Modified glutinous rice starch-chitosan composite films for buccal delivery of hydrophilic drug

This study investigated the effect of lipid types (oleic acid, palm oil, and margarine) and their concentrations (0, 10, 20, 30, 40, and 50wt%) on the water vapor permeability (WVP), tensile strength (TS), percentage of elongation at break (%E), and structure of emulsified rice starch-chitosan composite film. The influence of rice starch-chitosan composite film incorporated with lipids in controlling the moisture transfer in moisture-sensitive products was determined by wrapping a low aw-type cracker product in rice starch-chitosan composite film. TS and WVP of rice starch-chitosan composite film decreased with the addition of lipids, whereas %E increased in these films. Addition of lipids significantly raised film yellowness for composite films. The results showed that films added with oleic acid gave higher L*, b*, and chroma values but lower a* value than margarine and palm oil, respectively. The lower transparency of the films was noticed when a greater amount of lipid was incorporated (p < 0.05). Oleic acid-incorporated films provided the films with smoother surface and higher values of TS and %E but lower WVP than margarine and palm oil, respectively. Wrapping cracker samples in the rice starch-chitosan composite film incorporated with oleic acid could maintain the hardness and provide longer shelf life and lower moisture content than synthetic polyvinyl chloride film (PVC) and unwrapped (reference) crackers, respectively.

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Evaluation of swelling properties and drug release from mechanochemical pre-gelatinized glutinous rice starch matrix tablets by near infrared spectroscopy

Journal of Near Infrared Spectroscopy ◽

10.1177/0967033520982351 ◽

2021 ◽

pp. 096703352098235

Author(s):

Tomomi Takaku ◽

Yusuke Hattori ◽

Tetsuo Sasaki ◽

Tomoaki Sakamoto ◽

Makoto Otsuka

Keyword(s):

Drug Release ◽

Near Infrared ◽

Nir Spectroscopy ◽

Matrix Tablets ◽

Rice Starch ◽

Release Time ◽

Swelling Properties ◽

X Ray ◽

Glutinous Rice ◽

Pharmaceutical Properties

The effect of grinding on the pharmaceutical properties of matrix tablets consisting of ground glutinous rice starch (GRS) and theophylline (TH) was predicted by near infrared (NIR) spectroscopy. Ground GRS samples were prepared by grinding GRS in a planetary ball mill for 0-120 min, measured by X-ray diffractometry (XRD) and NIR, and then evaluated for crystallinity (%XRD) based on XRD profiles. Tablets containing TH (5 w/w%), ground GRS (94 w/w%), and magnesium stearate (1 w/w%) were formed by compression. Gel-forming and drug-release processes of the tablets were measured using a dissolution instrument with X-ray computed tomography (XCT). Swelling ratio (SWE) and mean drug-release time (MDT) were evaluated based on XCT and drug-release profiles, respectively. Calibration models for predicting percent %XRD, MDT, and SWE were constructed based on the NIR of ground GRS using partial least-squares. The results indicated the possibility of controlling the pharmaceutical properties of matrix tablets by altering the pre-gelatinization of GRS based on changes in their NIR spectra during the milling process.

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Dielectric properties: a gateway to antibacterial assay—a case study of low-density polyethylene/chitosan composite films

Polymer Journal ◽

10.1038/pj.2014.19 ◽

2014 ◽

Vol 46 (7) ◽

pp. 422-429 ◽

Cited By ~ 9

Author(s):

Madathil Sunilkumar ◽

Ambalakkandy Abdul Gafoor ◽

Abdulaziz Anas ◽

Areepuravan Parakkal Haseena ◽

Athiyanathil Sujith

Keyword(s):

Dielectric Properties ◽

Composite Films ◽

Low Density Polyethylene ◽

Low Density ◽

Antibacterial Assay ◽

Chitosan Composite

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A Study of the Preparation of Silk Sericin/Chitosan Composite Film for Future Wound Dressing Applications

Applied Mechanics and Materials ◽

10.4028/www.scientific.net/amm.804.179 ◽

2015 ◽

Vol 804 ◽

pp. 179-182 ◽

Cited By ~ 3

Author(s):

Piyapong Pankaew ◽

Pattarinee Klumdoung ◽

Kittisakchai Naemchanthara

Keyword(s):

