Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia

2022 ◽  
pp. 111-122
Author(s):  
Yoshinobu Maeda ◽  
Akihiko Kawahara ◽  
Yoshiaki Norimatsu
Keyword(s):  
Intraepithelial Neoplasia ◽  
Atypical Hyperplasia

Clonal evolution in paired endometrial intraepithelial neoplasia/atypical hyperplasia and endometrioid adenocarcinoma

2017 ◽  
Vol 67 ◽  
pp. 69-77 ◽  
Author(s):  
Mariano Russo ◽  
James Broach ◽  
Kathryn Sheldon ◽  
Kenneth R. Houser ◽  
Dajiang J. Liu ◽  
...  
Keyword(s):  
Clonal Evolution ◽  
Intraepithelial Neoplasia ◽  
Atypical Hyperplasia ◽  
Endometrioid Adenocarcinoma ◽  
Endometrial Intraepithelial Neoplasia

scholarly journals Neoplasia intraepitelial endometrial: una lesión precursora de cáncer de endometrio

2021 ◽  
Vol 81 (01) ◽  
pp. 75-85
Author(s):  
Ernesto Lara ◽  
Keyword(s):  
Endometrial Cancer ◽  
Endometrial Hyperplasia ◽  
Intraepithelial Neoplasia ◽  
Atypical Hyperplasia ◽  
Classification Systems ◽  
World Health ◽  
Type I ◽  
Female Population ◽  
Typical Sequence ◽  
Endometrial Intraepithelial Neoplasia

Endometrial cancer represents worldwide the sixth most common malignant pathology in the female population, the endometroid type constitutes the most common form, usually developed from a typical sequence of endometrial hyperplasia secondary to sustained exposure to unopposed estrogens balanced by progestogens. Different classification systems for endometrial hyperplasia have been described, the most recent, published by the World Health Organization in 2014, proposes two categories: 1) hyperplasia without atypia, and 2) atypical hyperplasia or endometrial intraepithelial neoplasia. This classification avoids confusion due to the different terms in use and reflects a better understanding of the pathology behavior. Atypical hyperplasia or endometrial intraepithelial neoplasia is considered a precursor lesion to endometrial carcinoma type I. Health professionals must handle standardized terminology, accurately diagnose this entity, and ensure proper treatment of it. Keywords: Endometrial intraepithelial neoplasia, Endometrial hyperplasia, Atypical hyperplasia, Endometrial cancer.

COMPARISON OF ENDOMETRIAL INTRAEPITHELIAL NEOPLASIA & WHO CLASSIFIED ENDOMETRIAL HYPERPLASIA IN PREDICTING THE RISK OF PROGRESSION TO ENDOMETRIAL CARCINOMA

2021 ◽  
pp. 59-61
Author(s):  
Bansi Kavar ◽  
Neeru Dave
Keyword(s):  
Endometrial Cancer ◽  
Endometrial Hyperplasia ◽  
Intraepithelial Neoplasia ◽  
Atypical Hyperplasia ◽  
Cytological Atypia ◽  
Endometrial Intraepithelial Neoplasia ◽  
Risk Of Progression ◽  
Classi Cation ◽  
Cation System ◽  
Sampling Procedures

Background: Endometrial hyperplasia is the precursor lesion of most endometrial cancers of endometrioid type. The most commonly used classication system for endometrial hyperplasia is WHO 1994 classication system in which architecture disruption and cytological atypia are used to identify four types of endometrial hyperplasia including simple or complex hyperplasia with or without atypia. Newer EIN diagnosis by cytological atypia is of great consideration for the progression to endometrial cancer. Material And Methods: The study consists of 100 cases of WHO classied endometrial hyperplasia for period of 4 yrs from 2015 to 2019. Type of sampling procedures- dilation & curettage, endometrial biopsy and fractional curettage. Objective: 1. To discuss revised criteria for recognition of endometrial intraepithelial neoplasia (EIN). 2. To nd out the sensitivity of endometrial intraepithelial neoplasia (EIN) classication in predicting the risk of malignancy. Results: This study consists of 100 cases of endometrial hyperplasia. Patients were mostly postmenopausal & presented with abnormal vaginal bleeding. From WHO classied endometrial lesions, 2 out of 35 cases of simple typical hyperplasia, 10 out of 14 cases of complex typical hyperplasia,12 out of 20 cases of simple atypical hyperplasia and 20 out of 21 cases of complex atypical hyperplasia were reclassied as EI N. Conclusion: To estimate the risk of progression to carcinoma and guide clinical management, the histo-pathologic diagnosis of endometrial hyperplastic lesion is very important, specially the diagnosis of EIN lesions. EIN carries a much greater risk of progression to endometrial cancer than other WHO classied endometrial hyperplasia.

