Efficient Test for Nonlinear Dependence of Two Continuous Variables

Author(s):  
McKenzie Ritter ◽  
Yi Li ◽  
Yi Wang ◽  
Yin Yao ◽  
Li Jin
2015 ◽  
Vol 16 (1) ◽  
Author(s):  
Yi Wang ◽  
Yi Li ◽  
Hongbao Cao ◽  
Momiao Xiong ◽  
Yin Yao Shugart ◽  
...  

Author(s):  
I. G. Shubin ◽  
A. A. Kurkin

During manufacturing nuts of increased height, a problem of obtaining correct cylindrical form of the hole for thread and overall geometrical parameters arises. To solve the problem it is necessary to know regularity of the blank forming process. Results of the study of a technological process of high hexahedral nuts forming presented. The nuts were M18 of 22 mm height, M16 of 19 mm height and M12 of normal height 10 mm according to GOST 5915–70, accuracy class B, steel grade 10 according to GOST 10702–78. The volumetric stamping was accomplished at the five-position automatic presses of АА1822 type. It was determined, that unevenness of the metal flow in the process of plastic deformation of blanks of increased height nuts was caused by different stress conditions by their sections. To simulate the mode of deformation, the program complex QForm-3D was chosen. The complex ensured to forecast with necessary accuracy the metal flow in a blank, as well as to define the deformation force and arising stress in the working instrument. The simulation showed the presence of regularity between preliminary formed buffle and deviation of dimensions and form of a blank wall after its finishing piercing, which can be expressed by a nonlinear dependence. The limit values of the relative height of the buffle С/D = 0.56–0.588 defined, exceeding which will result in rejection of the finished product. Accounting the limit values of the relative height of the buffle will enable to correct a mode of technological operations and technological instruments at stamping of high hexahedral nuts.


2019 ◽  
Author(s):  
Xiaohui Wang ◽  
Zhaoxi Sun

<p>Correct calculation of the variation of free energy upon base flipping is crucial in understanding the dynamics of DNA systems. The free energy landscape along the flipping pathway gives the thermodynamic stability and the flexibility of base-paired states. Although numerous free energy simulations are performed in the base flipping cases, no theoretically rigorous nonequilibrium techniques are devised and employed to investigate the thermodynamics of base flipping. In the current work, we report a general nonequilibrium stratification scheme for efficient calculation of the free energy landscape of base flipping in DNA duplex. We carefully monitor the convergence behavior of the equilibrium sampling based free energy simulation and the nonequilibrium stratification and determine the empirical length of time blocks required for converged sampling. Comparison between the performances of equilibrium umbrella sampling and nonequilibrium stratification is given. The results show that nonequilibrium free energy simulation is able to give similar accuracy and efficiency compared with the equilibrium enhanced sampling technique in the base flipping cases. We further test a convergence criterion we previously proposed and it comes out that the convergence behavior determined by this criterion agrees with those given by the time-invariant behavior of PMF and the nonlinear dependence of standard deviation on the sample size. </p>


2020 ◽  
Vol 132 (3) ◽  
pp. 692-699 ◽  
Author(s):  
Sarah K. Bick ◽  
Marjan S. Dolatshahi ◽  
Benjamin L. Grannan ◽  
Andrew J. Cole ◽  
Daniel B. Hoch ◽  
...  

OBJECTIVEForamen ovale electrodes (FOEs) are a minimally invasive method to localize mesial temporal seizures in cases in which noninvasive methods are inconclusive. The objective of this study was to identify factors predicting the ability of FOEs to yield a diagnosis in order to determine optimal candidates for this procedure.METHODSAll cases of diagnostic investigations performed with FOEs at the authors’ institution between 2005 and 2017 were reviewed. FOE investigation was defined as diagnostic if it led to a treatment decision. Demographic and clinical variables for diagnostic and nondiagnostic investigations were compared using a Wilcoxon rank-sum test for continuous variables and Fisher’s exact test for categorical variables.RESULTSNinety-three patients underwent investigations performed with FOEs during the study period and were included in the study. FOE investigation was diagnostic in 75.3% of cases. Of patients who underwent anterior temporal lobectomy following diagnostic FOE evaluation, 75.9% were Engel class I at last follow-up (average 40.1 months). When the diagnostic and nondiagnostic FOE groups were compared, patients who had diagnostic investigations were more likely to be male (57.1% male vs 26.1% in the nondiagnostic group, p = 0.015). They were also more likely to have temporal lesions on preoperative MRI (p = 0.018).CONCLUSIONSFOEs are a useful, minimally invasive diagnostic modality resulting in a treatment decision in 75% of cases. Male patients and patients with temporal lesions on MRI may be most likely to benefit from FOE investigation.


Sign in / Sign up

Export Citation Format

Share Document