) and degrade it (neprilysin and myelin basic protein) were decreased in human cirrhotic liver. In culture, activated hepatic stellate cells (HSC) internalized Aβ more efficiently than astrocytes and HSC degraded Aβ leading to suppressed expression of α-smooth muscle actin (α-SMA), collagen 1 and transforming growth factor β (TGFβ). Aβ also upregulated sinusoidal permeability marker endothelial NO synthase (eNOS) and decreased TGFβ in cultured human liver sinusoidal endothelial cells (hLSEC). Liver Aβ levels also correlate with the expression of eNOS in transgenic Alzheimer’s disease mice and in human and rodent cirrhosis/fibrosis. These findings suggest a previously unexplored role of Aβ in the maintenance of liver sinusoidal permeability and in protection against cirrhosis/fibrosis via attenuation of HSC activation.

Proliferating Cholangiocytes: A Neuroendocrine Compartment in the Diseased Liver

2007 ◽  
Vol 132 (1) ◽  
pp. 415-431 ◽  
Author(s):  
Domenico Alvaro ◽  
Maria Grazia Mancino ◽  
Shannon Glaser ◽  
Eugenio Gaudio ◽  
Marco Marzioni ◽  
...  
Keyword(s):  
Diseased Liver

Frequency‐dependent ultrasonic differentiation of normal and diffusely diseased liver

1987 ◽  
Vol 82 (4) ◽  
pp. 1131-1138 ◽  
Author(s):  
T. Lin ◽  
J. Ophir ◽  
G. Potter
Keyword(s):  
Frequency Dependent ◽  
Diseased Liver
Sign in / Sign up

Export Citation Format

Share Document