Treatment Resistance in Obsessive-Compulsive Disorder

2018 ◽  
pp. 165-177 ◽  
Author(s):  
Rachel Middleton ◽  
Michael G. Wheaton ◽  
Reilly Kayser ◽  
H. Blair Simpson
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Treatment Resistance ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

Prediction of treatment resistance in obsessive compulsive disorder patients based on EEG complexity as a biomarker

2020 ◽  
Vol 131 (3) ◽  
pp. 716-724
Author(s):  
Tuğçe Ballı Altuğlu ◽  
Barış Metin ◽  
Emine Elif Tülay ◽  
Oğuz Tan ◽  
Gökben Hızlı Sayar ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Treatment Resistance ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

scholarly journals Treatment of Severe, Treatment-Refractory Obsessive-Compulsive Disorder: A Study of Inpatient and Community Treatment

CNS Spectrums ◽  
2008 ◽  
Vol 13 (12) ◽  
pp. 1056-1065 ◽  
Author(s):  
Mark J. Boschen ◽  
Lynne M. Drummond ◽  
Anusha Pillay
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Behavioral Treatment ◽  
Treatment Resistance ◽  
Outpatient Setting ◽  
Community Treatment ◽  
Inpatient Setting ◽  
Outcome Study ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Complicating Factors

ABSTRACTIntroduction:This research reports on a prospective outcome study of two cohorts of patients with severe, chronic, resistant obsessive-compulsive disorder (OCD).Methods:One cohort consisted of a total of 52 patients treated in an inpatient setting, while the second group comprised 65 patients treated in a community-outpatient setting. Treatment consistent primarily of intensive graded exposure and self-imposed response prevention augmented with cognitive restructuring.Results:The groups demonstrated significant improvement over the course of treatment. In the inpatient and community groups, there was significant improvement over the first 12 weeks of treatment, and further improvement between 12 and 24 weeks.Conclusion:These results suggest that even for patients who have demonstrated treatment-resistance, there may be benefit in intensive behavioral treatment of OCD. In addition it was found that even for those patients with the most profound refractory OCD and complicating factors inpatient stays of up to 24 weeks were effective in reducing symptoms.

scholarly journals Dietary quality and nutrient intake in adults with obsessive–compulsive disorder

BJPsych Open ◽  
2021 ◽  
Vol 7 (6) ◽  
Author(s):  
Thomas P. Nguyen ◽  
Lachlan Cribb ◽  
Chee H. Ng ◽  
Gerard J. Byrne ◽  
David Castle ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Nutrient Intake ◽  
Treatment Resistance ◽  
Healthy Eating Index ◽  
Dietary Guidelines ◽  
Dietary Quality ◽  
Linear Regression Models ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
The Relationship

Background Many mental disorders, including depression, bipolar disorder and schizophrenia, are associated with poor dietary quality and nutrient intake. There is, however, a deficit of research looking at the relationship between obsessive–compulsive disorder (OCD) severity, nutrient intake and dietary quality. Aims This study aims to explore the relationship between OCD severity, nutrient intake and dietary quality. Method A post hoc regression analysis was conducted with data combined from two separate clinical trials that included 85 adults with diagnosed OCD, using the Structured Clinical Interview for DSM-5. Nutrient intakes were calculated from the Dietary Questionnaire for Epidemiological Studies version 3.2, and dietary quality was scored with the Healthy Eating Index for Australian Adults – 2013. Results Nutrient intake in the sample largely aligned with Australian dietary guidelines. Linear regression models adjusted for gender, age and total energy intake showed no significant associations between OCD severity, nutrient intake and dietary quality (all P > 0.05). However, OCD severity was inversely associated with caffeine (β = −15.50, 95% CI −28.88 to −2.11, P = 0.024) and magnesium (β = −6.63, 95% CI −12.72 to −0.53, P = 0.034) intake after adjusting for OCD treatment resistance. Conclusions This study showed OCD severity had little effect on nutrient intake and dietary quality. Dietary quality scores were higher than prior studies with healthy samples, but limitations must be noted regarding comparability. Future studies employing larger sample sizes, control groups and more accurate dietary intake measures will further elucidate the relationship between nutrient intake and dietary quality in patients with OCD.

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