Ferric iron transport system of Pseudomonas aeruginosa PAO1 that functions as the uptake pathway of a novel catechol-substituted cephalosporin, S-9096

1994 ◽  
Vol 40 (6) ◽  
pp. 892-897 ◽  
Author(s):  
Yoshinori Yamano ◽  
Tohru Nishikawa ◽  
Yoshihide Komatsu
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Transport System ◽  
Iron Transport ◽  
Ferric Iron ◽  
Pseudomonas Aeruginosa Pao1 ◽  
Uptake Pathway

scholarly journals Initial characterization of the ferric iron transport system of Corynebacterium diphtheriae.

1983 ◽  
Vol 155 (3) ◽  
pp. 1439-1442 ◽  
Author(s):  
L M Russell ◽  
R K Holmes
Keyword(s):  
Transport System ◽  
Iron Transport ◽  
Ferric Iron ◽  
Corynebacterium Diphtheriae ◽  
Initial Characterization

Influence of ferric iron on gene expression and rhamnolipid synthesis during batch cultivation of Pseudomonas aeruginosa PAO1

2014 ◽  
Vol 98 (15) ◽  
pp. 6725-6737 ◽  
Author(s):  
Anke Schmidberger ◽  
Marius Henkel ◽  
Rudolf Hausmann ◽  
Thomas Schwartz
Keyword(s):  
Gene Expression ◽  
Pseudomonas Aeruginosa ◽  
Ferric Iron ◽  
Batch Cultivation ◽  
Pseudomonas Aeruginosa Pao1

scholarly journals The mammalian transferrin-independent iron transport system may involve a surface ferrireductase activity

1994 ◽  
Vol 302 (3) ◽  
pp. 875-879 ◽  
Author(s):  
I Jordan ◽  
J Kaplan
Keyword(s):  
Transport System ◽  
Hela Cells ◽  
Iron Uptake ◽  
Iron Transport ◽  
Ferric Iron ◽  
Ferric Citrate ◽  
Ammonium Citrate ◽  
Transport Systems ◽  
Ferric Ammonium Citrate ◽  
Citrate Accumulation

Mammalian cells accumulate iron from ferric citrate or ferric nitrilotriacetate through the activity of a transferrin-independent iron transport system [Sturrock, Alexander, Lamb, Craven and Kaplan (1990) J. Biol. Chem. 265, 3139-3145]. The uptake system might recognize and transport ferric-anion complexes, or cells may reduce ferric iron at the surface and then transport ferrous iron. To distinguish between these possibilities we exposed cells to either [59Fe]ferric citrate or ferric [14C]citrate and determined whether accumulation of iron was accompanied by the obligatory accumulation of citrate. In HeLa cells and human skin fibroblasts the rate of accumulation of iron was three to five times greater than that of citrate. Incubation of fibroblasts with ferric citrate or ferric ammonium citrate resulted in an enhanced accumulation of iron and citrate; the molar ratio of accumulation approaching unity. A similar rate of citrate accumulation, however, was observed when ferric citrate-incubated cells were exposed to [14C]citrate alone. Further studies demonstrated the independence of iron and citrate accumulation: addition of unlabelled citrate to cells decreased the uptake of labelled citrate without affecting the accumulation of 59Fe; iron uptake was decreased by the addition of ferrous chelators whereas the uptake of citrate was unaffected; reduction of ferric iron by ascorbate increased the uptake of iron but had no effect on the uptake of citrate. When HeLa cells were depleted of calcium, iron uptake decreased, but there was little effect on citrate uptake. These results indicate that transport of iron does not require the obligatory transport of citrate and vice versa. The mammalian transferrin-independent iron transport system appears functionally similar to iron transport systems in both the bacterial and plant kingdoms which require the activities of both a surface reductase and a ferrous metal transporter.

scholarly journals Regulation of the transferrin-independent iron transport system in cultured cells.

1991 ◽  
Vol 266 (5) ◽  
pp. 2997-3004 ◽  
Author(s):  
J Kaplan ◽  
I Jordan ◽  
A Sturrock
Keyword(s):  
Transport System ◽  
Iron Transport ◽  
Cultured Cells
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