chemical investigation
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2022 ◽  
Vol 195 ◽  
pp. 113060
Author(s):  
Anthi Vlassi ◽  
Aikaterini Koutsaviti ◽  
Theophanis Constantinidis ◽  
Efstathia Ioannou ◽  
Olga Tzakou

Author(s):  
María Miguel-Gordo ◽  
Maggie Reddy ◽  
Pilar Sanchez ◽  
Jordan Buckley ◽  
Thomas Mackenzie ◽  
...  

An abundant sponge of the order Bubarida was selected for further chemical investigation following biological and chemical screening of sponges collected from Futuna Islands in the Indo-Pacific. Ten new nitrogenous...


2021 ◽  
pp. 114959
Author(s):  
Yang Gao ◽  
Bobo Wang ◽  
Jing Yang ◽  
Rui Zhang ◽  
Nana Liu ◽  
...  

2021 ◽  
Author(s):  
A Charalabidis ◽  
D Abatis ◽  
A Cheilari ◽  
E Gikas ◽  
N Proxenia ◽  
...  

2021 ◽  
pp. 107136
Author(s):  
Cristina Riccucci ◽  
Gabriel Maria Ingo ◽  
Marianna Pascucci ◽  
Maria Paola Staccioli ◽  
Maria Isabella Pierigè ◽  
...  

Molecules ◽  
2021 ◽  
Vol 26 (23) ◽  
pp. 7144
Author(s):  
Ahmed H. Elbanna ◽  
Zeinab G. Khalil ◽  
Robert J. Capon

The ethyl acetate extract of an ISP-2 agar cultivation of the wasp nest-associated fungus Penicillium sp. CMB-MD14 exhibited promising antibacterial activity against vancomycin-resistant enterococci (VRE), with a bioassay guided chemical investigation yielding the new meroterpene, oxandrastin A (1), the first andrastin-like metabolite with an extra oxygenation at C-2. A culture media optimisation strategy informed a scaled-up rice cultivation that yielded 1, together with three new oxandrastins B–D (2–4), two known andrastins C (5) and F (6), and a new meroterpene of the austalide family, isoaustalide F (7). Structures of 1–7 were assigned based on detailed spectroscopic analysis and chemical interconversion. A GNPS molecular networking analysis of the rice cultivation extract detected the known austalides B (8), H (9), and H acid (10), tentatively identified based on molecular formulae and co-clustering with 7. That the anti-VRE properties of the CMB-MD14 extract were exclusively attributed to 1 (IC50 6.0 µM, MIC99 13.9 µM), highlights the importance of the 2-OAc and 3-OAc moieties to the oxandrastin anti-VRE pharmacophore.


2021 ◽  
Vol 121 ◽  
pp. 111616
Author(s):  
Vadivel Siva ◽  
Anbazhagan Murugan ◽  
Abdul samad Shameem ◽  
Shunmuganarayanan Athimoolam ◽  
Sultan Asath Bahadur

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