In vitro methods for assessing anti-inflammatory drug activity (Abstract)

1977 ◽  
pp. 387-389
Author(s):  
A. Tursi ◽  
M. P. Loria ◽  
G. Specchia ◽  
L. Bonomo
Keyword(s):  
Inflammatory Drug ◽  
Drug Activity ◽  
In Vitro Methods ◽  
Anti Inflammatory

Rare-earth complexes with anti-inflammatory drug sulindac: synthesis, characterization, spectroscopic and in vitro biological studies

2021 ◽  
pp. 120516
Author(s):  
Renan Barrach Guerra ◽  
Diogo Alves Gálico ◽  
Thais Fernanda de Campos Fraga-Silva ◽  
Julia Aguiar ◽  
James Venturini ◽  
...  
Keyword(s):  
Rare Earth ◽  
Rare Earth Complexes ◽  
Inflammatory Drug ◽  
Biological Studies ◽  
Anti Inflammatory

Microwave-assisted synthesis and in vitro stability of N-benzylamide non-steroidal anti-inflammatory drug conjugates for CNS delivery

2019 ◽  
Vol 29 (12) ◽  
pp. 1487-1491 ◽  
Author(s):  
Brandon D. Eden ◽  
Andrew J. Rice ◽  
Troy D. Lovett ◽  
Olivia M. Toner ◽  
Evan P. Geissler ◽  
...  
Keyword(s):  
Microwave Assisted Synthesis ◽  
Inflammatory Drug ◽  
Microwave Assisted ◽  
Drug Conjugates ◽  
Anti Inflammatory ◽  
In Vitro Stability ◽  
Cns Delivery

Development, in-vitro and in-vivo characterization of gelatin nanoparticles for delivery of an anti-inflammatory drug

2016 ◽  
Vol 36 ◽  
pp. 55-61 ◽  
Author(s):  
Alok Mahor ◽  
Sunil Kumar Prajapati ◽  
Amita Verma ◽  
Rishikesh Gupta ◽  
Thakur Raghu Raj Singh ◽  
...  
Keyword(s):  
Gelatin Nanoparticles ◽  
Inflammatory Drug ◽  
Anti Inflammatory ◽  
Development In Vitro ◽  
In Vivo Characterization

scholarly journals IN VITRO PHARMACOLOGICAL SCREENING METHODS FOR ANTI-INFLAMMATORY AGENTS

2018 ◽  
Vol 11 ◽  
Author(s):  
Jayakumari S ◽  
Jijith Us
Keyword(s):  
Leukocyte Adhesion ◽  
Induced Response ◽  
Screening Methods ◽  
Adhesion Assay ◽  
Polymorphonuclear Cells ◽  
In Vitro Methods ◽  
Anti Inflammatory ◽  
Pharmacological Screening ◽  
New Compounds

Context: The development of in vitro methods is important in drug discovery process due to the restriction of animal use in the pharmacological screening process.Objective: The objective of the review was to understand the in vitro pharmacological screening methods for anti-inflammatory agents.Methods: The present review details various in vitro methods available for the screening of activity of therapeutic agents against inflammation.Results: Inhibition and measurement of nitric oxide production, mast cell degranulation, leukocyte adhesion assay, platelet-neutrophil adhesion assay, lipopolysaccharide-induced response assay, N-formyl-methionyl-leucyl-phenylalanine-induced O2 generation by polymorphonuclear cells, and cyclooxygenase assays are discussed in this review.Conclusions: These methods help to understand the real mechanism of inflammation and mediators involved in this process and help toidentify new compounds possessing the anti-inflammatory activity.

Tolmetin and G-6-PD Erythrocyte Deficiency: Research in Vitro

1979 ◽  
Vol 7 (5) ◽  
pp. 351-353 ◽  
Author(s):  
G Passiu ◽  
M G Piras ◽  
G Perpignano ◽  
G Ibba ◽  
U Carcassi
Keyword(s):  
The Other ◽  
Inflammatory Drug ◽  
Other Hand ◽  
Anti Inflammatory

In thirty-two patients, divided into four groups: normal, G-6-PD deficient, β-thalaxemic heterozygote and carriers of both anomalies, the variations in erythrocyte GSH were studied after incubation with APH and a nonsteroidal anti-inflammatory drug: tolmetin sodium. The results obtained show a considerable fall in GSH after incubation with APH above all in the G-6-PD deficient patients and in the carriers of both anomalies. On the other hand, after incubation with the drug under examination there were no significant variations in the erythrocyte GSH.

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