Conservative Treatment Modalities of Choroidal Melanomas

1985 ◽  
pp. 27-54 ◽  
Author(s):  
J. A. Oosterhuis
2004 ◽  
Vol 56 (1) ◽  
pp. 20-22
Author(s):  
Urvashi Razdan ◽  
R. M. Raizada ◽  
V. N. Chaturvedi

2017 ◽  
Vol 41 (6) ◽  
pp. 472-477
Author(s):  
Mounabati Mohapatra ◽  
Ashok Kumar Jena ◽  
Arun Kumar Dandapat ◽  
Sombir Singh

Massive osteolysis in a 7-year old child is a rare condition. The etiology of massive osteolysis is unknown and it results in the progressive destruction of bony structures. There is no standard therapy available in the literature. Conservative treatment is often used for its management. Radiotherapy is considered as an accepted form of treatment with greater chance of success when it is used in the early course of disease. There are few case reports in the literature in which radiotherapy has been used for the treatment. This article highlights the literature update on various treatment modalities and a case managed by radiation therapy.


ISRN Oncology ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Fatih Selçukbiricik ◽  
Deniz Tural ◽  
Olgun Elicin ◽  
Selin Berk ◽  
Mustafa Özgüroğlu ◽  
...  

Objectives. The aim of this study was to evaluate clinical characteristics, prognostic factors, survival rates, and treatment modalities in patients with primary gastric lymphoma (PGL). Methods. We retrospectively reviewed and analyzed data from patients treated for PGL in our clinic from 1998 through 2010. Staging was performed using the Lugano Staging System. Overall and disease-free survival (OS and DFS) were calculated from the date of diagnosis. Results. We identified 79 patients. Thirty-seven patients (47%) were male. The median age at presentation was 57 (18–85) years. The median follow-up time was 41 (9–52) months. Thirty patients (38%) underwent surgery, 74 (92%) received chemotherapy, and 18 (23%) received radiotherapy. The five-year OS and DFS rates were 91.2% and 83.9%, respectively, in patients with stage I/II or IIE disease and 70.6% and 65.5%, respectively, in patients with stage IV disease ( for both rates). Treatment modality (surgical or conservative) had no impact on OS or DFS in early stages. In a multivariate analysis, poor performance status, advanced stage, and high LDH levels were significant bad prognostic factors for DFS, while advanced stage, poor performance status, and age > 60 years were significant bad prognostic factors for OS. Conclusion. Surgery provides no advantage for survival over conservative treatment; thus, conservative treatment modalities should be preferred initially at early stages of PGL.


2010 ◽  
Vol 38 (2) ◽  
pp. 133-145 ◽  
Author(s):  
Michael J. Langworthy ◽  
Amira Saad ◽  
Nadia M. Langworthy

2020 ◽  
Author(s):  
Mingrui Xia ◽  
Jun Liu ◽  
Yang Hong ◽  
Lizhe An ◽  
Liulin Xiong ◽  
...  

Abstract Objective To identify possible clinical indicators to guide the choice of treatment in patients with renal abscess. Methods According to different treatment methods, 38 patients initially diagnosed with renal abscess and received no prior treatment (antipyretics excepted) in our institution from April 2006 to November 2019 were divided into conservative treatment group and invasive treatment group, with the clinical data of all the cases being analyzed retrospectively. Results In the conservative treatment group, 19 patients got success and 1 failed in initial treatment, while in the invasive treatment group, 15 patients got success and 3 failed. Of the 4 patients who failed the initial treatment, 3 had a renal abscess between 3 cm and 5 cm, and 1 failed due to long-term use of bone marrow suppressive drugs. In univariate analysis, there were significant differences between the two groups in the following factors: diabetes mellitus, body temperature ≥ 38.5℃, PLT, RDW, BUN, PLR, AG, WBC in urine, size of abscess. In logistic regression analysis, diabetes mellitus, RDW and size of renal abscess were retained. The cut-off of RDW and size of renal abscess were 14.07% and 3.9 cm respectively. Conclusions Size of renal abscess is still the most important factor that determining treatment modalities. Other than size, high RDW and the comorbidity of diabetes mellitus may also be used as the possible clinical indicators for the determination of invasive treatment, especially in patients with renal abscess between 3 ~ 5 cm in size.


2019 ◽  
Vol 5 (6) ◽  
pp. 396-401 ◽  
Author(s):  
Alice Leblanc ◽  
Livia Lumbroso-Le Rouic ◽  
Laurence Desjardins ◽  
Rémi Dendale ◽  
Nathalie Cassoux

Objectives: Iris melanomas represent 2–3% of uveal melanomas; the diffuse variant accounts for approximately 10% of all iris melanomas. Different treatment modalities for diffuse iris melanomas (DIM) have been proposed depending on the local status as well as the age and general condition of the patient. Methods: This study is a single-centre retrospective case series describing the diagnosis, treatments and outcomes of DIM. Treatment consisted of enucleation or proton beam therapy (PT) of the whole anterior segment. Patients who were treated with PT benefitted from limbal stem cell preservation before irradiation. Results: Between 1996 and 2016, a total of 14 patients with DIM presented to our institution and were included in the database. The global survival was 86%. The median follow-up was 4.6 years (range 4 months to 15 years). Only 1 patient (7%) developed metastatic disease of the DIM (gastric location). No patient developed liver metastasis. Seven patients were treated by enucleation and 7 by PT after limbal stem cell preservation. After a conservative attempt, local tumour recurrence occurred in 2 patients at 2 years, requiring enucleation. The cornea was clear after irradiation in all patients. Cataract (n = 6) and glaucoma (n = 4) were the main complications after irradiation. Conclusions: DIM is a very rare tumour. The global survival is excellent. Conservative treatment with PT is an efficient alternative to enucleation and allows good local tumour control. Cataract and glaucoma are the main radiation-related complications, but the corneal status was excellent due to the stem cell harvest prior to radiotherapy.


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