To study the evolution of meso-structure of unsaturated intact loess during wetting, a series of CT-triaxial-collapse tests were conducted using CT-multi-function triaxial apparatus. The distinct CT images and detailed CT data were attained nondestructively during wetting. A parameter and an evolution variable which characterized evolution of meso-structure were defined based CT data. An equation describing the evolution of structure during wetting was proposed. The equation reflected the influences of net cell stress, deviatoric stress and suction on the evolution of meso-structure. In the equation, volumetric strain, deviatoric strain and incremental degree of saturation are included.