Urinary metabolite profile of antipyrine as a tool in the assessment of oxidative drug metabolizing capacity of man

1980 ◽  
pp. 176-186 ◽  
Author(s):  
M. Danhof ◽  
D. D. Breimer
1998 ◽  
Vol 11 (2) ◽  
pp. 111-118 ◽  
Author(s):  
Ben M. de Rooij ◽  
Jan N. M. Commandeur ◽  
John W. Hommes ◽  
Tom Aalbers ◽  
Ed J. Groot ◽  
...  

1994 ◽  
Vol 17 (1) ◽  
pp. 142-145 ◽  
Author(s):  
A. H. van Gennip ◽  
N. G. G. M. Abeling ◽  
A. E. M. Stroomer ◽  
H. Overmars ◽  
H. D. Bakker

1985 ◽  
Vol 19 (2) ◽  
pp. 225-232 ◽  
Author(s):  
J Blanchard ◽  
SJ Sawers ◽  
JH Jonkman ◽  
DD Tang-Liu

1984 ◽  
Vol 3 (6) ◽  
pp. 485-495 ◽  
Author(s):  
J.A. Timbrell ◽  
J.M. Wright

1 The urinary metabolite profile of isoniazid has been studied in patients receiving the drug as therapy for tuberculosis and the profile in patients suffering liver damage due to isoniazid compared with that in control patients. 2 There were no consistent differences between control patients and those suffering liver damage in the excretion of isoniazid metabolites. 3 It may be that susceptibility to the hepatotoxicity of isoniazid is not due to metabolic differences, although a number of other possible explanations are discussed. 4 It is not at present possible to predict which patients will be susceptible from metabolic studies.


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