Prenatal expression of growth hormone receptor/binding protein and insulin-like growth factor-I (IGF-I) in the enamel organ

1994 ◽  
Vol 189 (6) ◽  
Author(s):  
B.K. Joseph ◽  
N.W. Savage ◽  
W.G. Young ◽  
M.J. Waters
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Receptor Binding ◽  
Hormone Receptor ◽  
Growth Hormone Receptor ◽  
Enamel Organ ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Igf I ◽  
Receptor Binding Protein

Hepatic expression of growth hormone receptor/binding protein and insulin-like growth factor I genes in uremic rats. Influence of nutritional deficit

1999 ◽  
Vol 9 (1) ◽  
pp. 61-68 ◽  
Author(s):  
Venancio Martı́nez ◽  
Milagros Balbı́n ◽  
Flor A. Ordóñez ◽  
Julián Rodrı́guez ◽  
Enrique Garcı́a ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Receptor Binding ◽  
Hormone Receptor ◽  
Growth Hormone Receptor ◽  
Insulin Like Growth Factor ◽  
Hepatic Expression ◽  
Factor I ◽  
Nutritional Deficit ◽  
Receptor Binding Protein

scholarly journals Control of ovine hepatic growth hormone receptor and insulin-like growth factor I by thyroid hormones in utero

2000 ◽  
Vol 278 (6) ◽  
pp. E1166-E1174 ◽  
Author(s):  
A. J. Forhead ◽  
J. Li ◽  
J. C. Saunders ◽  
M. J. Dauncey ◽  
R. S. Gilmour ◽  
...  
Keyword(s):  
Gene Expression ◽  
Growth Hormone ◽  
Growth Factor ◽  
Thyroid Hormones ◽  
Hormone Receptor ◽  
Growth Hormone Receptor ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Igf I ◽  
I Gene

By use of RNase protection assays, hepatic growth hormone receptor (GHR) and insulin-like growth factor I (IGF-I) mRNA abundances were measured in sheep fetuses after experimental manipulation of fetal plasma thyroid hormone concentrations by fetal thyroidectomy (TX) and exogenous infusion of triiodothyronine (T3) and cortisol. TX abolished the normal prepartum rise in hepatic GHR abundance but had little effect on hepatic GHR gene expression at 127–130 days (term 145 ± 2 days). By contrast, it upregulated basal IGF-I expression in immature fetal liver by increasing both Class 1 and Class 2 transcript abundance but had no further effects on IGF-I gene mRNA levels at 142–145 days. Raising plasma T3 to prepartum values by exogenous infusion of either T3 or cortisol into immature intact fetuses prematurely raised hepatic GHR and IGF-I mRNA abundances to values similar to those seen in intact fetuses at 142–145 days. In TX fetuses, cortisol infusion increased hepatic GHR mRNA but not total IGF-I mRNA abundance at 127–130 days. These findings show that thyroid hormones have an important role in the regulation of hepatic GHR and IGF-I gene expression in fetal sheep during late gestation and suggest that T3 mediates the maturational effects of cortisol on the hepatic somatotropic axis close to term.

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