Detection of Disruption of Sarcolemmal Membrane by Indium-111 Labeled Antimyosin Antibody Scan

1993 ◽  
pp. 88-96
Author(s):  
T. Yasuda
Keyword(s):  
Sarcolemmal Membrane ◽  
Antimyosin Antibody ◽  
Indium 111

Myocyte cell damage after administration of doxorubicin or mitoxantrone in breast cancer patients assessed by indium 111 antimyosin monoclonal antibody studies.

1993 ◽  
Vol 11 (7) ◽  
pp. 1264-1268 ◽  
Author(s):  
M Estorch ◽  
I Carrió ◽  
D Martínez-Duncker ◽  
L Berná ◽  
G Torres ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Advanced Breast Cancer ◽  
Cell Damage ◽  
Myocardial Cell ◽  
Left Ventricular ◽  
Advanced Breast ◽  
Left Ventricular Ejection ◽  
Antimyosin Antibody ◽  
Indium 111 ◽  
Myocardial Cell Damage

PURPOSE To compare myocyte cell damage induced by doxorubicin or mitoxantrone, we performed left ventricular ejection fraction (LVEF) measurements and indium 111 antimyosin antibody studies in a group of patients with advanced breast cancer who had been treated with these anthracycline derivatives. PATIENTS AND METHODS We studied 35 patients eligible to receive chemotherapy including the anthracyclines: doxorubicin or mitoxantrone (cumulative dose of doxorubicin, 500 mg/m2; or mitoxantrone, 120 mg/m2). LVEF was measured before and after 10 cycles of chemotherapy. Antimyosin uptake in the myocardium was quantified by means of a heart-to-lung ratio (HLR). RESULTS Patients treated with doxorubicin presented with a significant decrease in LVEF after chemotherapy (before, 60.4% +/- 8.92%; after, 49.8% +/- 9.71%; P = .001). Antimyosin uptake was observed in all patients with a HLR of 2.03 +/- 0.25. Seven of eight patients with a HLR greater than 2.03 had a greater than 10% decrease in LVEF. Patients treated with mitoxantrone did not present with a decrease in LVEF after chemotherapy (before, 55.4% +/- 6.25%; after, 55.8% +/- 7.25%; not significant). Antimyosin uptake was observed in 14 of 17 patients with a HLR of 1.77 +/- 0.18 (P < .05). CONCLUSION 111In antimyosin monoclonal antibodies defect myocardial cell damage produced by doxorubicin and mitoxantrone. In patients with advanced breast cancer, cumulative doses of 120 mg/m2 of mitoxantrone produce less myocardial cell damage than cumulative doses of 500 mg/m2 of doxorubicin. 111In antimyosin uptake without decrease in LVEF after treatment with mitoxantrone indicates the presence of myocyte cell damage, but not to the extent necessary to deteriorate function. These results indicate that 111In antimyosin antibody studies are useful in the noninvasive comparative assessment of cardiotoxicity produced by different anthracycline derivatives.

Prognostic significance of indium-111 antimyosin antibody uptake in patients with dilated and hypertrophic cardiomyopathy

1991 ◽  
Vol 32 (1) ◽  
pp. 75-81 ◽  
Author(s):  
Akira Matsumori ◽  
Takehiko Yamada ◽  
Nagara Tamaki ◽  
Yuji Watanabe ◽  
Yoshiharu Yonekura ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Prognostic Significance ◽  
Antimyosin Antibody ◽  
Antibody Uptake ◽  
Indium 111

Lyme myocarditis diagnosed by indium-111-antimyosin antibody scintigraphy

1989 ◽  
Vol 15 (6) ◽  
pp. 330-331 ◽  
Author(s):  
Irene Cas�ns ◽  
Anselmo Villar ◽  
Vicente Almenar ◽  
Antonio Blanes
Keyword(s):  
Antimyosin Antibody ◽  
Indium 111

scholarly journals Indium 111-monoclonal antimyosin antibody imaging in the diagnosis of acute myocarditis.

Circulation ◽  
1987 ◽  
Vol 76 (2) ◽  
pp. 306-311 ◽  
Author(s):  
T Yasuda ◽  
I F Palacios ◽  
G W Dec ◽  
J T Fallon ◽  
H K Gold ◽  
...  
Keyword(s):  
Acute Myocarditis ◽  
Antibody Imaging ◽  
Antimyosin Antibody ◽  
Indium 111

scholarly journals Blood flow-dependent uptake of indium-111 monoclonal antimyosin antibody in canine acute myocardial infarction

1993 ◽  
Vol 21 (1) ◽  
pp. 233-239 ◽  
Author(s):  
Freny Vaghaiwalla Mody ◽  
Denis B. Buxton ◽  
Luis I. Araujo ◽  
Michael E. Fishbein ◽  
Carl E. Selin ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Blood Flow ◽  
Antimyosin Antibody ◽  
Indium 111

scholarly journals Comparison of indium-111 antimyosin antibody and technetium-99m pyrophosphate localization in reperfused and nonreperfused myocardial infarction

1991 ◽  
Vol 17 (2) ◽  
pp. 519-526 ◽  
Author(s):  
Kan Takeda ◽  
Norman D. LaFrance ◽  
Harlan F. Weisman ◽  
Henry N. Wagner ◽  
Lewis C. Becker
Keyword(s):  
Myocardial Infarction ◽  
Technetium 99M ◽  
Antimyosin Antibody ◽  
Indium 111
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