Neural Network Formation and the Activity of an Aggregate of Dissociated Hydra Cells

1989 ◽  
pp. 262-263 ◽  
Author(s):  
T. Itayama ◽  
Y. Sawada
Keyword(s):  
Neural Network ◽  
Network Formation

scholarly journals Cytoskeleton and Membrane Organization at Axon Branches

2021 ◽  
Vol 9 ◽  
Author(s):  
Satish Bodakuntla ◽  
Hana Nedozralova ◽  
Nirakar Basnet ◽  
Naoko Mizuno
Keyword(s):  
Neural Network ◽  
Energy Production ◽  
Network Formation ◽  
Local System ◽  
Membrane Remodeling ◽  
Axon Branching ◽  
Cellular Functions ◽  
Branch Formation ◽  
High Degree ◽  
Critical Process

Axon branching is a critical process ensuring a high degree of interconnectivity for neural network formation. As branching occurs at sites distant from the soma, it is necessary that axons have a local system to dynamically control and regulate axonal growth. This machinery depends on the orchestration of cellular functions such as cytoskeleton, subcellular transport, energy production, protein- and membrane synthesis that are adapted for branch formation. Compared to the axon shaft, branching sites show a distinct and dynamic arrangement of cytoskeleton components, endoplasmic reticulum and mitochondria. This review discusses the regulation of axon branching in the context of cytoskeleton and membrane remodeling.

Neural network formation in an aggregate of dissociate hydra cells

1988 ◽  
Vol 1 ◽  
pp. 260 ◽  
Author(s):  
T. Itayama ◽  
O. Koizumi ◽  
Y. Sawada
Keyword(s):  
Neural Network ◽  
Network Formation

Accelerated neural network formation in rat cerebral cortex cultures chronically disinhibited with picrotoxin

1987 ◽  
Vol 97 (2) ◽  
pp. 280-288 ◽  
Author(s):  
F van Huizen ◽  
H.J Romijn ◽  
A.M.M.C Habets ◽  
P van den Hooff
Keyword(s):  
Neural Network ◽  
Cerebral Cortex ◽  
Network Formation ◽  
Rat Cerebral Cortex

Differentiating stem cells on patterned substrates for neural network formation

2011 ◽  
Vol 88 (8) ◽  
pp. 1707-1710 ◽  
Author(s):  
ChunXiong Luo ◽  
Li Liu ◽  
XiaoFang Ni ◽  
Li Wang ◽  
Shinichiro M. Nomura ◽  
...  
Keyword(s):  
Neural Network ◽  
Stem Cells ◽  
Network Formation ◽  
Patterned Substrates

scholarly journals Identification of neural oscillations and epileptiform changes in human brain organoids

2019 ◽  
Author(s):  
Ranmal A. Samarasinghe ◽  
Osvaldo A. Miranda ◽  
Simon Mitchell ◽  
Isabella Ferando ◽  
Momoko Watanabe ◽  
...  
Keyword(s):  
Neural Network ◽  
Human Brain ◽  
Network Architecture ◽  
Network Formation ◽  
Neurological Diseases ◽  
Extracellular Recording ◽  
Brain Network ◽  
Network Activity ◽  
Intact Brain ◽  
Oscillatory Network

ABSTRACTHuman brain organoids represent a powerful tool for the study of human neurological diseases particularly those that impact brain growth and structure. However, many neurological diseases lack obvious anatomical abnormalities, yet significantly impact neural network functions, raising the question of whether organoids possess sufficient neural network architecture and complexity to model these conditions. Here, we explore the network level functions of brain organoids using calcium sensor imaging and extracellular recording approaches that together reveal the existence of complex oscillatory network behaviors reminiscent of intact brain preparations. We further demonstrate strikingly abnormal epileptiform network activity in organoids derived from a Rett Syndrome patient despite only modest anatomical differences from isogenically matched controls, and rescue with an unconventional neuromodulatory drug Pifithrin-α. Together, these findings provide an essential foundation for the utilization of human brain organoids to study intact and disordered human brain network formation and illustrate their utility in therapeutic discovery.

Homophilic synaptic target recognition mediated by immunoglobulin-like cell adhesion molecule Fasciclin III

Development ◽  
1997 ◽  
Vol 124 (20) ◽  
pp. 4143-4152 ◽  
Author(s):  
H. Kose ◽  
D. Rose ◽  
X. Zhu ◽  
A. Chiba
Keyword(s):  
Neural Network ◽  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Growth Cone ◽  
Cell Adhesion Molecule ◽  
Network Formation ◽  
Target Recognition ◽  
Basic Mechanism ◽  
Growth Cones ◽  
Homophilic Interaction

We demonstrate that the cell adhesion molecule Fasciclin III (FAS3) mediates synaptic target recognition through homophilic interaction. FAS3 is expressed by the RP3 motoneuron and its target muscles during synaptic target recognition. The RP3 growth cone can form synapses on muscles that ectopically express FAS3. This mistargeting is dependent on FAS3 expression in the motoneurons. In addition, when the FAS3-negative aCC and SNa motoneuron growth cones ectopically express FAS3, they gain the ability to recognize FAS3-expressing muscles as alternative targets. We propose that homophilic synaptic target recognition serves as a basic mechanism of neural network formation.

Guidance of vascular and neural network formation

2005 ◽  
Vol 15 (1) ◽  
pp. 108-115 ◽  
Author(s):  
Anne Eichmann ◽  
Ferdinand Le Noble ◽  
Monica Autiero ◽  
Peter Carmeliet
Keyword(s):  
Neural Network ◽  
Network Formation
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