Overview of Protein-Protein Interactions and Small-Molecule Inhibitors Under Clinical Development

2018 ◽  
pp. 3-28
Author(s):  
Guoqiang Dong ◽  
Chunquan Sheng
Keyword(s):  
Small Molecule ◽  
Protein Interactions ◽  
Small Molecule Inhibitors ◽  
Clinical Development ◽  
Protein Protein Interactions

Elucidating Protein-protein Interactions Through Computational Approaches and Designing Small Molecule Inhibitors Against them for Various Diseases

2018 ◽  
Vol 18 (20) ◽  
pp. 1719-1736 ◽  
Author(s):  
Sharanya Sarkar ◽  
Khushboo Gulati ◽  
Manikyaprabhu Kairamkonda ◽  
Amit Mishra ◽  
Krishna Mohan Poluri
Keyword(s):  
Small Molecule ◽  
Protein Interactions ◽  
Small Molecule Inhibitors ◽  
Computational Techniques ◽  
Protein Protein Interactions ◽  
Computational Tools ◽  
Computational Approaches ◽  
Protein Protein Interaction ◽  
Wide Range ◽  
Therapeutic Measures

Background: To carry out wide range of cellular functionalities, proteins often associate with one or more proteins in a phenomenon known as Protein-Protein Interaction (PPI). Experimental and computational approaches were applied on PPIs in order to determine the interacting partners, and also to understand how an abnormality in such interactions can become the principle cause of a disease. Objective: This review aims to elucidate the case studies where PPIs involved in various human diseases have been proven or validated with computational techniques, and also to elucidate how small molecule inhibitors of PPIs have been designed computationally to act as effective therapeutic measures against certain diseases. Results: Computational techniques to predict PPIs are emerging rapidly in the modern day. They not only help in predicting new PPIs, but also generate outputs that substantiate the experimentally determined results. Moreover, computation has aided in the designing of novel inhibitor molecules disrupting the PPIs. Some of them are already being tested in the clinical trials. Conclusion: This review delineated the classification of computational tools that are essential to investigate PPIs. Furthermore, the review shed light on how indispensable computational tools have become in the field of medicine to analyze the interaction networks and to design novel inhibitors efficiently against dreadful diseases in a shorter time span.

Targeting Disease with Small Molecule Inhibitors of Protein-Protein Interactions

2010 ◽  
pp. 215-238
Author(s):  
Fedor Forafonov ◽  
Elena Miranda ◽  
Ida Karin Nordgren ◽  
Ali Tavassoli
Keyword(s):  
Small Molecule ◽  
Protein Interactions ◽  
Small Molecule Inhibitors ◽  
Protein Protein Interactions

scholarly journals Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality

2014 ◽  
Vol 21 (9) ◽  
pp. 1102-1114 ◽  
Author(s):  
Michelle R. Arkin ◽  
Yinyan Tang ◽  
James A. Wells
Keyword(s):  
Small Molecule ◽  
Protein Interactions ◽  
Small Molecule Inhibitors ◽  
Protein Protein Interactions

Rational Design of Selective Small-Molecule Inhibitors for β-Catenin/B-Cell Lymphoma 9 Protein–Protein Interactions

2015 ◽  
Vol 137 (38) ◽  
pp. 12249-12260 ◽  
Author(s):  
Logan R. Hoggard ◽  
Yongqiang Zhang ◽  
Min Zhang ◽  
Vanja Panic ◽  
John A. Wisniewski ◽  
...  
Keyword(s):  
B Cell ◽  
Small Molecule ◽  
Protein Interactions ◽  
Rational Design ◽  
Small Molecule Inhibitors ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Protein Protein Interactions ◽  
Catenin B

scholarly journals Correction: State-of-the-art strategies for targeting protein–protein interactions by small-molecule inhibitors

2015 ◽  
Vol 44 (22) ◽  
pp. 8375-8375 ◽  
Author(s):  
Chunquan Sheng ◽  
Guoqiang Dong ◽  
Zhenyuan Miao ◽  
Wannian Zhang ◽  
Wei Wang
Keyword(s):  
Small Molecule ◽  
Protein Interactions ◽  
Small Molecule Inhibitors ◽  
State Of The Art ◽  
Protein Protein Interactions

Correction for ‘State-of-the-art strategies for targeting protein–protein interactions by small-molecule inhibitors’ by Chunquan Sheng et al., Chem. Soc. Rev., 2015, DOI: 10.1039/c5cs00252d.

scholarly journals Small-Molecule Inhibitors That Target Protein-Protein Interactions in the RAD51 Family of Recombinases

ChemMedChem ◽  
2014 ◽  
Vol 10 (2) ◽  
pp. 296-303 ◽  
Author(s):  
Duncan E. Scott ◽  
Anthony G. Coyne ◽  
Ashok Venkitaraman ◽  
Tom L. Blundell ◽  
Chris Abell ◽  
...  
Keyword(s):  
Small Molecule ◽  
Protein Interactions ◽  
Small Molecule Inhibitors ◽  
Target Protein ◽  
Protein Protein Interactions

Inhibition of bromodomain-mediated protein–protein interactions as a novel therapeutic strategy

MedChemComm ◽  
2012 ◽  
Vol 3 (2) ◽  
pp. 123-134 ◽  
Author(s):  
Silviya D. Furdas ◽  
Luca Carlino ◽  
Wolfgang Sippl ◽  
Manfred Jung
Keyword(s):  
Small Molecule ◽  
Protein Interactions ◽  
Therapeutic Strategy ◽  
Small Molecule Inhibitors ◽  
Protein Protein Interactions ◽  
Therapeutic Approaches ◽  
Novel Therapeutic

Small molecule inhibitors of acetyl lysine–bromodomain interactions emerge as novel epigenetic tools with potential for therapeutic approaches.

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