Congruence Between 1994 WHO Classification of Endometrial Hyperplasia and Endometrial Intraepithelial Neoplasia System

2019 ◽  
Vol 153 (1) ◽  
pp. 40-48 ◽  
Author(s):  
Antonio Travaglino ◽  
Antonio Raffone ◽  
Gabriele Saccone ◽  
Massimo Mascolo ◽  
Maurizio Guida ◽  
...  
Keyword(s):  
Endometrial Hyperplasia ◽  
Meta Analysis ◽  
Intraepithelial Neoplasia ◽  
Atypical Hyperplasia ◽  
Classification Systems ◽  
World Health ◽  
Endometrial Intraepithelial Neoplasia ◽  
Subgroup Analyses ◽  
Health Organization

Abstract Objectives To assess congruence between World Health Organization (WHO) 1994 and endometrial intraepithelial neoplasia (EIN) classification systems of endometrial hyperplasia. Methods Systematic review and meta-analysis were performed by searching electronic databases for studies that classified endometrial hyperplasia according to both WHO 1994 and EIN systems. Congruence was based on the rate of specimens classified as EIN in WHO categories, which should be virtually 0.000 in nonatypical hyperplasia (NAH) and 1.000 in atypical hyperplasia (AH). Subgroup analyses were performed based on architecture complexity. Results Eight studies with 1,352 hyperplasias were included. Congruence with EIN criteria was fair in NAH (0.241) and moderate in AH (0.815). Subgroup analyses of NAH showed high congruence in simple NAH (0.065), null in complex NAH (0.517), null in simple AH (0.148), and high in complex AH (0.901). Conclusions WHO 1994 system is not congruent with the EIN system and cannot be directly translated into a dual classification.

Nuclear Beta-Catenin Expression in Endometrioid Intraepithelial Neoplasia (Atypical Hyperplasia) Does Not Predict Carcinoma on Subsequent Hysterectomy

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Martha F. Wright ◽  
Sarah Fitzlaff ◽  
Autumn Wyeth ◽  
Matthew Zaragoza-Watkins ◽  
Mirna B. Podoll ◽  
...  
Keyword(s):  
Intraepithelial Neoplasia ◽  
Atypical Hyperplasia ◽  
Beta Catenin

Benign Prostatic Hypertrophy, Prostatic Cancer and Preneoplastic Lesions

1992 ◽  
Vol 59 (1) ◽  
pp. 58-60
Author(s):  
F. Zattoni
Keyword(s):  
Prostatic Cancer ◽  
Benign Prostatic Hypertrophy ◽  
Intraepithelial Neoplasia ◽  
Peripheral Zone ◽  
Prostatic Intraepithelial Neoplasia ◽  
Atypical Hyperplasia ◽  
Prostatic Hypertrophy ◽  
Prostatic Tissue ◽  
Preneoplastic Lesions ◽  
Hyperplastic Gland

Quite recently two dysplastic lesions have been found in prostatic tissue: atypical hyperplasia (AH), found in the periurethral zone, and prostatic intraepithelial neoplasia (PIN), present in the peripheral zone of the prostate. These lesions are likely to be considered as preneoplastic lesions. Theoretically they could be interpreted as the link between normal prostatic tissue and the cancer. It has also been suggested that BPH possibly contributes to the carcinogenetic process due to the demonstrated modifications occuring in the hyperplastic gland.

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