Too Late to Matter? Preventing the Birth of Infants at Risk for Adult-Onset Disease or Disability

2009 ◽  
pp. 109-122
Author(s):  
Laura M. Purdy
Keyword(s):  
At Risk ◽  
Adult Onset

scholarly journals What Have Slow Progressors Taught Us About T1D—Mind the Gap!

2019 ◽  
Vol 19 (10) ◽  
Author(s):  
Kathleen M. Gillespie ◽  
Anna E. Long
Keyword(s):  
At Risk ◽  
Clinical Symptoms ◽  
Adult Population ◽  
Islet Autoimmunity ◽  
Islet Autoantibody ◽  
Progression Rate ◽  
Adult Onset ◽  
Genetic Studies ◽  
Slow Progressors

Abstract Purpose of Review Progression rate from islet autoimmunity to clinical diabetes is unpredictable. In this review, we focus on an intriguing group of slow progressors who have high-risk islet autoantibody profiles but some remain diabetes free for decades. Recent Findings Birth cohort studies show that islet autoimmunity presents early in life and approximately 70% of individuals with multiple islet autoantibodies develop clinical symptoms of diabetes within 10 years. Some “at risk” individuals however progress very slowly. Recent genetic studies confirm that approximately half of type 1 diabetes (T1D) is diagnosed in adulthood. This creates a conundrum; slow progressors cannot account for the number of cases diagnosed in the adult population. Summary There is a large “gap” in our understanding of the pathogenesis of adult onset T1D and a need for longitudinal studies to determine whether there are “at risk” adults in the general population; some of whom are rapid and some slow adult progressors.

Presymptomatic testing for adult onset polycystic kidney disease in at-risk kidney transplant donors

1991 ◽  
Vol 40 (4) ◽  
pp. 425-428 ◽  
Author(s):  
Vickie L. Hannig ◽  
Jeanne R. Hopkins ◽  
H. Keith Johnson ◽  
John A. Phillips ◽  
Stephen T. Reeders
Keyword(s):  
At Risk ◽  
Kidney Disease ◽  
Kidney Transplant ◽  
Polycystic Kidney Disease ◽  
Adult Onset ◽  
Polycystic Kidney ◽  
Presymptomatic Testing

Non-atopic males with adult onset asthma are at risk of persistent airflow limitation

2012 ◽  
Vol 42 (5) ◽  
pp. 769-774 ◽  
Author(s):  
M. Amelink ◽  
S. B. de Nijs ◽  
M. Berger ◽  
E. J. Weersink ◽  
A. ten Brinke ◽  
...  
Keyword(s):  
At Risk ◽  
Airflow Limitation ◽  
Adult Onset

Genetic Testing of Children at Risk for Adult Onset Conditions: When is Testing Indicated?

2008 ◽  
Vol 17 (6) ◽  
pp. 523-525 ◽  
Author(s):  
N. Lwiwski ◽  
C. R. Greenberg ◽  
A. A. Mhanni
Keyword(s):  
At Risk ◽  
Genetic Testing ◽  
Adult Onset ◽  
Children At Risk

Nasal Polyposis Identifies An At Risk Phenotype Among Patients With Adult-Onset Asthma

2011 ◽  
Author(s):  
Marijke Amelink ◽  
SB de Nijs ◽  
Christa de Groot ◽  
Saeeda Lone-Laktif ◽  
S.M. Reinartz ◽  
...  
Keyword(s):  
At Risk ◽  
Nasal Polyposis ◽  
Adult Onset

Prevalence of diabetes-specific autoantibodies in patients at risk for adult onset diabetes mellitus

2009 ◽  
Vol 106 (02) ◽  
pp. 113-116 ◽  
Author(s):  
M. Breidert ◽  
Th. Temelkova-Kurktschiev ◽  
M. Hanefeld ◽  
W. Leonhardt ◽  
A. Schmoeckel ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
At Risk ◽  
Adult Onset ◽  
Onset Diabetes ◽  
Patients At Risk ◽  
Adult Onset Diabetes

Early Detection and Intervention of Psychosis: the Child and Adolescent Perspective

2011 ◽  
Vol 26 (S2) ◽  
pp. 2011-2011
Author(s):  
B.G. Schimmelmann
Keyword(s):  
At Risk ◽  
Early Detection ◽  
Children And Adolescents ◽  
Age Groups ◽  
Child And Adolescent ◽  
Clinical Samples ◽  
First Episode ◽  
Adult Onset ◽  
Risk Criteria ◽  
Episode Psychosis

Over the last two decades, much progress in the prevention and early detection of first-episode psychosis has been achieved. And currently, the inclusion of a psychosis risk syndrome in DSM-V is discussed. But while differences between early-onset and adult-onset psychoses have frequently been pointed out, in the early detection of psychoses, developmental aspects are rarely considered, and results that have been derived from predominately adult samples, i.e., at-risk criteria are generally just transferred to children and adolescents. Emerging evidence from child and adolescent general population, birth cohort and clinical samples, however, question this unrestricted transferability of these results to younger age groups. This presentation will therefore outline the special aspects in the early detection of psychosis that should be considered in children and adolescents. The presentation will cover (i) evidence for the need of a validation of at-risk criteria in children and adolescents and (ii) evidence for a longer DUP in adolescent onset compared to adult onset psychosis and its clinical implications.

Phonological Awareness Screening to Identify At-Risk Readers

1998 ◽  
Vol 29 (2) ◽  
pp. 109-116 ◽  
Author(s):  
Margie Gilbertson ◽  
Ronald K. Bramlett
Keyword(s):  
At Risk ◽  
Phonological Awareness ◽  
Reading Ability ◽  
At Risk Students ◽  
First Grade ◽  
Receptive Vocabulary ◽  
Standardized Assessments ◽  
Cutoff Score ◽  
Invented Spelling ◽  
Reading Measures

The purpose of this study was to investigate informal phonological awareness measures as predictors of first-grade broad reading ability. Subjects were 91 former Head Start students who were administered standardized assessments of cognitive ability and receptive vocabulary, and informal phonological awareness measures during kindergarten and early first grade. Regression analyses indicated that three phonological awareness tasks, Invented Spelling, Categorization, and Blending, were the most predictive of standardized reading measures obtained at the end of first grade. Discriminant analyses indicated that these three phonological awareness tasks correctly identified at-risk students with 92% accuracy. Clinical use of a cutoff score for these measures is suggested, along with general intervention guidelines for practicing clinicians.

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