Quantification of in vitro growth and synthesis in rabbit middle ear epithelial cells

1996 ◽  
Vol 253 (7) ◽  
Author(s):  
L.P. Schousboe ◽  
S. Blegvad ◽  
T. Ovesen

1997 ◽  
Vol 75 (6) ◽  
pp. 855-859 ◽  
Author(s):  
G Castrilli ◽  
D Tatone ◽  
MG Diodoro ◽  
S Rosini ◽  
M Piantelli ◽  
...  


1985 ◽  
Vol 90 (2) ◽  
pp. 439-450 ◽  
Author(s):  
A.C. Nieburgs ◽  
P.T. Picciano ◽  
J.H. Korn ◽  
T. McCalister ◽  
C. Allred ◽  
...  


1976 ◽  
Vol 19 (5) ◽  
pp. 969-970
Author(s):  
Michael D. Parker ◽  
Grace P. Kerby


1995 ◽  
Vol 113 (2) ◽  
pp. P122-P122
Author(s):  
Jizhen Lin ◽  
Youngki Kim ◽  
Chris Lees ◽  
Steven K. Juhn


2012 ◽  
Vol 77 (5) ◽  
pp. 1014-1020 ◽  
Author(s):  
S. Nandi ◽  
S. Mondal ◽  
I.J. Reddy




1996 ◽  
Vol 105 (11) ◽  
pp. 916-921 ◽  
Author(s):  
Jizhen Lin ◽  
Youngki Kim ◽  
Frank Ondrey ◽  
Chris Lees ◽  
Steven K. Juhn

Lipoxygenase is an enzyme that metabolizes arachidonic acid down to leukotrienes. Recent studies have shown that the enzyme is implicated in mucous glycoprotein (MGP) secretion stimulated by inflammatory mediators in the airways, suggesting its possible role in secretion of MGP from middle ear epithelial cells. To investigate a correlation between MGP secretion and the arachidonic acid metabolites, we examined the effects of nordihydroguaretic acid (NDGA, both a cyclooxygenase and lipoxygenase inhibitor), low-dose indomethacin (an inhibitor of cyclooxygenase), and A63162 (an inhibitor of lipoxygenase) on MGP secretion in cultured chinchilla middle ear epithelial cells. It was found that lipoxygenase inhibition led to reduction of MGP secretion from cultured chinchilla middle ear epithelial cells, while cyclooxygenase inhibition did not. Both cyclooxygenase and lipoxygenase inhibition resulted in profound blockage of MGP secretion in baseline and platelet activating factor-stimulated MGP secretion. It was concluded, therefore, that MGP secretion was linked to arachidonic acid metabolites, especially lipoxygenase products.



1993 ◽  
Vol 18 (5) ◽  
pp. 400-405 ◽  
Author(s):  
THERESE OVESEN ◽  
MICHAEL GAIHEDE ◽  
THOMAS LEDET




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