The role of biological markers in the early and differential diagnosis of Alzheimer’s disease

2002 ◽  
pp. 127-133 ◽  
Author(s):  
A. Kurz ◽  
M. Riemenschneider ◽  
A. Drzezga ◽  
N. Lautenschlager
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Differential Diagnosis ◽  
Biological Markers

Biological markers for differential diagnosis of Alzheimer’s disease and related disorders

2001 ◽  
pp. 267-273
Author(s):  
Masatoshi Takeda ◽  
Takashi Kudo ◽  
Yu Nakamura ◽  
Toshihisa Tanaka ◽  
Takashi Nishikawa ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Differential Diagnosis ◽  
Biological Markers

Differential diagnosis between Alzheimer's disease and other dementias: Role of cerebrospinal fluid biomarkers

2019 ◽  
Vol 72 ◽  
pp. 24-29
Author(s):  
Lucia Farotti ◽  
Federica Nicoletta Sepe ◽  
Andrea Toja ◽  
Roberta Rinaldi ◽  
Lucilla Parnetti
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Differential Diagnosis ◽  
Cerebrospinal Fluid Biomarkers

Potential Role of Diffusion Tensor MRI in the Differential Diagnosis of Mild Cognitive Impairment and Alzheimer's Disease

2008 ◽  
Vol 190 (5) ◽  
pp. 1369-1374 ◽  
Author(s):  
Daniella B. Parente ◽  
Emerson L. Gasparetto ◽  
Luiz Celso Hygino da Cruz ◽  
Roberto Cortes Domingues ◽  
Ana Célia Baptista ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Differential Diagnosis ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Potential Role ◽  
Diffusion Tensor ◽  
Diffusion Tensor Mri

Reevaluating the Role of Vascular Changes in the Differential Diagnosis of Alzheimer’s Disease and Vascular Dementia

1998 ◽  
Vol 40 (3) ◽  
pp. 121-129 ◽  
Author(s):  
Gabriel Gold ◽  
Panteleimon Giannakopoulos ◽  
Constantin Bouras
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Differential Diagnosis ◽  
Vascular Dementia ◽  
Vascular Changes

scholarly journals Role of neuropsychological assessment in the differential diagnosis of Alzheimer's disease and vascular dementia

2009 ◽  
Vol 3 (3) ◽  
pp. 214-221 ◽  
Author(s):  
Érica Maria Lima Pimentel
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Differential Diagnosis ◽  
Cognitive Function ◽  
Vascular Dementia ◽  
Neuropsychological Assessment ◽  
Neurological Examination ◽  
Cognitive Changes ◽  
Neuropsychological Assessments

Abstract The prevalence of dementia increases significantly from the age of 65 years, doubling every five years thereafter. Alzheimer's disease (AD) and vascular dementia (VaD) constitute the two main dementia types. Differentiating them encompasses anamnesis, neurological examination, laboratory and neuroimaging exams and neuropsychological assessment. Neuropsychological assessment produces different findings for each dementia type, and reveals those areas most impaired as well as those most preserved. The aim of the present article was to describe the role of neuropsychology in diagnosing dementia and achieving a differential diagnosis between AD and VaD. A general overview follows of the most widely known instruments used to assess cognitive function in dementia, and the cognitive changes seen in AD and VaD. The conclusion drawn was that there is significant overlap in cognitive changes between both these dementia types, while each type has its own specific characteristics which are identifiable and quantifiable on neuropsychological assessments and provide the basis for reaching a differential diagnosis.

scholarly journals Positron Emission Tomography (PET) and Neuroimaging in the Personalized Approach to Neurodegenerative Causes of Dementia

2020 ◽  
Vol 21 (20) ◽  
pp. 7481 ◽  
Author(s):  
Maria Ricci ◽  
Andrea Cimini ◽  
Agostino Chiaravalloti ◽  
Luca Filippi ◽  
Orazio Schillaci
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Positron Emission Tomography ◽  
Differential Diagnosis ◽  
Emission Tomography ◽  
Treatment Management ◽  
Positron Emission ◽  
Appropriate Therapy ◽  
Personalized Approach

