Secretion of plasminogen activator by mouse peritoneal macrophages elicited by injection of a suspension of killed streptococci

1980 ◽  
pp. 847-849
Author(s):  
Geneviève Lemaire ◽  
J.-C. Drapier ◽  
J.-F. Petit
Keyword(s):  
Plasminogen Activator ◽  
Peritoneal Macrophages ◽  
Mouse Peritoneal Macrophages

Infiltration and survival: the behaviour of normal, invasive cells implanted to the developing chick wing

1979 ◽  
Vol 40 (1) ◽  
pp. 257-270
Author(s):  
C. Tickle ◽  
A. Crawley
Keyword(s):  
Endothelial Cells ◽  
Plasminogen Activator ◽  
Blood Cells ◽  
Peritoneal Macrophages ◽  
Neutrophil Granulocytes ◽  
Activated Macrophages ◽  
Wing Bud ◽  
Mesenchyme Cells ◽  
Mouse Peritoneal Macrophages ◽  
Mouse Lymphocytes

The invasiveness of mouse lymphocytes and thymocytes, rabbit peritoneal neutrophil granulocytes (PMNs), mouse peritoneal macrophages (both activated and non-activated) and pig endothelial cells was assayed by implanting these cells to the chick wing bud. Cells of each type moved into the wing mesenchyme, although activated macrophages invaded poorly. PMNs were the most invasive cells and had moved well into the limb after only a few hours. PMNs, lymphocytes and thymocytes were ingested by wing mesenchyme cells. Endothelial cells, however, ingested chick blood cells. The implanted cells showed differences in ability to survive in the limb: PMNs disappeared rapidly, lymphocytes and thymocytes sometimes persisted for 24 h, while grafts of macrophages and endothelial cells were present at 24 h. Mechanisms which might be involved in the invasiveness of these cells, and also in their different abilities to survive in the chick wing, are discussed with particular reference to the production of plasminogen activator.

Regulation of plasminogen activator secretion in mouse peritoneal macrophages

Biochimie ◽  
1979 ◽  
Vol 61 (4) ◽  
pp. 463-471 ◽  
Author(s):  
Jean Claude Drapier ◽  
Jean Pierre Tenu ◽  
Geneviève Lemaire ◽  
Jean François Petit
Keyword(s):  
Plasminogen Activator ◽  
Peritoneal Macrophages ◽  
Mouse Peritoneal Macrophages

scholarly journals Trypanosoma cruzi: the immunological induction of macrophage plasminogen activator requires thymus-derived lymphocytes.

1977 ◽  
Vol 146 (1) ◽  
pp. 172-183 ◽  
Author(s):  
N Nogueira ◽  
S Gordon ◽  
Z Cohn
Keyword(s):  
Trypanosoma Cruzi ◽  
Spleen Cell ◽  
Plasminogen Activator ◽  
Peritoneal Macrophages ◽  
Enzyme Secretion ◽  
Cell Populations ◽  
Spleen Cells ◽  
Trypanocidal Activity ◽  
Mouse Peritoneal Macrophages

In this article we describe methods in which unstimulated mouse peritoneal macrophages were induced to secrete high livels of plasminogen activator under in vitro conditions. The exposure of sensitized peritoneal or spleen cell populations from Trypanosoma cruzi-infected animals to either viable or heat-killed trypanosomes lead to the release of an inducing factor(s). Maximal levels of plasminogen activator secretion are achieved by the incubation of such factors (s) with unstimulated macrophages for 48 h. A significant increase in enzyme secretion was already observed after a 24 h incubation. The production of the inducing factor(s) by sensitized cells was immunologically specific and unrelated antigens did not stimulate the production of the factor(s) by sensitized peritoneal or spleen cell populations. The inducing factor(s) was produced by nylon-wool-fractionated spleen and peritoneal cells which had been depleted of marcrophages. Pretreatment of sensitized spleen cells with anti-theta serum and C abolished the production of the activating factor(s). The active supernatant fluids were able to induce secretion of macrophage plasminogen activator across H-2 barriers. Attempts to induce trypanocidal activity in unstimulated macrophages have not been successful.

scholarly journals A macrophage tumor cell line and plasminogen activator. A potential model system for macrophage regulation of enzyme production.

1978 ◽  
Vol 148 (3) ◽  
pp. 811-816 ◽  
Author(s):  
J A Hamilton ◽  
P Ralph ◽  
M A Moore
Keyword(s):  
Cell Line ◽  
Plasminogen Activator ◽  
Tumor Cell Line ◽  
Peritoneal Macrophages ◽  
Enzyme Synthesis ◽  
Suitable Model ◽  
Macrophage Cell ◽  
Low Concentrations ◽  
Regulation Of Enzyme Synthesis ◽  
Mouse Peritoneal Macrophages

The macrophage cell line, RAW264.10, synthesizes and secretes plasminogen activator. Production of this enzyme is inhibited by low concentrations of glucocorticoids and increased by phorbol myristate acetate. It is proposed that this line could be a suitable model for the regulation of enzyme synthesis by mouse peritoneal macrophages.

Immunostimulatory Effects of Purple Bamboo Salts Composed with Rubus coreanus in Raw264.7 Cells and Mouse Peritoneal Macrophages

2017 ◽  
Vol 46 (3) ◽  
pp. 306-313
Author(s):  
Heejeon Park ◽  
Sokho Kim ◽  
Sohee Jeong ◽  
Heeran Park ◽  
Jin-Hyung Kim ◽  
...  
Keyword(s):  
Peritoneal Macrophages ◽  
Raw264.7 Cells ◽  
Rubus Coreanus ◽  
Mouse Peritoneal Macrophages
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