Natural Inhibitors of Snake Venom Metallopeptidases

2015 ◽  
pp. 1-23
Author(s):  
Ana G. C. Neves-Ferreira ◽  
Richard H. Valente ◽  
Gilberto B. Domont ◽  
Jonas Perales
Keyword(s):  
Snake Venom ◽  
Natural Inhibitors

Natural Inhibitors of Snake Venom Metallopeptidases

2017 ◽  
pp. 53-80
Author(s):  
Ana G. C. Neves-Ferreira ◽  
Richard H. Valente ◽  
Gilberto B. Domont ◽  
Jonas Perales
Keyword(s):  
Snake Venom ◽  
Natural Inhibitors

Natural inhibitors of snake venom hemorrhagic metalloproteinases

Toxicon ◽  
2005 ◽  
Vol 45 (8) ◽  
pp. 1013-1020 ◽  
Author(s):  
Jonas Perales ◽  
Ana G.C. Neves-Ferreira ◽  
Richard H. Valente ◽  
Gilberto B. Domont
Keyword(s):  
Snake Venom ◽  
Natural Inhibitors

scholarly journals Natural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challenges

Toxins ◽  
2016 ◽  
Vol 8 (9) ◽  
pp. 250 ◽  
Author(s):  
Viviane Bastos ◽  
Francisco Gomes-Neto ◽  
Jonas Perales ◽  
Ana Neves-Ferreira ◽  
Richard Valente
Keyword(s):  
Snake Venom ◽  
Natural Inhibitors

Natural Inhibitors of Snake Venom Metalloproteinases

2020 ◽  
Vol 73 (4) ◽  
pp. 277
Author(s):  
Narumi Aoki-Shioi ◽  
Cho Yeow Koh ◽  
R. Manjunatha Kini
Keyword(s):  
Snake Venom ◽  
Broad Spectrum ◽  
Selective Inhibitors ◽  
Severe Haemorrhage ◽  
Lack Of Information ◽  
Inhibitory Mechanisms ◽  
Hemorrhagic Activity ◽  
Competitive Inhibitors ◽  
Natural Inhibitors ◽  
Specific Inhibitors

Snakebites are a hazard in the tropical world. Although antivenom therapy is effective, it is beset with inherent drawbacks. A better understanding of the major components of snake venoms and their neutralisation will help in improving snakebite treatment. Snake venom metalloproteinases (SVMPs) are responsible for severe haemorrhage, the inhibition of coagulation and platelet aggregation, observed in the victims of snakebite envenoming. Inhibitors from various sources including medicinal plants, animal venoms, and sera are sought to block the pharmacological functions of SVMPs. In this review, we describe the interaction of natural inhibitors with SVMPs. To understand their inhibitory mechanisms, we focussed on the complex structures of these inhibitors and SVMPs. There are three distinct classes of inhibitors; namely, chelators, competitive inhibitors, and non-competitive inhibitors. A small number of inhibitors show their anti-hemorrhagic activity in invivo animal models in treatment mode, but most studies evaluate either invitro neutralisation of enzymatic activity or invivo effects in pre-incubation protocols. We propose the distinct strategies and limitations to design either broad-spectrum or highly selective SVMP inhibitors. The goal of designing broad-spectrum inhibitors against SVMPs capable of effective treatment of snakebites without toxicity has been elusive, probably because of the narrow molecular footprint of inhibitors against a large number of SVMPs with distinct molecular surfaces. Our ability to design highly selective inhibitors is limited by the lack of information of interactions between selective inhibitors and SVMPs. Comparisons of structures of hemorrhagic and non-hemorrhagic SVMPs revealed different distributions of electric charge on the surface of SVMPs, which may be exploited to design specific inhibitors. The specific inhibitors may also be useful to identify target molecules of the SVMPs and help to understand their mechanism of action.

scholarly journals Patofisiologi Bisa Ular dan Aplikasi Terapi Tumbuhan Obat Antiophidia (Antibisa)

2018 ◽  
Vol 6 (2) ◽  
pp. 80-90
Author(s):  
Aditya K. Karim ◽  
Ervina Indrayani ◽  
Laila Hanum
Keyword(s):  
Natural Products ◽  
Medicinal Plant ◽  
Snake Venom ◽  
Snake Bite ◽  
Morbidity And Mortality ◽  
Major Health ◽  
Venomous Snake ◽  
Valuable Source ◽  
The World ◽  
Natural Inhibitors

Venomous snakebite is an important cause of morbidity and mortality, and is one of the major health problems in many regions of the world. Medicinal Plant which are effectively inhibitor and neutralize the snake venom and it is considered as a valuable source of natural products for development of medicines against venomous snake bite. The biomedical value of these natural inhibitors can lead to the development of new therapeutics for an assortment of diseases as well as contributing to efficient antivenoms for the treatment of ophidic accidents.Key words: pathophysiology, snake bite, envenomation, medicinal plant, therapeutic. 

Quinovic Acid Glycosides From MitraGyna Stipulosa - First Examples of Natural Inhibitors of Snake Venom Phosphodiesterase I

2002 ◽  
Vol 16 (6) ◽  
pp. 389-393 ◽  
Author(s):  
Naheed Fatima ◽  
Leon Azefack Tapondjou ◽  
David Lontsi ◽  
B.L. Sondengam ◽  
Atta-Ur-Rahman ◽  
...  
Keyword(s):  
Snake Venom ◽  
Snake Venom Phosphodiesterase ◽  
Natural Inhibitors

scholarly journals Therapeutic application of natural inhibitors against snake venom phospholipase A2

2012 ◽  
Vol 8 (1) ◽  
pp. 48-57 ◽  
Author(s):  
Ramar Perumal Samy ◽  
Ponnampalam Gopalakrishnakone ◽  
Vincent TK Chow
Keyword(s):  
Phospholipase A2 ◽  
Snake Venom ◽  
Therapeutic Application ◽  
Snake Venom Phospholipase ◽  
Natural Inhibitors
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