Reactive Site Cleavage, Thermodynamic Control Resynthesis, and Properties of Chemically Derivatized Trypsin-Kallikrein-Inhibitors

1974 ◽  
pp. 362-377 ◽  
Author(s):  
H. Tschesche ◽  
H. Jering ◽  
G. Schorp ◽  
T. Dietl
Keyword(s):  
Reactive Site ◽  
Thermodynamic Control ◽  
Kallikrein Inhibitors

Solvent-assisted osmium staining of butyl acrylate and ethylene-propylene-diene in a styrene acrylonitrile matrix

1993 ◽  
Vol 51 ◽  
pp. 900-901 ◽  
Author(s):  
Gudrun A. Hutchins
Keyword(s):  
Butyl Acrylate ◽  
Room Temperature ◽  
Osmium Tetroxide ◽  
Staining Procedure ◽  
Reactive Site ◽  
Ethylene Propylene ◽  
Minimal Distortion ◽  
Styrene Acrylonitrile ◽  
Engineering Polymers ◽  
Effective Reaction

In order to optimize the toughening effect of elastomers in engineering polymers, it is necessary to characterize the size, morphology and dispersion of the specific elastomer within the polymer matrix. For unsaturated elastomers such as butadiene or isoprene, staining with osmium tetroxide is a well established procedure. The residual carbon-carbon double bond in these materials is the reactive site and forms a 1,2-dilato complex with the OsO4. Incorporation of osmium tetroxide into the elastomer not only produces sufficient contrast for TEM, but also crosslinks the elastomer sufficiently so that ultramicrotomy can be accomplished at room temperature with minimal distortion.Blends containing saturated elastomers such as butyl acrylate (BA) and ethylene propylene diene monomer (EPDM) cannot be stained directly with OsO4 because effective reaction sites such as C=C or -NH2 are not available in sufficient number. If additional reaction sites can be introduced selectively into the elastomer by a chemical reaction or the absorption of a solvent, a modified, two-step osmium staining procedure is possible.

Stereodivergent Alkyne Hydrofluorination Using a Simple Practical Reagent

2020 ◽  
Author(s):  
Rui Guo ◽  
Xiaotian Qi ◽  
Hengye Xiang ◽  
Paul Geaneoates ◽  
Ruihan Wang ◽  
...  
Keyword(s):  
Bond Formation ◽  
Biologically Active ◽  
Dft Studies ◽  
Thermodynamic Control ◽  
Important Goal ◽  
Peptide Bonds ◽  
Metal Free ◽  
Vinyl Cation ◽  
E And Z Isomers ◽  
Vinyl Fluorides

Vinyl fluorides play an important role in drug development as they serve as bioisosteres for peptide bonds and are found in a range of biologically active molecules. The discovery of safe, general and practical procedures to prepare vinyl fluorides remains an important goal and challenge for synthetic chemistry. Here we introduce an inexpensive and easily-handled reagent and report simple, scalable, and metal-free protocols for the regioselective and stereodivergent hydrofluorination of alkynes to access both the E and Z isomers of vinyl fluorides. These conditions were suitable for a diverse collection of alkynes, including several highly-functionalized pharmaceutical derivatives. Mechanistic and DFT studies support C–F bond formation through a vinyl cation intermediate, with the (E)- and (Z)-hydrofluorination products forming under kinetic and thermodynamic control, respectively.<br>

scholarly journals CpG Mutations in the Reactive Site of Human C1¯ Inhibitor

1989 ◽  
Vol 264 (6) ◽  
pp. 3066-3071
Author(s):  
K Skriver ◽  
E Radziejewska ◽  
J A Silbermann ◽  
V H Donaldson ◽  
S C Bock
Keyword(s):  
C1 Inhibitor ◽  
Reactive Site

scholarly journals Reaction of human chymase with reactive site variants of alpha 1-antichymotrypsin. Modulation of inhibitor versus substrate properties.

1993 ◽  
Vol 268 (31) ◽  
pp. 23626-23633 ◽  
Author(s):  
N.M. Schechter ◽  
L.M. Jordan ◽  
A.M. James ◽  
B.S. Cooperman ◽  
Z.M. Wang ◽  
...  
Keyword(s):  
Reactive Site ◽  
Substrate Properties

scholarly journals The temperature-sensitive bond in human alpha 2-macroglobulin is the alkylamine-reactive site.

1980 ◽  
Vol 255 (9) ◽  
pp. 3820-3823
Author(s):  
J.B. Howard ◽  
M. Vermeulen ◽  
R.P. Swenson
Keyword(s):  
Temperature Sensitive ◽  
Reactive Site
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