Recombinant Human Hepatocyte Growth Factor Promotes Functional Recovery After Spinal Cord Injury

2014 ◽  
pp. 147-167 ◽  
Author(s):  
Kazuya Kitamura ◽  
Akio Iwanami ◽  
Kanehiro Fujiyoshi ◽  
Jun-ichi Yamane ◽  
Keigo Hikishima ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Functional Recovery ◽  
Human Hepatocyte ◽  
Cord Injury ◽  
Human Hepatocyte Growth Factor ◽  
Hepatocyte Growth

scholarly journals Human Hepatocyte Growth Factor Promotes Functional Recovery in Primates after Spinal Cord Injury

PLoS ONE ◽  
2011 ◽  
Vol 6 (11) ◽  
pp. e27706 ◽  
Author(s):  
Kazuya Kitamura ◽  
Kanehiro Fujiyoshi ◽  
Jun-ichi Yamane ◽  
Fumika Toyota ◽  
Keigo Hikishima ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Functional Recovery ◽  
Human Hepatocyte ◽  
Cord Injury ◽  
Human Hepatocyte Growth Factor ◽  
Hepatocyte Growth

Hepatocyte growth factor promotes endogenous repair and functional recovery after spinal cord injury

2007 ◽  
Vol 85 (11) ◽  
pp. 2332-2342 ◽  
Author(s):  
Kazuya Kitamura ◽  
Akio Iwanami ◽  
Masaya Nakamura ◽  
Junichi Yamane ◽  
Kota Watanabe ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Functional Recovery ◽  
Cord Injury ◽  
Hepatocyte Growth

scholarly journals Multipotent Neurotrophic Effects of Hepatocyte Growth Factor in Spinal Cord Injury

2019 ◽  
Vol 20 (23) ◽  
pp. 6078 ◽  
Author(s):  
Kentaro Yamane ◽  
Haruo Misawa ◽  
Tomoyuki Takigawa ◽  
Yoshihiro Ito ◽  
Toshifumi Ozaki ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Stem Cell Differentiation ◽  
Neural Regeneration ◽  
Therapeutic Effects ◽  
Positive Effects ◽  
Cord Injury ◽  
Hepatocyte Growth

Spinal cord injury (SCI) results in neural tissue loss and so far untreatable functional impairment. In addition, at the initial injury site, inflammation induces secondary damage, and glial scar formation occurs to limit inflammation-mediated tissue damage. Consequently, it obstructs neural regeneration. Many studies have been conducted in the field of SCI; however, no satisfactory treatment has been established to date. Hepatocyte growth factor (HGF) is one of the neurotrophic growth factors and has been listed as a candidate medicine for SCI treatment. The highlighted effects of HGF on neural regeneration are associated with its anti-inflammatory and anti-fibrotic activities. Moreover, HGF exerts positive effects on transplanted stem cell differentiation into neurons. This paper reviews the mechanisms underlying the therapeutic effects of HGF in SCI recovery, and introduces recent advances in the clinical applications of HGF therapy.

scholarly journals Application of Hepatocyte Growth Factor for Acute Spinal Cord Injury: The Road from Basic Studies to Human Treatment

2019 ◽  
Vol 20 (5) ◽  
pp. 1054 ◽  
Author(s):  
Kazuya Kitamura ◽  
Narihito Nagoshi ◽  
Osahiko Tsuji ◽  
Morio Matsumoto ◽  
Hideyuki Okano ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Acute Phase ◽  
Viral Vector ◽  
Hand Function ◽  
Common Marmoset ◽  
Cord Injury ◽  
Hepatocyte Growth

Hepatocyte growth factor (HGF) was first identified as a potent mitogen for mature hepatocytes, and has also gained attention as a strong neurotrophic factor in the central nervous system. We found that during the acute phase of spinal cord injury (SCI) in rats, c-Met, the specific receptor for HGF, increases sharply, while the endogenous HGF up-regulation is relatively weak. Introducing exogenous HGF into the spinal cord by injecting an HGF-expressing viral vector significantly increased the neuron and oligodendrocyte survival, angiogenesis, and axonal regeneration, to reduce the area of damage and to promote functional recovery in rats after SCI. Other recent studies in rodents have shown that exogenously administered HGF during the acute phase of SCI reduces astrocyte activation to decrease glial scar formation, and exerts anti-inflammatory effects to reduce leukocyte infiltration. We also reported that the intrathecal infusion of recombinant human HGF (intrathecal rhHGF) improves neurological hand function after cervical contusive SCI in the common marmoset, a non-human primate. Based on these collective results, we conducted a phase I/II clinical trial of intrathecal rhHGF for patients with acute cervical SCI who showed a modified Frankel grade of A/B1/B2 72 h after injury onset, from June 2014 to May 2018.

Hepatocyte growth factor reduces astrocytic scar formation and promotes axonal growth beyond glial scars after spinal cord injury

2012 ◽  
Vol 233 (1) ◽  
pp. 312-322 ◽  
Author(s):  
Soo Ryeong Jeong ◽  
Min Jung Kwon ◽  
Hwan Goo Lee ◽  
Eun Hye Joe ◽  
Jae Ho Lee ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Axonal Growth ◽  
Scar Formation ◽  
Cord Injury ◽  
Glial Scars ◽  
Hepatocyte Growth

Expression of hepatocyte growth factor and c-Met after spinal cord injury in rats

2007 ◽  
Vol 1151 ◽  
pp. 188-194 ◽  
Author(s):  
Munehisa Shimamura ◽  
Naoyuki Sato ◽  
Masataka Sata ◽  
Kouji Wakayama ◽  
Toshio Ogihara ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Cord Injury ◽  
Hepatocyte Growth

Molecular cloning and expression of human hepatocyte growth factor

Nature ◽  
1989 ◽  
Vol 342 (6248) ◽  
pp. 440-443 ◽  
Author(s):  
Toshikazu Nakamura ◽  
Tsutomu Nishizawa ◽  
Mitchio Hagiya ◽  
Tatsuya Seki ◽  
Manabu Shimonishi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Molecular Cloning ◽  
Human Hepatocyte ◽  
Cloning And Expression ◽  
Human Hepatocyte Growth Factor ◽  
Hepatocyte Growth
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