Defining the breakpoint of a multigene deletion in the immunoglobulin heavy chain gene cluster

1995 ◽  
Vol 41 (2-3) ◽  
Author(s):  
Zhi-Qiing Chen ◽  
MartenH. Hofker ◽  
DianeW. Cox
Keyword(s):  
Gene Cluster ◽  
Heavy Chain ◽  
Immunoglobulin Heavy Chain ◽  
Chain Gene ◽  
Heavy Chain Gene ◽  
Immunoglobulin Heavy Chain Gene

Tandem Repeats 3′ of the IGHA Genes in the Human Immunoglobulin Heavy Chain Gene Cluster

Genomics ◽  
1996 ◽  
Vol 35 (1) ◽  
pp. 189-195 ◽  
Author(s):  
Hakyung K. Kang ◽  
Diane W. Cox
Keyword(s):  
Gene Cluster ◽  
Heavy Chain ◽  
Tandem Repeats ◽  
Immunoglobulin Heavy Chain ◽  
Human Immunoglobulin ◽  
Chain Gene ◽  
Heavy Chain Gene ◽  
Immunoglobulin Heavy Chain Gene

Susceptibility to multiple sclerosis and the immunoglobulin heavy chain gene cluster

1998 ◽  
Vol 44 (6) ◽  
pp. 984-984 ◽  
Author(s):  
Robert Feakes ◽  
Jeremy Chataway ◽  
Stephen Sawcer ◽  
Hywel B. Jones ◽  
David Clayton ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gene Cluster ◽  
Heavy Chain ◽  
Immunoglobulin Heavy Chain ◽  
Chain Gene ◽  
Heavy Chain Gene ◽  
Immunoglobulin Heavy Chain Gene

Polymorphisms in canine immunoglobulin heavy chain gene cluster: a double‐edged sword for diabetes mellitus in the dog

2021 ◽  
Author(s):  
C. R. Sanz ◽  
N. Sevane ◽  
M. D. Pérez‐Alenza ◽  
M. Valero‐Lorenzo ◽  
S. Dunner
Keyword(s):  
Diabetes Mellitus ◽  
Gene Cluster ◽  
Heavy Chain ◽  
Immunoglobulin Heavy Chain ◽  
Chain Gene ◽  
Heavy Chain Gene ◽  
Immunoglobulin Heavy Chain Gene ◽  
Cluster A

An immunoglobulin heavy chain gene deletion at direct repeats: Nucleotide sequence and effect on mrna accumulation

1988 ◽  
Vol 25 (2) ◽  
pp. 181-187 ◽  
Author(s):  
Barry Kobrin ◽  
Kevin Glass ◽  
Sherie L. Morrison ◽  
Christine Milcarek
Keyword(s):  
Nucleotide Sequence ◽  
Heavy Chain ◽  
Gene Deletion ◽  
Immunoglobulin Heavy Chain ◽  
Chain Gene ◽  
Direct Repeats ◽  
Heavy Chain Gene ◽  
Immunoglobulin Heavy Chain Gene ◽  
Mrna Accumulation

scholarly journals Primary Malignant Lymphoma of the Brain: Mutation Pattern of Rearranged Immunoglobulin Heavy Chain Gene

2002 ◽  
Vol 93 (12) ◽  
pp. 1308-1316 ◽  
Author(s):  
Sumio Endo ◽  
Shu-Jing Zhang ◽  
Takafumi Saito ◽  
Mitsuo Kouno ◽  
Toshihiko Kuroiwa ◽  
...  
Keyword(s):  
Malignant Lymphoma ◽  
Heavy Chain ◽  
Immunoglobulin Heavy Chain ◽  
Chain Gene ◽  
Heavy Chain Gene ◽  
Immunoglobulin Heavy Chain Gene ◽  
Mutation Pattern ◽  
The Brain

A cloned human immunoglobulin heavy chain gene with a novel direct-repeat sequence in 5' flanking region

Gene ◽  
1985 ◽  
Vol 33 (2) ◽  
pp. 181-189 ◽  
Author(s):  
Kudo Akira ◽  
Ishihara Toshiki ◽  
Nishimura Yushi ◽  
Watanabe Takeshi
Keyword(s):  
Heavy Chain ◽  
Direct Repeat ◽  
Immunoglobulin Heavy Chain ◽  
Repeat Sequence ◽  
Human Immunoglobulin ◽  
Chain Gene ◽  
Heavy Chain Gene ◽  
Immunoglobulin Heavy Chain Gene ◽  
Direct Repeat Sequence ◽  
Flanking Region

Can Polymerase Chain Reaction Help Distinguish Benign From Malignant Lymphoid Aggregates in Bone Marrow Aspirates?

2000 ◽  
Vol 124 (4) ◽  
pp. 511-515
Author(s):  
Jonathan Ben-Ezra ◽  
Kirk Hazelgrove ◽  
Andrea Ferreira-Gonzalez ◽  
Carleton T. Garrett
Keyword(s):  
Bone Marrow ◽  
Polymerase Chain Reaction ◽  
Heavy Chain ◽  
Immunoglobulin Heavy Chain ◽  
Chain Gene ◽  
Heavy Chain Gene ◽  
Immunoglobulin Heavy Chain Gene ◽  
Chain Reaction ◽  
Polymerase Chain ◽  
Lymphoid Aggregates

Abstract Objective.—Although morphologic and immunologic clues are helpful in distinguishing benign from malignant lymphoid aggregates in bone marrow biopsies, there remain some cases in which it is not possible to arrive at a definitive diagnosis. Since the malignant aggregates are monoclonal B-cell proliferations, we sought to determine whether performing polymerase chain reaction for the immunoglobulin heavy-chain locus would be helpful in distinguishing these 2 entities. Methods and Results.—Scrapings from unstained bone marrow aspirate smears or touch preparations of bone marrow biopsies from 15 patients with benign bone marrow lymphoid aggregates and 18 patients with malignant lymphoid infiltrates were analyzed for rearrangements of the FR3 region of the immunoglobulin heavy-chain gene locus by a heminested polymerase chain reaction procedure. All specimens had amplifiable DNA, as shown by amplification of the ras proto-oncogene. None of the 15 cases of benign bone marrow lymphoid aggregates demonstrated clonality upon amplification of the immunoglobulin heavy-chain gene locus. In contrast, 8 of the 18 malignant samples were positive (P = .01 by χ2 test; sensitivity, 44%; specificity, 100%; positive predictive value, 100%; negative predictive value, 60%). There was a tendency for there to be more lymphocytes in stained bone marrow aspirate smears from the cases of malignant lymphoid aggregates with a positive polymerase chain reaction result than in those without demonstrable clonality (36.0 ± 35.4% vs 9.8 ± 8.0%, P = .13). Conclusions.—Polymerase chain reaction for the immunoglobulin heavy-chain gene locus may help distinguish benign from malignant bone marrow lymphoid aggregates. Although the presence of false-negative samples may be related to the relative lack of lymphocytes in the bone marrow aspirates, other factors, such as the lack of amplification of the FR3 region of the immunoglobulin heavy-chain gene locus in particular tumors, cannot be ruled out with certainty.

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