Genetic predisposition and environmental factors leading to the development of insulin-dependent diabetes mellitus in Chilean children

1996 ◽  
Vol 74 (2) ◽  
pp. 105-109 ◽  
Author(s):  
F. Pérez-Bravo ◽  
E. Carrasco ◽  
M. D. Gutierrez-López ◽  
M. T. Martínez ◽  
G. López ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Environmental Factors ◽  
Genetic Predisposition ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Insulin Dependent

The Role of Genetic Predisposition to Type I (Insulin-Dependent) Diabetes Mellitus

1991 ◽  
Vol 23 (4) ◽  
pp. 427-435 ◽  
Author(s):  
Ingeborg Deschamps ◽  
Jean P. Beressi ◽  
Iman Khalil ◽  
Jean J. Robert ◽  
Jacques Hors
Keyword(s):  
Diabetes Mellitus ◽  
Genetic Predisposition ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Type I ◽  
Insulin Dependent

Interaction of genetic and environmental factors in the pathogenesis of insulin-dependent diabetes mellitus

1997 ◽  
Vol 257 (2) ◽  
pp. 143-156 ◽  
Author(s):  
Hans K Åkerblom ◽  
Mikael Knip ◽  
Heikki Hyöty ◽  
Helena Reijonen ◽  
Suvi Virtanen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Environmental Factors ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Insulin Dependent ◽  
Genetic And Environmental Factors

scholarly journals Medicogenetic counseling and prediction of insulin-dependent diabetes mellitus

1996 ◽  
Vol 42 (6) ◽  
pp. 3-8
Author(s):  
T. L. Kuraeva ◽  
O. V. Remizov ◽  
I. I. Dedov
Keyword(s):  
Diabetes Mellitus ◽  
B Cells ◽  
Genetic Predisposition ◽  
Genetic Factors ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Process Stage ◽  
Complete Destruction ◽  
Insulin Dependent

Insulin-dependent diabetes mellitus (IDDM) is a genetically determined disease, in the mechanisms of which autoimmune processes are leading, leading to disruption of insulin production. At present, quite convincing data have been accumulated testifying to the importance of genetic factors in the development of IDDM. Their contribution to the development of the disease (heritability coefficient) is 0.6-0.7, if we take the complete dependence of the development of IDDM on genetic factors as 1.0. The realization of a genetic predisposition in many respects depends on environmental influences that are not yet fully understood. In the development of IDDM, 6 stages are distinguished: stage 1 - a genetic predisposition, stage 2 - a hypothetical starting moment, stage 3 - an active autoimmune process, stage 4 - a decrease in insulin secretion in response to glucose intake, 5 stage I - clinical manifestation, which develops after the death of 80-90% of b-cells, and stage 6 - complete destruction of b-cells. Complete destruction of b-cells, according to some authors, occurs after 5 years or more. Since the development of IDDM is, as a rule, a long multi-stage process that sharply manifests itself at some point, in recent years attempts have been made to predict the development of the disease and verify the asymptomatic preclinical period.

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