scholarly journals Preconditioned and Genetically Modified Stem Cells for Myocardial Infarction Treatment

2020 ◽  
Vol 21 (19) ◽  
pp. 7301 ◽  
Author(s):  
Kamila Raziyeva ◽  
Aiganym Smagulova ◽  
Yevgeniy Kim ◽  
Saltanat Smagul ◽  
Ayan Nurkesh ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Stem Cells ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Heart Function ◽  
Cellular Reprogramming ◽  
Genetic Manipulations ◽  
Cell Transplantation Therapy ◽  
Transplantation Therapy

Ischemic heart disease and myocardial infarction remain leading causes of mortality worldwide. Existing myocardial infarction treatments are incapable of fully repairing and regenerating the infarcted myocardium. Stem cell transplantation therapy has demonstrated promising results in improving heart function following myocardial infarction. However, poor cell survival and low engraftment at the harsh and hostile environment at the site of infarction limit the regeneration potential of stem cells. Preconditioning with various physical and chemical factors, as well as genetic modification and cellular reprogramming, are strategies that could potentially optimize stem cell transplantation therapy for clinical application. In this review, we discuss the most up-to-date findings related to utilizing preconditioned stem cells for myocardial infarction treatment, focusing mainly on preconditioning with hypoxia, growth factors, drugs, and biological agents. Furthermore, genetic manipulations on stem cells, such as the overexpression of specific proteins, regulation of microRNAs, and cellular reprogramming to improve their efficiency in myocardial infarction treatment, are discussed as well.

scholarly journals Stem cell transplantation therapy for multifaceted therapeutic benefits after stroke

2017 ◽  
Vol 157 ◽  
pp. 49-78 ◽  
Author(s):  
Ling Wei ◽  
Zheng Z. Wei ◽  
Michael Qize Jiang ◽  
Osama Mohamad ◽  
Shan Ping Yu
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Therapeutic Benefits ◽  
Cell Transplantation Therapy ◽  
Transplantation Therapy

scholarly journals Current Status and Future Development of Cell Transplantation Therapy for Periodontal Tissue Regeneration

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Toshiyuki Yoshida ◽  
Kaoru Washio ◽  
Takanori Iwata ◽  
Teruo Okano ◽  
Isao Ishikawa
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
New Technology ◽  
Basic Research ◽  
Current Status ◽  
Periodontal Tissue ◽  
Research Risks ◽  
Cell Transplantation Therapy ◽  
Transplantation Therapy

It has been shown that stem cell transplantation can regenerate periodontal tissue, and several clinical trials involving transplantation of stem cells into human patients have already begun or are in preparation. However, stem cell transplantation therapy is a new technology, and the events following transplantation are poorly understood. Several studies have reported side effects and potential risks associated with stem cell transplantation therapy. To protect patients from such risks, governments have placed regulations on stem cell transplantation therapies. It is important for the clinicians to understand the relevant risks and governmental regulations. This paper describes the ongoing clinical studies, basic research, risks, and governmental controls related to stem cell transplantation therapy. Then, one clinical study is introduced as an example of a government-approved periodontal cell transplantation therapy.

Functional Considerations of Stem Cell Transplantation Therapy for Spinal Cord Repair

2006 ◽  
Vol 23 (3-4) ◽  
pp. 479-495 ◽  
Author(s):  
Gaby U. Enzmann ◽  
Richard L. Benton ◽  
Jason F. Talbott ◽  
Qilin Cao ◽  
Scott R. Whittemore
Keyword(s):  
Spinal Cord ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Spinal Cord Repair ◽  
Cell Transplantation Therapy ◽  
Transplantation Therapy

scholarly journals Amniotic stem cell transplantation therapy for type 1 diabetes: A case report

2013 ◽  
Vol 41 (4) ◽  
pp. 1370-1377 ◽  
Author(s):  
Ying Liu ◽  
Dong-Lin Cao ◽  
Li-Bin Guo ◽  
Sheng-Nan Guo ◽  
Jin-Kai Xu ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Stem Cell ◽  
Case Report ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Cell Transplantation Therapy ◽  
Transplantation Therapy
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