Recombinant Inbred Mouse Strains: Models for Studying the Molecular Genetic Basis of Myeloid Tumorigenesis

1989 ◽  
pp. 45-57 ◽  
Author(s):  
Neal G. Copeland ◽  
Arthur M. Buchberg ◽  
Debra J. Gilbert ◽  
Nancy A. Jenkins
Keyword(s):  
Recombinant Inbred ◽  
Genetic Basis ◽  
Inbred Mouse ◽  
Molecular Genetic ◽  
Mouse Strains ◽  
Inbred Mouse Strains ◽  
Recombinant Inbred Mouse ◽  
Molecular Genetic Basis

scholarly journals AKXD recombinant inbred strains: models for studying the molecular genetic basis of murine lymphomas.

1986 ◽  
Vol 6 (12) ◽  
pp. 4236-4243 ◽  
Author(s):  
M L Mucenski ◽  
B A Taylor ◽  
N A Jenkins ◽  
N G Copeland
Keyword(s):  
T Cell ◽  
B Cell ◽  
Recombinant Inbred ◽  
Genetic Basis ◽  
Inbred Mouse ◽  
Molecular Genetic ◽  
Age At Onset ◽  
Mouse Strains ◽  
B Cell Lymphomas ◽  
Molecular Genetic Basis

We analyzed the lymphoma susceptibility of 13 AKXD recombinant inbred mouse strains derived from AKR/J, a highly lymphomatous strain, and DBA/2J, a weakly lymphomatous strain. Of the 13 strains used, 12 showed a high incidence of lymphoma development. However, the average age at onset of lymphoma varied considerably among the different AKXD strains, suggesting that they have segregated several loci that affect lymphoma susceptibility. A relatively unambiguous classification of lymphomas was made possible by using histopathology in addition to detailed molecular characterization of rearrangements in immunoglobulin heavy and kappa light genes and in T-cell receptor beta-chain genes. Among the 12 highly lymphomatous strains, only 2 were identified that, like the parental AKR/J strain, died primarily of T-cell lymphomas. Three strains died primarily of B-cell lymphomas, and one strain primarily of myeloid lymphomas. Six strains were susceptible to both T-cell and B-cell lymphomas. Thus, these strains have segregated genes that affect both lymphoma susceptibility and lymphoma type and should prove to be useful models for studying the molecular genetic basis of murine lymphomas.

AKXD recombinant inbred strains: models for studying the molecular genetic basis of murine lymphomas

1986 ◽  
Vol 6 (12) ◽  
pp. 4236-4243
Author(s):  
M L Mucenski ◽  
B A Taylor ◽  
N A Jenkins ◽  
N G Copeland
Keyword(s):  
T Cell ◽  
B Cell ◽  
Recombinant Inbred ◽  
Genetic Basis ◽  
Inbred Mouse ◽  
Molecular Genetic ◽  
Age At Onset ◽  
Mouse Strains ◽  
B Cell Lymphomas ◽  
Molecular Genetic Basis

We analyzed the lymphoma susceptibility of 13 AKXD recombinant inbred mouse strains derived from AKR/J, a highly lymphomatous strain, and DBA/2J, a weakly lymphomatous strain. Of the 13 strains used, 12 showed a high incidence of lymphoma development. However, the average age at onset of lymphoma varied considerably among the different AKXD strains, suggesting that they have segregated several loci that affect lymphoma susceptibility. A relatively unambiguous classification of lymphomas was made possible by using histopathology in addition to detailed molecular characterization of rearrangements in immunoglobulin heavy and kappa light genes and in T-cell receptor beta-chain genes. Among the 12 highly lymphomatous strains, only 2 were identified that, like the parental AKR/J strain, died primarily of T-cell lymphomas. Three strains died primarily of B-cell lymphomas, and one strain primarily of myeloid lymphomas. Six strains were susceptible to both T-cell and B-cell lymphomas. Thus, these strains have segregated genes that affect both lymphoma susceptibility and lymphoma type and should prove to be useful models for studying the molecular genetic basis of murine lymphomas.

Type I and type II error rates for quantitative trait loci (QTL) mapping studies using recombinant inbred mouse strains

1996 ◽  
Vol 26 (2) ◽  
pp. 149-160 ◽  
Author(s):  
J. K. Belknap ◽  
S. R. Mitchell ◽  
L. A. O'Toole ◽  
M. L. Helms ◽  
J. C. Crabbe
Keyword(s):  
Quantitative Trait ◽  
Recombinant Inbred ◽  
Inbred Mouse ◽  
Error Rates ◽  
Mouse Strains ◽  
Type I ◽  
Inbred Mouse Strains ◽  
Type Ii ◽  
Type Ii Error ◽  
Recombinant Inbred Mouse

Genetic structure of the LXS panel of recombinant inbred mouse strains: a powerful resource for complex trait analysis

2004 ◽  
Vol 15 (8) ◽  
pp. 637-647 ◽  
Author(s):  
Robert W. Williams ◽  
Beth Bennett ◽  
Lu Lu ◽  
Jing Gu ◽  
John C. DeFries ◽  
...  
Keyword(s):  
Genetic Structure ◽  
Recombinant Inbred ◽  
Inbred Mouse ◽  
Complex Trait ◽  
Mouse Strains ◽  
Inbred Mouse Strains ◽  
Recombinant Inbred Mouse ◽  
Trait Analysis

scholarly journals ATR-FTIR spectroscopy reveals genomic loci regulating the tissue response in high fat diet fed BXD recombinant inbred mouse strains

BMC Genomics ◽  
2013 ◽  
Vol 14 (1) ◽  
pp. 386 ◽  
Author(s):  
Ayca Dogan ◽  
Peter Lasch ◽  
Christina Neuschl ◽  
Marion K Millrose ◽  
Rudi Alberts ◽  
...  
Keyword(s):  
Ftir Spectroscopy ◽  
Recombinant Inbred ◽  
High Fat Diet ◽  
Inbred Mouse ◽  
Tissue Response ◽  
Mouse Strains ◽  
Inbred Mouse Strains ◽  
High Fat ◽  
Recombinant Inbred Mouse
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