Adipose-Derived Stem Cells as Photodynamic Therapeutic Carriers for Treatment of Glioblastoma Exploiting Reactive Oxygen Species

2021 ◽  
pp. 1-21
Author(s):  
Madeleen Jansen van Rensburg ◽  
Daniella Da Silva ◽  
Anine Crous ◽  
Heidi Abrahamse
Keyword(s):  
Reactive Oxygen Species ◽  
Stem Cells ◽  
Reactive Oxygen ◽  
Adipose Derived Stem Cells ◽  
Oxygen Species

813 DIFFERENTIATION OF ADIPOSE-DERIVED STEM CELLS INTO FAT INVOLVES REACTIVE OXYGEN SPECIES AND UPREGULATION OF ANTIOXIDANT ENZYMES

2012 ◽  
Vol 30 ◽  
pp. e236
Author(s):  
Masayoshi Higuchi ◽  
Gregory J. Dusting ◽  
Hitesh Peshavariya ◽  
Elsa C. Chan ◽  
Guei-Sheung Liu
Keyword(s):  
Reactive Oxygen Species ◽  
Stem Cells ◽  
Antioxidant Enzymes ◽  
Reactive Oxygen ◽  
Adipose Derived Stem Cells ◽  
Oxygen Species

scholarly journals Generation of reactive oxygen species in adipose-derived stem cells: friend or foe?

2011 ◽  
Vol 15 (11) ◽  
pp. 1297-1306 ◽  
Author(s):  
Sang Gyu Park ◽  
Ji Hye Kim ◽  
Ying Xia ◽  
Jong-Hyuk Sung
Keyword(s):  
Reactive Oxygen Species ◽  
Stem Cells ◽  
Reactive Oxygen ◽  
Adipose Derived Stem Cells ◽  
Oxygen Species

scholarly journals The Pivotal Role of Reactive Oxygen Species Generation in the Hypoxia-Induced Stimulation of Adipose-Derived Stem Cells

2011 ◽  
Vol 20 (10) ◽  
pp. 1753-1761 ◽  
Author(s):  
Ji Hye Kim ◽  
So-Hyun Park ◽  
Sang Gyu Park ◽  
Joon-Seok Choi ◽  
Ying Xia ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Stem Cells ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Pivotal Role ◽  
Adipose Derived Stem Cells ◽  
Oxygen Species ◽  
Stimulation Of

scholarly journals Ultraviolet B Preconditioning Enhances the Hair Growth-Promoting Effects of Adipose-Derived Stem Cells Via Generation of Reactive Oxygen Species

2013 ◽  
Vol 22 (1) ◽  
pp. 158-168 ◽  
Author(s):  
Yun-Mi Jeong ◽  
Young Kwan Sung ◽  
Wang-Kyun Kim ◽  
Ji Hye Kim ◽  
Mi Hee Kwack ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Stem Cells ◽  
Hair Growth ◽  
Reactive Oxygen ◽  
Ultraviolet B ◽  
Adipose Derived Stem Cells ◽  
Oxygen Species ◽  
Growth Promoting

Effect of HBO therapy on adipose-derived stem cells, fibroblasts and co-cultures: In vitro study of oxidative stress, angiogenic potential and production of pro-inflammatory growth factors in co-cultures1

2020 ◽  
pp. 1-13
Author(s):  
P. Engel ◽  
M. Ranieri ◽  
O. Felthaus ◽  
S. Geis ◽  
F. Haubner ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Stem Cells ◽  
Wound Healing ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Reactive Oxygen ◽  
Adipose Derived Stem Cells ◽  
Oxygen Species

BACKGROUND: A key moderator of wound healing is oxygen. Wound healing is a dynamic and carefully orchestrated process involving blood cells, cytokines, parenchymal cells (i.e. fibroblasts and mesenchymal stem cells) and extracellular matrix reorganization. Human adipose derived stem cells as well as human fibroblasts produce soluble factors, exhibit diverse effects on inflammation and anti inflammation response and are involved in wound healing processes. Hyperbaric oxygen therapy is an effective adjunct treatment for ischemic disorders such as chronic infection or chronic wounds. In vitro effects of hyperbaric oxygen therapy on human cells were presented in many studies except for those on mono- and co-cultures of human adipose derived stem cells and fibroblasts. OBJECTIVE: The aim of this study was to investigate the effects of hyperbaric oxygen therapy on mono- and co-cultures of human adipose derived stem cells and fibroblasts. METHODS: Mono- and co-cultures from human adipose derived stem cells and fibroblasts were established. These cultures were exposed to hyperbaric oxygen therapy every 24 h for five consecutive days. Measuring experiments were performed on the first, third and fifth day. Therapy effects on the expression of VEGF, IL 6 and reactive oxygen species were investigated. RESULTS: After exposure to hyperbaric oxygen, cell culturess showed a significant increase in the expression of VEGF after 3 and 5 days. All cultures showed significantly reduced formation of reactive oxygen species throughout the experiments. The expression of IL-6 decreased during the experiment in mono-cultures of human adipose derived stem cells and co-cultures. In contrast, mono-cultures of human skin fibroblasts showed an overall significantly increased expression of IL-6. CONCLUSIONS: Hyperbaric oxygen therapy leads to immunmodulatory and proangiogenetic effects in a wound-like enviroment of adipose derived stem cells and fibroblasts.

High glucose-induced reactive oxygen species generation promotes stemness in human adipose-derived stem cells

Cytotherapy ◽  
2016 ◽  
Vol 18 (3) ◽  
pp. 371-383 ◽  
Author(s):  
Nai-Chen Cheng ◽  
Tsung-Yu Hsieh ◽  
Hong-Shiee Lai ◽  
Tai-Horng Young
Keyword(s):  
Reactive Oxygen Species ◽  
Stem Cells ◽  
High Glucose ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Adipose Derived Stem Cells ◽  
Oxygen Species
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