Interneurons in the Olfactory Bulb: Roles in the Plasticity of Olfactory Information Processing

2014 ◽  
pp. 97-132
Author(s):  
Masahiro Yamaguchi
Keyword(s):  
Information Processing ◽  
Olfactory Bulb ◽  
Olfactory Information

Olfactory information processing, odor-modulated behavior, and their plasticity in the moth Manduca sexta

2009 ◽  
Vol 153 (2) ◽  
pp. S155-S156
Author(s):  
John G. Hildebrand ◽  
Joshua P. Martin ◽  
Carolina E. Reisenman ◽  
Hong Lei ◽  
Jeffrey A. Riffell
Keyword(s):  
Information Processing ◽  
Manduca Sexta ◽  
Olfactory Information

scholarly journals Differential impacts of repeated sampling on odor representations by genetically-defined mitral and tufted cell subpopulations in the mouse olfactory bulb

2020 ◽  
Author(s):  
Thomas P. Eiting ◽  
Matt Wachowiak
Keyword(s):  
Information Processing ◽  
Olfactory Bulb ◽  
High Frequency ◽  
Response Patterns ◽  
Repeated Sampling ◽  
Tufted Cell ◽  
Cell Subpopulations ◽  
Genetic Targeting ◽  
The Impact ◽  
Over Time

AbstractSniffing—the active control of breathing beyond passive respiration—is used by mammals to modulate olfactory sampling. Sniffing allows animals to make odor-guided decisions within ~200 ms, but animals routinely engage in bouts of high-frequency sniffing spanning several seconds; the impact of such repeated odorant sampling on odor representations remains unclear. We investigated this question in the mouse olfactory bulb, where mitral and tufted cells (MTCs) form parallel output streams of odor information processing. To test the impact of repeated odorant sampling on MTC responses, we used two-photon imaging in anesthetized male and female mice to record activation of MTCs while precisely varying inhalation frequency. A combination of genetic targeting and viral expression of GCaMP6 reporters allowed us to access mitral (MC) and superficial tufted cell (sTC) subpopulations separately. We found that repeated odorant sampling differentially affected responses in MCs and sTCs, with MCs showing more diversity than sTCs over the same time period. Impacts of repeated sampling among MCs included both increases and decreases in excitation, as well as changes in response polarity. Response patterns across ensembles of simultaneously-imaged MCs reformatted over time, with representations of different odorants becoming more distinct. MCs also responded differentially to changes in inhalation frequency, whereas sTC responses were more uniform over time and across frequency. Our results support the idea that MCs and TCs comprise functionally distinct pathways for odor information processing, and suggest that the reformatting of MC odor representations by high-frequency sniffing may serve to enhance the discrimination of similar odors.

Homomeric RDL and Heteromeric RDL/LCCH3 GABA Receptors in the Honeybee Antennal Lobes: Two Candidates for Inhibitory Transmission in Olfactory Processing

2010 ◽  
Vol 103 (1) ◽  
pp. 458-468 ◽  
Author(s):  
Julien Pierre Dupuis ◽  
Michaël Bazelot ◽  
Guillaume Stéphane Barbara ◽  
Sandrine Paute ◽  
Monique Gauthier ◽  
...  
Keyword(s):  
Information Processing ◽  
Chloride Channel ◽  
Gaba Receptors ◽  
Gaba Receptor ◽  
Chloride Channels ◽  
Physiological Role ◽  
Inhibitory Transmission ◽  
Olfactory Information ◽  
Whole Cell Patch Clamp ◽  
Inward Currents

γ-Aminobutyric acid (GABA)–gated chloride channel receptors are abundant in the CNS, where their physiological role is to mediate fast inhibitory neurotransmission. In insects, this inhibitory transmission plays a crucial role in olfactory information processing. In an effort to understand the nature and properties of the ionotropic receptors involved in these processes in the honeybee Apis mellifera, we performed a pharmacological and molecular characterization of GABA-gated channels in the primary olfactory neuropile of the honeybee brain—the antennal lobe (AL)—using whole cell patch-clamp recordings coupled with single-cell RT-PCR. Application of GABA onto AL cells at −110 mV elicited fast inward currents, demonstrating the existence of ionotropic GABA-gated chloride channels. Molecular analysis of the GABA-responding cells revealed that both subunits RDL and LCCH3 were expressed out of the three orthologs of Drosophila melanogaster GABA-receptor subunits encoded within the honeybee genome (RDL, resistant to dieldrin; GRD, GABA/glycine-like receptor of Drosophila ; LCCH3, ligand-gated chloride channel homologue 3), opening the door to possible homo- and/or heteromeric associations. The resulting receptors were activated by insect GABA-receptor agonists muscimol and CACA and blocked by antagonists fipronil, dieldrin, and picrotoxin, but not bicuculline, displaying a typical RDL-like pharmacology. Interestingly, increasing the intracellular calcium concentration potentiated GABA-elicited currents, suggesting a modulating effect of calcium on GABA receptors possibly through phosphorylation processes that remain to be determined. These results indicate that adult honeybee AL cells express typical RDL-like GABA receptors whose properties support a major role in synaptic inhibitory transmission during olfactory information processing.

Olfactory information processing in honeybee, Apis mellifera, nestmate recognition

2004 ◽  
Vol 68 (4) ◽  
pp. 921-928 ◽  
Author(s):  
Michael D. Breed ◽  
Patrick H. Diaz ◽  
Kristine D. Lucero
Keyword(s):  
Information Processing ◽  
Apis Mellifera ◽  
Nestmate Recognition ◽  
Olfactory Information

scholarly journals Odor Information Processing by the Olfactory Bulb Analyzed in Gene-Targeted Mice

Neuron ◽  
2010 ◽  
Vol 65 (6) ◽  
pp. 912-926 ◽  
Author(s):  
Jie Tan ◽  
Agnès Savigner ◽  
Minghong Ma ◽  
Minmin Luo
Keyword(s):  
Information Processing ◽  
Olfactory Bulb

Odor Information Processing in the Olfactory Bulb.

1987 ◽  
Vol 510 (1 Olfaction and) ◽  
pp. 400-402 ◽  
Author(s):  
J. S. KAUER ◽  
K. A. HAMILTON
Keyword(s):  
Information Processing ◽  
Olfactory Bulb
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