Myocardial ischaemia and cardiac function

2003 ◽  
pp. 725-735
Author(s):  
P. Foëx
Keyword(s):  
Cardiac Function ◽  
Myocardial Ischaemia

scholarly journals Salvianolic acid B protects against myocardial ischaemia-reperfusion injury in rats via inhibiting high mobility group box 1 protein expression through the PI3K/Akt signalling pathway

2019 ◽  
Vol 393 (8) ◽  
pp. 1527-1539 ◽  
Author(s):  
Hanqing Liu ◽  
Wei Liu ◽  
Huiliang Qiu ◽  
Dezhi Zou ◽  
Huayang Cai ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Myocardial Ischaemia ◽  
Myocardial Injury ◽  
High Mobility ◽  
Salvianolic Acid B ◽  
High Mobility Group ◽  
High Dose ◽  
Dependent Manner ◽  
Salvianolic Acid ◽  
Ischaemia Reperfusion

AbstractSalvianolic acid B (Sal B) has a significant protective effect on myocardial ischaemia-reperfusion (I/R) injury. Therefore, the aims of this study were to determine the effects of Sal B on myocardial ischaemic-reperfusion (I/R) injury in rats and to explore whether its underlying mechanism of cardioprotection occurs through activating the expression of the phosphoinositide 3-kinase/protein, kinase B (PI3K/Akt) and inhibiting the expression of high mobility group protein 1 (HMGB1). Ninety Sprague-Dawley rats were randomized into five groups: group 1 (sham-operated), group 2 (myocardial I/R), group 3 (low dose of Sal B+I/R), group 4 (high dose of Sal B+I/R), and group 5 (high dose of Sal B+I/R+LY294002, which is a specific PI3k inhibitor). All I/R rats received 30 min myocardial ischaemia followed by 24-h reperfusion. Cardiac function, infarct size, myocardial injury marker levels, inflammatory response and cardiomyocyte apoptosis as well as Bcl-2, Bax, P-Akt, HMGB1 and TLR4 expression were measured. In the current study, Sal B significantly ameliorated myocardial I/R injury in a dose-dependent manner, ameliorated cardiac function, reduced myocardial infarction size, decreased myocardial injury marker expression, decreased inflammatory responses, reduced apoptosis, activated PI3K/Akt expression and inhibited HMGB1 expression. However, all effects of Sal B were significantly reversed by LY294002. Overall, the present study indicated that Sal B attenuated myocardial I/R injury by activating PI3K/Akt and inhibiting the release of HMGB1 in rats.

scholarly journals Hypoxia-preconditioned mesenchymal stromal cells improve cardiac function in a swine model of chronic myocardial ischaemia

2012 ◽  
Vol 43 (5) ◽  
pp. 1050-1057 ◽  
Author(s):  
Jeremie Jaussaud ◽  
Matthieu Biais ◽  
Joachim Calderon ◽  
Jean Chevaleyre ◽  
Pascale Duchez ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Mesenchymal Stromal Cells ◽  
Myocardial Ischaemia ◽  
Stromal Cells ◽  
Swine Model

scholarly journals Pharmacological activation of the prostaglandin E2 receptor EP4 improves cardiac function after myocardial ischaemia/reperfusion injury

2008 ◽  
Vol 81 (1) ◽  
pp. 123-132 ◽  
Author(s):  
Keiichi Hishikari ◽  
Jun-ichi Suzuki ◽  
Masahito Ogawa ◽  
Kazuya Isobe ◽  
Teisuke Takahashi ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Prostaglandin E2 ◽  
Reperfusion Injury ◽  
Myocardial Ischaemia ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion ◽  
Prostaglandin E2 Receptor

scholarly journals THE EFFECT OF TIROFIBAN ON CARDIAC FUNCTION AFTER MYOCARDIAL ISCHAEMIA REPERFUSION IN DOGS

Heart ◽  
2012 ◽  
Vol 98 (Suppl 2) ◽  
pp. E97.1-E97
Author(s):  
Wang Zi-liang ◽  
Wang Xiao-ping ◽  
Xie Dong-yang
Keyword(s):  
Cardiac Function ◽  
Myocardial Ischaemia ◽  
Ischaemia Reperfusion

551 Bromocriptine prevents deterioration of cardiac function in patients with PPCM after subsequent pregnancy

2006 ◽  
Vol 5 (1) ◽  
pp. 122-123
Author(s):  
O FORSTER ◽  
D HILFIKERKLEINER ◽  
A YIP ◽  
A BECKER ◽  
M NEL ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Subsequent Pregnancy
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