Generally, dementia should be considered an acquired syndrome, with multiple possible causes, rather than a specific disease in itself. The leading causes of dementia are neurodegenerative and non-neurodegenerative alterations. Nevertheless, the neurodegenerative group of diseases that lead to cognitive impairment and dementia includes multiple possibilities or mixed pathologies with personalized treatment management for each cause, even if Alzheimer’s disease is the most common pathology. Therefore, an accurate differential diagnosis is mandatory in order to select the most appropriate therapy approach. The role of personalized assessment in the treatment of dementia is rapidly growing. Neuroimaging is an essential tool for differential diagnosis of multiple causes of dementia and allows a personalized diagnostic and therapeutic protocol based on risk factors that may improve treatment management, especially in early diagnosis during the prodromal stage. The utility of structural and functional imaging could be increased by standardization of acquisition and analysis methods and by the development of algorithms for automated assessment. The aim of this review is to focus on the most commonly used tracers for differential diagnosis in the dementia field. Particularly, we aim to explore 18F Fluorodeoxyglucose (FDG) and amyloid positron emission tomography (PET) imaging in Alzheimer’s disease and in other neurodegenerative causes of dementia.

scholarly journals Perspective on future role of biological markers in clinical therapy trials of Alzheimer's disease: A long-range point of view beyond 2020

2014 ◽  
Vol 88 (4) ◽  
pp. 426-449 ◽  
Author(s):  
Harald Hampel ◽  
Simone Lista ◽  
Stefan J. Teipel ◽  
Francesco Garaci ◽  
Robert Nisticò ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Long Range ◽  
Biological Markers ◽  
Point Of View ◽  
Future Role ◽  
Clinical Therapy

P2-094: The role of ASL-measured cerebral blood flow in the differential diagnosis of Alzheimer's disease, frontotemporal dementia and dementia with Lewy bodies

2013 ◽  
Vol 9 ◽  
pp. P377-P377
Author(s):  
Maja Binnewijzend ◽  
Joost Kuijer ◽  
Wiesje Van der Flier ◽  
Marije Benedictus ◽  
Christiane Möller ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Differential Diagnosis ◽  
Cerebral Blood Flow ◽  
Frontotemporal Dementia ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies

Biological markers as outcome measures for Alzheimer's disease interventions – real problems and future possibilities

2007 ◽  
Vol 19 (3) ◽  
pp. 391-400 ◽  
Author(s):  
Masatoshi Takeda ◽  
Masayasu Okochi ◽  
Shinji Tagami ◽  
Toshihisa Tanaka ◽  
Takashi Kudo
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Differential Diagnosis ◽  
Biological Markers ◽  
Surrogate Marker ◽  
Biological Marker ◽  
Pathological Process ◽  
Clinical Onset ◽  
Diagnosis Of Dementia ◽  
And Biological Markers

Because the biological pathological process is observed decades years before the clinical onset of Alzheimer's disease (AD), there is a theoretical ad-vantage in using biological markers for the early diagnosis of AD. Neuro-psychological test batteries, brain imaging and biological markers are expected to be used for screening and differential diagnosis of dementia and also for evaluation of the efficacy of early intervention.No single biological marker can serve all the purposes of screening, differential diagnosis and measurement of severity. Biological markers that reflect molecular stress, such as oxidative, ribotoxic, and nitroso stress, need to be developed, particularly for measuring the clinical outcomes of interventions. As well as providing a better understanding of the molecular pathogenesis of AD, there is a possibility of finding a surrogate marker of AD, which might fulfill the requirement of sufficient sensitivity and specificity for AD diagnosis, as well as indicating the disease-modifying activity of interventions. In this study we examine whether the mechanism of secretase activity will offer a new surrogate marker of AD.

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