Buccal Delivery of Curcumin to Address Its Poor Gastrointestinal Stability

IRC-SET 2018 ◽  
2019 ◽  
pp. 321-333
Author(s):  
Bing Lim ◽  
Mak Wai Theng
Keyword(s):  
Buccal Delivery

Development, Characterization and Optimization of Mucoadhesive Tablet for Buccal Delivery of Domperidone

2019 ◽  
Vol 9 (1) ◽  
pp. 37-49
Author(s):  
Jagdale Sachin ◽  
Panbude Aishwarya ◽  
Navasare Priya
Keyword(s):  
Drug Release ◽  
Factorial Design ◽  
Research Work ◽  
Wet Granulation ◽  
Buccal Delivery ◽  
Scanning Calorimetry ◽  
Mucoadhesive Polymers ◽  
First Pass Metabolism ◽  
First Pass ◽  
Pass Metabolism

Background and Objective: Upon oral administration domeperidone is rapidly absorbed, but subjected to the first pass effect which lowers systemic bioavailability to 15%. Mucoadhesive tablet can remain attached to buccal mucosa and becomes capable of bypassing hepatic first-pass metabolism to improve absorption directly into systemic circulation. The present research work was carried with an aim to develop, evaluate and optimize mucoadhesive tablet containing domperidone (DOME) for buccal delivery using different bio-adhesive polymeric combinations. </P><P> Methods: The buccal tablets were formulated by wet granulation method using isopropyl alcohol. The preliminary formulations were prepared using combinations of HPMC K4, HPMC K15, HPMC K100, HPMC E5 as mucoadhesive polymers. 32 full factorial design was applied to determine the effect of independent variables like concentration of mucoadhesive polymers (HPMC K15 and HPMC K100) over dependent variables like mucoadhesive properties (swelling index, bioadhesive strength and in vitro drug release). The prepared mucoadhesive tablets were evaluated for their tablet properties and mucoadhesive properties. The interactions between drug and polymers were studied by Fourier Transform Infrared Spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC). </P><P> Results: All formulations of factorial design showed satisfactory physicochemical, mechanical and bioadhesive characteristics. The formulation F9 exhibited maximum cumulative drug release, mucoadhesive strength and swelling index. Conclusion: The developed buccal tablet of domperidone might prove alternative to bypass the hepatic first pass metabolism and to avoid degradation which in turn may result in reducing the frequency of administration. Thus, mucoadhesive tablet of domeperidone may become viable alternative overcoming the side effects; achieving greater therapeutic effectiveness and improving the patient compliance.

scholarly journals Chitosan-based films for the sustained release of peptides: a new era in buccal delivery?

2014 ◽  
Vol 5 (5) ◽  
pp. 497-500 ◽  
Author(s):  
Joshua S Boateng ◽  
Obinna Okeke
Keyword(s):  
Sustained Release ◽  
Buccal Delivery ◽  
New Era

Double-phase hydrogel for buccal delivery of tramadol

2011 ◽  
Vol 38 (4) ◽  
pp. 468-483 ◽  
Author(s):  
Rabab Kamel ◽  
Azza Mahmoud ◽  
Gina El-Feky
Keyword(s):  
Buccal Delivery ◽  
Double Phase

scholarly journals A mussel-inspired film for adhesion to wet buccal tissue and efficient buccal drug delivery

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Shanshan Hu ◽  
Xibo Pei ◽  
Lunliang Duan ◽  
Zhou Zhu ◽  
Yanhua Liu ◽  
...  
Keyword(s):  
Oral Delivery ◽  
Wound Closure ◽  
Ex Vivo ◽  
Covalent Bonding ◽  
Mucosal Barrier ◽  
Buccal Delivery ◽  
Tissue Adhesives ◽  
Drug Bioavailability ◽  
Buccal Drug Delivery ◽  
Strong Adhesion

AbstractAdministration of drugs via the buccal route has attracted much attention in recent years. However, developing systems with satisfactory adhesion under wet conditions and adequate drug bioavailability still remains a challenge. Here, we propose a mussel-inspired mucoadhesive film. Ex vivo models show that this film can achieve strong adhesion to wet buccal tissues (up to 38.72 ± 10.94 kPa). We also demonstrate that the adhesion mechanism of this film relies on both physical association and covalent bonding between the film and mucus. Additionally, the film with incorporated polydopamine nanoparticles shows superior advantages for transport across the mucosal barrier, with improved drug bioavailability (~3.5-fold greater than observed with oral delivery) and therapeutic efficacy in oral mucositis models (~6.0-fold improvement in wound closure at day 5 compared with that observed with no treatment). We anticipate that this platform might aid the development of tissue adhesives and inspire the design of nanoparticle-based buccal delivery systems.

scholarly journals Chitosan gels for buccal delivery of Schinus molle L. essential oil in dogs: characterization and antimicrobial activity in vitro

2020 ◽  
Vol 92 (4) ◽  
Author(s):  
MELINA C.C. ALVES ◽  
DOUGLAS S.A. CHAVES ◽  
BYANCA R. BENEVENUTO ◽  
BEATRIZ O. DE FARIAS ◽  
SHANA M.O. COELHO ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Essential Oil ◽  
Buccal Delivery ◽  
Schinus Molle

Development, optimization and in vivo characterization of domperidone-controlled release hot-melt-extruded films for buccal delivery

2015 ◽  
Vol 42 (3) ◽  
pp. 473-484 ◽  
Author(s):  
Chinna Reddy Palem ◽  
Narendar Reddy Dudhipala ◽  
Sunil Kumar Battu ◽  
Michael A. Repka ◽  
Madhusudan Rao Yamsani
Keyword(s):  
Controlled Release ◽  
Buccal Delivery ◽  
Extruded Films ◽  
In Vivo Characterization ◽  
Hot Melt

Chitosan lactate wafer as a platform for the buccal delivery of tizanidine HCl: In vitro and in vivo performance

2014 ◽  
Vol 467 (1-2) ◽  
pp. 100-112 ◽  
Author(s):  
Galal M. El-Mahrouk ◽  
Omaima N. El-Gazayerly ◽  
Ahmed A. Aboelwafa ◽  
Maie S. Taha
Keyword(s):  
Buccal Delivery ◽  
Chitosan Lactate

Characterization of chitosan–magnesium aluminum silicate nanocomposite films for buccal delivery of nicotine

2013 ◽  
Vol 55 ◽  
pp. 24-31 ◽  
Author(s):  
Thaned Pongjanyakul ◽  
Wanwisa Khunawattanakul ◽  
Clare J. Strachan ◽  
Keith C. Gordon ◽  
Satit Puttipipatkhachorn ◽  
...  
Keyword(s):  
Nanocomposite Films ◽  
Aluminum Silicate ◽  
Buccal Delivery ◽  
Magnesium Aluminum Silicate

Modified glutinous rice starch-chitosan composite films for buccal delivery of hydrophilic drug

2020 ◽  
Vol 245 ◽  
pp. 116556 ◽  
Author(s):  
May Thu Soe ◽  
Thaned Pongjanyakul ◽  
Ekapol Limpongsa ◽  
Napaphak Jaipakdee
Keyword(s):  
Composite Films ◽  
Rice Starch ◽  
Buccal Delivery ◽  
Glutinous Rice ◽  
Hydrophilic Drug ◽  
Chitosan Composite
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