The paper analyzes the influence of defects detected in a monolithic base slab on the possibility of its further application in the construction of a 25-storey high-rise frame building. Non destructive testing and vertical core sampling techniques are used for the detailed analysis of the monolithic base slab. It is found that irregularities in the procedure during winter concreting of the base slab decreases the strength properties of concrete and provides the defect formation in the slab structure, namely delamination of the lower protective concrete layer and uncovering of working reinforcement. For the safe use of the 25-storey high-rise building, the base slab is proposed to be strengthened by adding in-situ reinforced concrete layer 100 cm thick.