Plasticity of Epidermal Stem Cells: The Future of Stem Cell-Based Therapeutics to Improve Cutaneous Wound Healing

2019 ◽  
pp. 357-389
Author(s):  
Xiaoyan Sun ◽  
Hua Qin ◽  
Siming Yang ◽  
Xiaobing Fu
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Stem Cell ◽  
Cutaneous Wound Healing ◽  
Epidermal Stem Cells ◽  
Cutaneous Wound ◽  
The Future

scholarly journals Advances of Stem Cell Therapeutics in Cutaneous Wound Healing and Regeneration

2017 ◽  
Vol 2017 ◽  
pp. 1-14 ◽  
Author(s):  
Suman Kanji ◽  
Hiranmoy Das
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Stem Cell ◽  
Wound Repair ◽  
Chronic Wounds ◽  
Healing Process ◽  
Treatment Modalities ◽  
Wound Healing Process ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound

Cutaneous wound healing is a complex multiple phase process, which overlaps each other, where several growth factors, cytokines, chemokines, and various cells interact in a well-orchestrated manner. However, an imbalance in any of these phases and factors may lead to disruption in harmony of normal wound healing process, resulting in transformation towards chronic nonhealing wounds and abnormal scar formation. Although various therapeutic interventions are available to treat chronic wounds, current wound-care has met with limited success. Progenitor stem cells possess potential therapeutic ability to overcome limitations of the present treatments as it offers accelerated wound repair with tissue regeneration. A substantial number of stem cell therapies for cutaneous wounds are currently under development as a result of encouraging preliminary findings in both preclinical and clinical studies. However, the mechanisms by which these stem cells contribute to the healing process have yet to be elucidated. In this review, we emphasize on the major treatment modalities currently available for the treatment of the wound, role of various interstitial stem cells and exogenous adult stem cells in cutaneous wound healing, and possible mechanisms involved in the healing process.

Engineered Human Adipose Stem-Cell-Derived Exosomes Loaded with miR-21-5p to Promote Diabetic Cutaneous Wound Healing

2020 ◽  
Vol 17 (5) ◽  
pp. 1723-1733 ◽  
Author(s):  
Qijun Lv ◽  
Junfeng Deng ◽  
You Chen ◽  
Yizhen Wang ◽  
Bo Liu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Cutaneous Wound Healing ◽  
Adipose Stem Cell ◽  
Cutaneous Wound ◽  
Human Adipose Stem Cell
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