Short-term activity cycles in ants: age-related changes in tempo and colony synchrony

1992 ◽  
Vol 31 (3) ◽  
Author(s):  
BlaineJ. Cole
2021 ◽  
Vol 12 (1) ◽  
pp. 97
Author(s):  
Gagan Bajaj ◽  
DasmineFraclita D'Souza ◽  
VinithaMary George ◽  
Sudhin Karuppali ◽  
JayashreeS Bhat

Endocrinology ◽  
2010 ◽  
Vol 151 (8) ◽  
pp. 3783-3794 ◽  
Author(s):  
Dominique H. Eghlidi ◽  
Gwendolen E. Haley ◽  
Nigel C. Noriega ◽  
Steven G. Kohama ◽  
Henryk F. Urbanski

The neuropeptides kisspeptin, neurokinin B, and dynorphin A (collectively abbreviated as KNDy) are, respectively, encoded by KiSS-1, NKB, and PDYN and are coexpressed by neurons of the hypothalamic arcuate nucleus (ARC). Here, using quantitative real-time PCR, we examined age-related changes in the expression of genes encoding KNDy and associated receptors G protein-coupled receptor 54 (encoded by GPR54), neurokinin 3 receptor (encoded by NK3), and κ-opioid receptor (encoded by KOR), in the female rhesus macaque ARC-median eminence (ARC-ME). Expression of KiSS-1 and NKB was highly elevated in old perimenopausal compared with young or middle-aged premenopausal animals. To test whether these age-related changes could be attributed to perimenopausal loss of sex steroids, we then examined KNDy, GPR54, NK3, and KOR expression changes in response to ovariectomy (OVX) and exposure to 17β-estradiol (E2). Short-term (7 months) OVX (with or without 1 month of estrogen replacement) failed to modulate the expression of any of the KNDy-related genes. In contrast, long-term (∼4 yr) OVX significantly increased KiSS-1 and NKB expression, and this was reversed by E2 administration. Finally, we examined the expression of KNDy-related genes in young adult females during the early follicular, late follicular, or midluteal phases of their menstrual cycle but found no difference. Together, the results suggest that short-term alterations in circulating E2 levels, such as those occurring during the menstrual cycle, may have little effect on the ARC-ME expression of KNDy and associated receptors. Nevertheless, they clearly demonstrate that loss of ovarian steroid negative feedback that occurs during perimenopause plays a major role in modulating the activity of KNDy circuits of the aging primate ARC-ME.


2008 ◽  
Vol 40 (Supplement) ◽  
pp. S261
Author(s):  
Michael J. Hartman ◽  
Joel T. Cramer ◽  
Debra A. Bemben ◽  
Mark A. Anderson ◽  
Allen W. Knehans ◽  
...  

Neuroscience ◽  
2004 ◽  
Vol 129 (1) ◽  
pp. 119-127 ◽  
Author(s):  
M.M. Ramsey ◽  
J.L. Weiner ◽  
T.P. Moore ◽  
C.S. Carter ◽  
W.E. Sonntag

2020 ◽  
Author(s):  
Julia Marianna Scordo ◽  
Tucker J. Piergallini ◽  
Nicole D Reuter ◽  
Colwyn A. Headley ◽  
Vida L. Hodara ◽  
...  

Abstract Background - Individuals over the age of 65 are highly susceptible to infectious diseases, which account for one-third of deaths in this age group. Vaccines are a primary tool to combat infection, yet they are less effective in the elderly population. While many groups have aimed to address this problem by studying vaccine-induced peripheral blood responses in the elderly, work from our lab and others demonstrate that immune responses to vaccination and infectious challenge may differ between tissue sites and the periphery. To improve health outcomes in our aged population, we must study vaccine responses in the tissue. Here we established an in vivo delayed-type hypersensitivity model of Mycobacterium bovis BCG vaccination and tuberculin skin test (TST) in adult and aged baboons. Vaccination generates BCG-specific immune cells that are recruited to the skin upon tuberculin challenge. We tested short-term recall responses (8 weeks post-vaccination) and long term recall responses (25 weeks post-vaccination) by performing skin punch biopsies around the site of tuberculin injection. In parallel, we determined BCG-induced responses in the peripheral blood of vaccinated animals. Results - In short term recall responses, we found increased oxidation and decreased production of immune proteins in aged baboon skin at the site of TST challenge, in comparison to adult skin. Differences between adult and aged animals normalized in the long term response to tuberculin. Phenotypic analysis of aged peripheral blood cells found several age-related changes in immune cell populations, independent of BCG vaccination, and no impairment in functional responses. Moreover, aged peripheral blood mononuclear cells had increased migration in vitro, suggesting that age-related changes in the tissue in vivo impairs aged immune recall responses to antigenic challenge. Conclusions - These findings highlight the impact of age-associated changes in the local tissue environment in memory recall responses, which may be more broadly applied to the study of other tissues. Moreover, these findings should be considered in future studies aimed at understanding and improving aging immune responses to vaccination and tissue challenge.


2000 ◽  
Vol 13 (4) ◽  
pp. 316-326 ◽  
Author(s):  
Martin D. Higbee ◽  
Cecilia M. Plaza ◽  
Joy Dunkelbarger-Reed

Insomnia is a common complaint in the geriatric population with studies indicating that 23-34% of elderly report symptoms of insomnia. Age-related changes in sleep physiology, diseases common in the elderly, and drug therapies common in the treatment of these diseases may result in difficulties with sleep. Managing these complaints requires a thorough evaluation to determine the etiology of insomnia since it is a symptom and not a disease. Additionally, when treating insomnia, non-pharmacologic issues need consideration before initiating drug therapy. A variety of pharmacologic agents are available to treat insomnia short term. Recently, two new novel agents have been added to the armamentarium of drugs that have some advantages over older, traditional agents.


2016 ◽  
Vol 10 (5) ◽  
pp. 52-57
Author(s):  
Seyyede Zolaikha Hashemi Chashmi ◽  
Valiollah Dabidi Roshan ◽  
Sohail Azizi ◽  
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