Intracellular, Intranuclear, and Subchromosomal Localization of Anthracycline Antibiotics

1982 ◽  
pp. 103-116 ◽  
Author(s):  
M. Robert-Nicoud ◽  
N. Bachur
Keyword(s):  
Anthracycline Antibiotics

Xanthocyclines: 5-oxaanthracyclines (7,8,9,10-tetrahydrobenzo[b]xanthen-12-one)

1982 ◽  
Vol 60 (15) ◽  
pp. 1996-2001 ◽  
Author(s):  
James L. Charlton ◽  
Vilayat A. Sayeed ◽  
Gerald N. Lypka
Keyword(s):  
Antitumor Agents ◽  
Clinical Use ◽  
Cyclization Reactions ◽  
Anthracycline Antibiotics

The anthracycline antibiotics daunorubicin and adriamycin are potent antitumor agents. It has recently been suggested that 5-oxaanthracycline analogs of these compounds might show reduced cardiotoxicity, a property that limits the clinical use of the anthracyclines. In this paper we describe the condensation–cyclization reactions of 2-methylchromone-3-carboxylate with cyclohexanones, a reaction that leads ultimately to the xanthocycline skeleton.

scholarly journals Enhanced Efficiency of the Removal of Cytostatic Anthracycline Drugs Using Immobilized Mycelium of Bjerkandera adusta CCBAS 930

Molecules ◽  
2021 ◽  
Vol 26 (22) ◽  
pp. 6842
Author(s):  
Kamila Rybczyńska-Tkaczyk
Keyword(s):  
Superoxide Dismutase ◽  
Free Radicals ◽  
Phenolic Compounds ◽  
Glucose Oxidase ◽  
Biological Treatment ◽  
Lepidium Sativum ◽  
Bjerkandera Adusta ◽  
Anthracycline Antibiotics ◽  
Lepidium Sativum L

The aim of this study was to evaluate the bioremoval of anthracycline antibiotics (daunomycin-DNR, doxorubicin–DOX, and mitoxantrone-MTX) by immobilized mycelium of B. adusta CCBAS 930. The activity of oxidoreductases: versatile peroxidases (VP), superoxide dismutase (SOD), catalase (CAT), and glucose oxidase (GOX), and the levels of phenolic compounds (PhC) and free radicals (SOR) were determined during the biotransformation of anthracyclines by B. adusta strain CCBAS 930. Moreover, the phytotoxicity (Lepidium sativum L.), biotoxicity (MARA assay), and genotoxicity of anthracyclines were evaluated after biological treatment. After 120 h, more than 90% of anthracyclines were removed by the immobilized mycelium of B. adusta CCBAS 930. The effective biotransformation of anthracyclines was correlated with detoxification and reduced genotoxicity.

scholarly journals Chemical modification of anthracycline antibiotics. V Synthesis of 2-hydroxyaclacinomycin A by chemical glycosidation.

1983 ◽  
Vol 36 (5) ◽  
pp. 601-603 ◽  
Author(s):  
HIROSHI TANAKA ◽  
TAKEO YOSHIOKA ◽  
AKIHIRO YOSHIMOTO ◽  
YASUTAKA SHIMAUCHI ◽  
TOMOYUKI ISHIKURA ◽  
...  
Keyword(s):  
Chemical Modification ◽  
Anthracycline Antibiotics

scholarly journals Production of new anthracycline antibiotics 1-hydroxyoxaunomycin and 6-deoxyoxaunomycine by limited biosynthetic conversion using a daunorubicin-negative mutant.

1992 ◽  
Vol 45 (10) ◽  
pp. 1609-1617 ◽  
Author(s):  
AKIHIRO YOSHIMOTO ◽  
OSAMU JOHDO ◽  
HIROSHI TONE ◽  
ROKUROU OKAMOTO ◽  
HIROSHI NAGANAWA ◽  
...  
Keyword(s):  
Anthracycline Antibiotics ◽  
Negative Mutant

Approaches to the regiospecific synthesis of Anthracycline antibiotics

Tetrahedron ◽  
1982 ◽  
Vol 38 (20) ◽  
pp. 3079-3084 ◽  
Author(s):  
Jack E. Baldwin ◽  
Algis J. Rajeckas
Keyword(s):  
Anthracycline Antibiotics

scholarly journals Isolation of new anthracycline antibiotics, A447 C and D.

1987 ◽  
Vol 40 (1) ◽  
pp. 116-121 ◽  
Author(s):  
AKIHIRO SHIMOSAKA ◽  
YOICHI HAYAKAWA ◽  
MASAYA NAKAGAWA ◽  
KAZUO FURIHATA ◽  
HARUO SETO ◽  
...  
Keyword(s):  
Anthracycline Antibiotics
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