Phosphoglucomutase (PGM) and Esterase-6 (EST-6) alleles in Drosophila melanogaster: An attempt to detect linkage disequilibrium

Genetica ◽  
1978 ◽  
Vol 49 (2-3) ◽  
pp. 225-227 ◽  
Author(s):  
G. Trippa ◽  
G. A. Danieli ◽  
R. Costa ◽  
R. Scozzari
Keyword(s):  
Drosophila Melanogaster ◽  
Linkage Disequilibrium ◽  
Esterase 6

scholarly journals Contrasting Histories of Three Gene Regions Associated With In(3L)Payne of Drosophila melanogaster

Genetics ◽  
1996 ◽  
Vol 144 (4) ◽  
pp. 1565-1575 ◽  
Author(s):  
Esteban Hasson ◽  
Walter F Eanes
Keyword(s):  
Drosophila Melanogaster ◽  
Sequence Variation ◽  
Present Report ◽  
Genetic Exchange ◽  
Nucleotide Variation ◽  
Distal Breakpoint ◽  
Esterase 6 ◽  
The Common ◽  
Neutrality Tests ◽  
Hsp83 Gene

In the present report, we studied nucleotide variation in three gene regions of Drosophila melanogaster, spanning >5 kb and showing different degrees of association with the cosmopolitan inversion In(3-L)Payne. The analysis of sequence variation in the regions surrounding the breakpoints and the heat shock 83 (Hsp83) gene locus, located close to the distal breakpoint, revealed the absence of shared polymorphisms and the presence of a number of fixed differences between arrangements, indicating absence of genetic exchange. In contrast, for the esterase-6 gene region, located in the center of the inversion, we observed the presence of shared polymorphisms between arrangements suggesting genetic exchange. In the regions close to the breakpoints, the common St arrangement is 10 times more polymorphic than inverted chromosomes. We propose that the lack of recombination between arrangements in these regions coupled with genetic hitchhiking is the best explanation for the low heterozygosity observed in inverted lines. Using the data for the breakpoints, we estimate that this inversion polymorphism is around 0.36 million yr old. Although it is widely accepted that inversions are examples of balanced polymorphisms, none of the current neutrality tests including our Monte Carlo simulations showed significant departure from neutral expectations.

scholarly journals The number and distribution of esterase 6 alleles in populations of Drosophila melanogaster

Heredity ◽  
1989 ◽  
Vol 63 (2) ◽  
pp. 203-208 ◽  
Author(s):  
J Labate ◽  
A Bortoli ◽  
A Y Game ◽  
P H Cooke ◽  
J G Oakeshott
Keyword(s):  
Drosophila Melanogaster ◽  
Esterase 6

Genetics and Biochemistry of Esterase-6 in Drosophila Melanogaster

1982 ◽  
pp. 285-288 ◽  
Author(s):  
Rodolfo Costa ◽  
Gian Antonio Danieli ◽  
Loredana Nigro
Keyword(s):  
Drosophila Melanogaster ◽  
Esterase 6

scholarly journals PROPERTIES AND EVOLUTIONARY POTENTIAL OF NEWLY INDUCED TANDEM DUPLICATIONS IN DROSOPHILA MELANOGASTER

Genetics ◽  
1982 ◽  
Vol 102 (1) ◽  
pp. 75-89
Author(s):  
Paul A Roberts ◽  
David J Broderick
Keyword(s):  
Drosophila Melanogaster ◽  
Linkage Disequilibrium ◽  
Tandem Duplication ◽  
Polytene Chromosomes ◽  
Primary Source ◽  
Evolutionary Potential ◽  
X Ray ◽  
Fitness Effects ◽  
New Genes ◽  
Tandem Duplications

ABSTRACT Most of some 33 X-ray-induced duplications recovered as Suppressors of Minute loci proved to be direct tandem duplications. When heterozygous, most duplications were crossover suppressors, and duplications of short to moderate size did not reduce the fitness of their bearers. Crossover suppression by tandem duplication may be attributed to intrastrand foldbacks of the type regularly seen in somatic polytene chromosomes. As a consequence, linkage disequilibrium between duplicated elements and normal chromosomes should be more profound than has been supposed. Tandem duplications appear to be predisposed by reason of frequency of generation, crossover suppression and fitness effects to serve as the primary source of new genes.

scholarly journals Studies of esterase 6 in Drosophila melanogaster: XIV. Variation of esterase 6 levels controlled by unlinked genes in natural populations

1984 ◽  
Vol 43 (2) ◽  
pp. 181-190 ◽  
Author(s):  
Craig S. Tepper ◽  
Anne L. Terry ◽  
James E. Holmes ◽  
Rollin C. Richmond
Keyword(s):  
Drosophila Melanogaster ◽  
Structural Gene ◽  
X Chromosome ◽  
Genetic Background ◽  
Natural Populations ◽  
Regulatory Elements ◽  
Regulatory Locus ◽  
The Third ◽  
Esterase 6 ◽  
Activity Modifiers

SUMMARYThe esterase 6 (Est-6) locus in Drosophila melanogaster is located on the third chromosome and is the structural gene for a carboxylesterase (E.C.3.1.1.1) and is polymorphic for two major electromorphs (slow and fast). Isogenic lines containing X chromosomes extracted from natural populations and substituted into a common genetic background were used to detect unlinked factors that affect the activity of the Est-6 locus. Twofold activity differences of esterase 6 (EST 6) were found among males from these derived lines, which differ only in their X chromosome. These unlinked activity modifiers identify possible regulatory elements. Immunoelectrophoresis was used to estimate quantitatively the levels of specific cross-reacting material in the derived lines. The results show that the variation in activity is due to differences in the amount of EST 6 present. The data are consistent with the hypothesis that there is at least one locus on the X chromosome that regulates the synthesis of EST 6 and that this regulatory locus may be polymorphic in natural populations.

scholarly journals Linkage disequilibrium in experimental populations of Drosophila simulans: a test of the random drift hypothesis

1987 ◽  
Vol 50 (3) ◽  
pp. 187-193
Author(s):  
Catherine Montchamp-Moreau ◽  
Mariano Katz
Keyword(s):  
Linkage Disequilibrium ◽  
Genetic Drift ◽  
Natural Populations ◽  
Aldehyde Oxidase ◽  
Drosophila Simulans ◽  
Random Drift ◽  
Esterase 6 ◽  
Experimental Populations ◽  
Experimental Values ◽  
Neutralist Hypothesis

SummaryLinkage disequilibrium between five polymorphic enzymic loci of the third chromosome (Esterase-6, Phosphoglucomutase, Esterase-C, Aldehyde Oxidase and Acid Phosphatase) was studied in experimental populations of Drosophila simulans. Gametic data were obtained by mating sampled males with homozygous females at the five loci. Four cage populations were initiated with flies caught from natural populations. Extensive linkage disequilibrium was detected after 25 or 34 generations. The effective size of these populations was estimated about 400. Monte-Carlo simulations were performed in order to determine whether the observed disequilibria could be due to genetic drift. The observed probability distribution of the experimental values of r (the gametic correlation coefficient) was consistent with the distribution expected under random genetic drift. Our results are thus in accordance with the neutralist hypothesis.

Studies of esterase 6 in Drosophila melanogaster. XIII. Purification and characterization of the two major isozymes

1983 ◽  
Vol 21 (9-10) ◽  
pp. 1019-1040 ◽  
Author(s):  
Suresh D. Mane ◽  
Craig S. Tepper ◽  
Rollin C. Richmond
Keyword(s):  
Drosophila Melanogaster ◽  
Purification And Characterization ◽  
Esterase 6
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