Composite Film ◽

Wound Dressing ◽

Composite Films ◽

Fine Powder ◽

Silk Sericin ◽

Vis Spectroscopy ◽

Silk Worm ◽

Bombyx Mori Silk ◽

Film Development ◽

Chitosan Composite

Silk sericin/chitosan composite films were successfully prepared for possible future wound dressing applications. To prepare the chitosan, shrimp shells were first washed and finely ground to obtain a fine powder before extracting the chitosan using a chemical reaction method. The sericin was extracted from Thai raw cocoons of Bombyx mori silk worm via boiling and drying. To prepare the silk sericin/chitosan composite films, the silk sericin and chitosan solutions with varying volume ratios were mixed in a magnetic stirrer for 30 minutes. They were then dropped on to a plastic mold. The sample was dried at a temperature of 50 °C. The prepared composite films were characterized using UV-VIS spectroscopy, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscope (SEM). The results from our studies could provide a method for future composite film development.

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Effects of the Surface Characteristics of Nano-Crystalline and Micro-Particle Calcium Phosphate/Chitosan Composite Films on the Behavior of Human Mesenchymal Stem Cells In Vitro

Journal of Biomaterials Science Polymer Edition ◽

10.1163/092050610x540431 ◽

2011 ◽

Vol 22 (17) ◽

pp. 2369-2388 ◽

Cited By ~ 10

Author(s):

Y.-T. Lee ◽

B.-Y. Yu ◽

H.-J. Shao ◽

C.-H. Chang ◽

Y.-M. Sun ◽

...

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Calcium Phosphate ◽

Composite Films ◽

Human Mesenchymal Stem Cells ◽

Surface Characteristics ◽

Nano Crystalline ◽

Chitosan Composite

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Effect of citric acid induced crosslinking on the structure and properties of potato starch/chitosan composite films

Food Hydrocolloids ◽

10.1016/j.foodhyd.2019.105208 ◽

2019 ◽

Vol 97 ◽

pp. 105208 ◽

Cited By ~ 21

Author(s):

Hejun Wu ◽

Yanlin Lei ◽

Junyu Lu ◽

Rui Zhu ◽

Di Xiao ◽

...

Keyword(s):

Citric Acid ◽

Potato Starch ◽

Composite Films ◽

Structure And Properties ◽

Chitosan Composite

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The influence of the addition of transglutaminase at different phase on the film and film forming characteristics of whey protein concentrate-carboxymethyl chitosan composite films

Food Packaging and Shelf Life ◽

10.1016/j.fpsl.2020.100546 ◽

2020 ◽

Vol 25 ◽

pp. 100546

Author(s):

Shujuan Jiang ◽

Lili Zou ◽

Yaqi Hou ◽

Fang Qian ◽

Yanfeng Tuo ◽

...

Keyword(s):

Whey Protein ◽

Composite Films ◽

Carboxymethyl Chitosan ◽

Whey Protein Concentrate ◽

Protein Concentrate ◽

Film Forming ◽

Forming Characteristics ◽

Chitosan Composite

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Preparation of Glutinous Rice Starch Nanofibers by Electrospinning

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.506.230 ◽

2012 ◽

Vol 506 ◽

pp. 230-233 ◽

Cited By ~ 4

Author(s):

P. Jaiturong ◽

Krit Sutjarittangtham ◽

Sukum Eitssayeam ◽

Jakkapan Sirithunyalug

Keyword(s):

Chemical Structure ◽

Chemical Properties ◽

Rice Starch ◽

High Porosity ◽

High Voltage Power Supply ◽

Electrospinning Technique ◽

Physical Chemical ◽

Glutinous Rice ◽

Ft Ir ◽

Basic Characteristics

Glutinous rice starch (GRS) is produced from glutinous rice which is commonly cultivated in the Northeast of Thailand. GRS contains two types of glucose polymers which are amylose and amylopectin. Glutinous rice starch nanofibers (GNF) can be produced by an electrospinning technique. This is not a complicated method but needs a high voltage power supply. The aim of this study was to understand the production of GNF and physical-chemical properties of GNF. The morphology of GNF was examined by scanning electron microscopy. The characteristics of GNF are high porosity, flake multi-layers and a high swelling power. The Electrospinning technique did not change the chemical structure of GRS based on an FT-IR evaluation. This research revealed the basic characteristics of electrospun glutinous starch for use in various applications in the future.

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