The Role of Growth Factors and Extracellular Matrix Proteases in Active Cell Death in the Prostate

1995 ◽  
pp. 225-246 ◽  
Author(s):  
M. Tenniswood ◽  
R. S. Guenette ◽  
D. Taillefer ◽  
M. Mooibroek
Keyword(s):  
Extracellular Matrix ◽  
Cell Death ◽  
Growth Factors ◽  
Active Cell ◽  
Active Cell Death

Role of active cell death (apoptosis) in multi-stage carcinogenesis

1995 ◽  
Vol 82-83 ◽  
pp. 143-148 ◽  
Author(s):  
R. Schulte-hermann ◽  
W. Bursch ◽  
B. Grasl-kraupp ◽  
L. Török ◽  
A. Ellinger ◽  
...  
Keyword(s):  
Cell Death ◽  
Active Cell ◽  
Multi Stage ◽  
Active Cell Death

scholarly journals Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: the role of autophagy

1996 ◽  
Vol 17 (8) ◽  
pp. 1595-1607 ◽  
Author(s):  
Wilfried Bursch ◽  
Adolf Ellinger ◽  
Harald Kienzl ◽  
Ladislaus Török ◽  
Siyaram Pandey ◽  
...  
Keyword(s):  
Cell Death ◽  
Mammary Carcinoma ◽  
Carcinoma Cells ◽  
Active Cell ◽  
Human Mammary Carcinoma ◽  
Active Cell Death ◽  
Mammary Carcinoma Cells ◽  
Mcf 7

HUMAN MAMMARY AND COLON CARCINOMA CELLS DIE BY DIFFERENT FORMS OF ACTIVE CELL DEATH

1996 ◽  
Vol 24 (4) ◽  
pp. 608S-608S
Author(s):  
K. Hochegger ◽  
B. Marian ◽  
L. Török ◽  
A. Ellinger ◽  
W. Bursch ◽  
...  
Keyword(s):  
Cell Death ◽  
Colon Carcinoma ◽  
Carcinoma Cells ◽  
Active Cell ◽  
Colon Carcinoma Cells ◽  
Active Cell Death

In vitro studies on subtypes and regulation of active cell death

1997 ◽  
Vol 11 (5) ◽  
pp. 579-588 ◽  
Author(s):  
W. Bursch ◽  
A. Ellinger ◽  
L. Török ◽  
W. Parzefall ◽  
S. Coulibaly ◽  
...  
Keyword(s):  
Cell Death ◽  
Active Cell ◽  
In Vitro Studies ◽  
Active Cell Death

Active cell death in ovarian carcinoma cells can be induced with benzamide riboside, an inhibitor of the guanosine pathway

1997 ◽  
Vol 33 ◽  
pp. S35
Author(s):  
Grusch ◽  
G. Fuhrmann ◽  
T. Szekeres ◽  
G. Findenig ◽  
K. Krohn ◽  
...  
Keyword(s):  
Cell Death ◽  
Ovarian Carcinoma ◽  
Carcinoma Cells ◽  
Active Cell ◽  
Ovarian Carcinoma Cells ◽  
Active Cell Death ◽  
Benzamide Riboside

Role of fibrinolysis and α2-macroglobulin in growth of primary adenocarcinoma and rectal polyps.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e15093-e15093
Author(s):  
Evgeniy N. Kolesnikov ◽  
Elena Alekseevna Nikipelova ◽  
Elena Mikhaylovna Frantsiyants ◽  
Larisa Kozlova ◽  
Irina V. Kaplieva ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Growth Factors ◽  
Protective Effect ◽  
Tumor Angiogenesis ◽  
Active Form ◽  
Primary Adenocarcinoma ◽  
Α2 Macroglobulin ◽  
Rectal Polyps ◽  
Resection Line

e15093 Background: An important role in tumor angiogenesis induction is played by hydrolytic systems, in particular plasmin one which provides degradation of the extracellular matrix, activates growth factors and metalloproteinases. Our purpose was to analyze the tissue fibrinolytic system and α2-macroglobulin (α2M) in primary adenocarcinoma (PA) and polyps (P) of the rectum (R). Methods: Tissues of tumors (РА, G2, T2-3N0M0, 42-73 years) and their perifocal zone (PZ) in R (n = 24) and Р (n = 27) were studied by ELISA; the result was calculated per 1 mg of tissue. Results: Resection line (RL) tissues contained levels of tРА antigen and its active form (tРА-Ag and tРА-act) 6.7 and 33.8 times higher than prourokinase and urokinase levels (uPA-Ag and uPA-act). RL tissues in P did not differ significantly from R tissues at PA resection. uPA-act in PA was higher than in RL by 3.2 times, uPA-Ag - 8 times higher, tРА-act - 2.3 times lower; tPA-Ag was similar to RL tissue values. Plasmin-α2-antiplasmin complex (PAP) in PA was 1.4 times higher than in RL. Plasminogen (PG) in PA was 1.5 times lower than in RL (p < 0.01). Activity of α2M in PA and RL did not differ. PAP and α2М in PA PZ were similar to RL, and PG did not differ from PA. Other indices were between tumor and RL levels. P tissue did not show changes in uPA; tPA-act activity was 1.3 times lower than in RL, and tPA-Ag 1.3 times higher (p < 0.01). PAP in tissues of 88.2% P was 1.5 times higher than in RL and 1.7 times lower than in PA. PG and α2М were similar in P and RL. PAP in PZ of P was 2.3 times higher than in RL and 1.5 times higher than in PA PZ. PG in P PZ was 1.4 times lower than in RL (p < 0.01). α2М activity in P PZ was higher than in RL and P by 5.4 times on average. uPA in P PZ did not differ from RL; tРА-Ag and tРА-act were higher than in RL by 1.5 and 1.9 times and exceeded P by 2.1 and 1.5 times (p < 0.01). Prevalence of uPA, activation of PG in PA and its PZ indicated degradation of the extracellular matrix compared with the corresponding P tissues. Conclusions: The role of R tumor PZ as a "metabolic" tumor field in neoplasm progression was confirmed. Activation of fibrinolysis in PA and its PZ with a deficiency of inhibitors stimulates the migration and proliferation of cells. Increasing tРА, РАР and α2М in PZ of polyps has a protective effect.

scholarly journals 2-Deprenyl-Rheediaxanthone B Isolated from Metaxya rostrata Induces Active Cell Death in Colorectal Tumor Cells

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e65745 ◽  
Author(s):  
Kerstin P. Kainz ◽  
Liselotte Krenn ◽  
Zeynep Erdem ◽  
Hanspeter Kaehlig ◽  
Martin Zehl ◽  
...  
Keyword(s):  
Cell Death ◽  
Tumor Cells ◽  
Colorectal Tumor ◽  
Active Cell ◽  
Active Cell Death
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