Time-Resolved Applications of Synchrotron Radiation in Protein Crystallography

1988 ◽  
pp. 487-507
Author(s):  
H. D. Bartunik
Keyword(s):  
Synchrotron Radiation ◽  
Protein Crystallography ◽  
Time Resolved

scholarly journals Synchrotron radiation macromolecular crystallography: our science and spin offs

2014 ◽  
Vol 70 (a1) ◽  
pp. C10-C10
Author(s):  
John Helliwell
Keyword(s):  
Synchrotron Radiation ◽  
Protein Complexes ◽  
Bound Water ◽  
Water Structure ◽  
Public Understanding ◽  
Anomalous Scattering ◽  
Structural Studies ◽  
Macromolecular Crystallography ◽  
Time Resolved ◽  
Chemical Crystallography

I will give an overview of synchrotron radiation (SR) in macromolecular crystallography (MX) instrumentation, methods and applications from the early days to the present, including the evolution of SR sources and on to the `ultimate storage ring'. The build of dedicated beamlines for resonant anomalous scattering, large unit cells, ever smaller crystals and studies up to ultra-high resolution are core benefits. Results include a high output of PDB depositions, the successful use of microcrystals, pushing the frontiers of using high and low photon energies and time-resolved structural studies at even sub-nanosecond resolutions. These intensively physics based developments will be complemented by biological and chemical crystallography research results, encompassing catalysis and marine coloration, as well as the public understanding of our science and its impacts. Spin off benefits include services to the pharmaceutical industry and helping develop chemical crystallography uses of SR. The development of the Laue method with SR has led to pioneering spin off developments in neutron MX, including transfer of the well validated Daresbury Laue software to various neutron facilities worldwide. Neutron MX is gathering pace as new instrumentation and dedicated sample preparation facilities are in place at reactor and spallation neutron sources; smaller samples and much larger molecular weight protein complexes are now feasible for investigation so as to establish their protonation states and bound water structure. With the X-ray lasers, closely linked to the SR developments, we anticipate the use of ever smaller samples such as nanocrystals, nanoclusters and single molecules, as well as opening up femtosecond time-resolved diffraction structural studies. At the SR sources, a very high throughput assessment for the best crystal samples and tackling sub-micron crystals will become widespread.

scholarly journals X-ray reflectivity with a twist: Quantitative time-resolved X-ray reflectivity using monochromatic synchrotron radiation

2019 ◽  
Vol 114 (8) ◽  
pp. 081904 ◽  
Author(s):  
Howie Joress ◽  
Shane Q. Arlington ◽  
Timothy P. Weihs ◽  
Joel D. Brock ◽  
Arthur R. Woll
Keyword(s):  
Synchrotron Radiation ◽  
Time Resolved ◽  
X Ray ◽  
Monochromatic Synchrotron

Multichannel FPGA-Based Data-Acquisition-System for Time-Resolved Synchrotron Radiation Experiments

2017 ◽  
Vol 64 (6) ◽  
pp. 1320-1326 ◽  
Author(s):  
Hyeokmin Choe ◽  
Semen Gorfman ◽  
Stefan Heidbrink ◽  
Ullrich Pietsch ◽  
Marco Vogt ◽  
...  
Keyword(s):  
Synchrotron Radiation ◽  
Data Acquisition ◽  
Data Acquisition System ◽  
Acquisition System ◽  
Time Resolved

Recent successes in time-resolved protein crystallography

2000 ◽  
Vol 17 (6) ◽  
pp. 527-533 ◽  
Author(s):  
Rupert C. Wilmouth ◽  
Ian J. Clifton ◽  
Richard Neutze
Keyword(s):  
Protein Crystallography ◽  
Time Resolved

High speed systems for time-resolved experiments with synchrotron radiation

2018 ◽  
Vol 13 (02) ◽  
pp. C02049-C02049 ◽  
Author(s):  
Anna Koziol ◽  
Piotr Maj
Keyword(s):  
Synchrotron Radiation ◽  
High Speed ◽  
Time Resolved

Time-resolved study of the lowest optically accessible ion-pair state of IBr using synchrotron radiation

1985 ◽  
Vol 31 (1) ◽  
pp. 1-5 ◽  
Author(s):  
R.J. Donovan ◽  
G. Gilbert ◽  
M. Macdonald ◽  
J.P.T. Wilkinson ◽  
I. Munro ◽  
...  
Keyword(s):  
Synchrotron Radiation ◽  
Ion Pair ◽  
Time Resolved ◽  
Pair State
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