PET Studies of Local Brain Metabolism During Sensory and Motor Tasks: Strategies, Results and Applications in Neurologic and Psychiatric Diseases

EFFECTS OF SUBARACHNOID BLOCK ON LOCAL BRAIN METABOLISM DURING UNILATERAL SCIATIC STIMULATION

Anesthesiology ◽

10.1097/00000542-198609001-00208 ◽

1986 ◽

Vol 65 (Supplement 3A) ◽

pp. A209

Author(s):

D M Lin ◽

H M Shapiro ◽

D. J Cole

Keyword(s):

Brain Metabolism ◽

Subarachnoid Block ◽

Local Brain

Download Full-text

Does technetium-99m bicisate image local brain metabolism in late ictal temporal lobe epilepsy?

European Journal of Nuclear Medicine ◽

10.1007/bf00182362 ◽

1994 ◽

Vol 21 (11) ◽

Cited By ~ 5

Author(s):

JyrkiT. Kuikka ◽

Esa Mervaala ◽

Esko Vanninen ◽

Reetta K�lvi�inen

Keyword(s):

Temporal Lobe Epilepsy ◽

Temporal Lobe ◽

Brain Metabolism ◽

Technetium 99M ◽

Local Brain

Download Full-text

Deletion of Crtc1 leads to hippocampal neuroenergetic impairments associated with depressive-like behavior

10.1101/2020.11.05.370221 ◽

2020 ◽

Author(s):

Antoine Cherix ◽

Carole Poitry-Yamate ◽

Bernard Lanz ◽

Olivia Zanoletti ◽

Jocelyn Grosse ◽

...

Keyword(s):

Metabolic Syndrome ◽

Mood Disorders ◽

Metabolic Disorders ◽

Brain Metabolism ◽

Imaging Biomarkers ◽

Psychiatric Diseases ◽

Preclinical Models ◽

Potential Therapeutic Target ◽

Clinical Potential ◽

Insight Into

AbstractMood disorders (MD) are a major burden on society as their biology remains poorly understood, challenging both diagnosis and therapy. Among many observed biological dysfunctions, homeostatic dysregulation, such as metabolic syndrome (MeS), shows considerable comorbidity with MD. Recently, CREB-regulated transcription coactivator 1 (CRTC1), a regulator of brain metabolism, was proposed as a promising factor to understand this relationship. Searching for imaging biomarkers and associating them with pathophysiological mechanisms using preclinical models, can provide significant insight into these complex psychiatric diseases and help the development of personalized healthcare. Here, we used neuroimaging technologies to show that deletion of Crtc1 in mice leads to an imaging fingerprint of hippocampal metabolic impairment related to depressive-like behavior. By identifying the underlying molecular/physiological origin, we could assign an energy-boosting mood-stabilizing treatment, ebselen, which rescued behavior and neuroimaging markers. Finally, our results point towards the GABAergic system as a potential therapeutic target for behavioral dysfunctions related to metabolic disorders. This study provides new insights on Crtc1’s and MeS’s relationship to MD and establishes depression-related markers with clinical potential.

Download Full-text