scholarly journals Genetic influence of the R/Q353 genotype on factor VII activity is overwhelmed by environmental factors in Chinese patients with Type II (non-insulin-dependent) diabetes mellitus

Diabetologia ◽  
1998 ◽  
Vol 41 (7) ◽  
pp. 760-766 ◽  
Author(s):  
K. S. L. Lam ◽  
O. C. K. Ma ◽  
C. Bourke ◽  
L. C. Chan ◽  
E. D. Janus
Keyword(s):  
Diabetes Mellitus ◽  
Environmental Factors ◽  
Insulin Dependent Diabetes Mellitus ◽  
Genetic Influence ◽  
Insulin Dependent Diabetes ◽  
Chinese Patients ◽  
Factor Vii ◽  
Dependent Diabetes Mellitus ◽  
Type Ii ◽  
Insulin Dependent

Evaluation of the dietetic indicators of patients with type II (non-insulin-dependent) diabetes mellitus

2000 ◽  
Vol 50 ◽  
pp. 240
Author(s):  
Maria Matilde Socarrás Súarez ◽  
Jorge Blanco Anesto ◽  
Armando Rodríguez Súarez ◽  
Daris Gonzalez Hernández ◽  
Frank Fernandez ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Type Ii ◽  
Insulin Dependent

Factor VII Gene Polymorphisms, Factor VII:C Levels and Features of Insulin Resistance in Non-Insulin-Dependent Diabetes mellitus

1996 ◽  
Vol 75 (03) ◽  
pp. 401-406 ◽  
Author(s):  
Daniella M Heywood ◽  
Michael W Mansfield ◽  
Peter J Grant
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Insulin Dependent Diabetes Mellitus ◽  
Multiple Regression Model ◽  
Base Change ◽  
Insulin Dependent Diabetes ◽  
Factor Vii ◽  
Dependent Diabetes Mellitus ◽  
Insertion Polymorphism ◽  
Insulin Dependent

SummaryThe macrovascular complications of non-insulin-dependent diabetes mellitus (NIDDM) are related to the features of insulin resistance (IR). High Factor VII :C (FVII:C) levels are associated with increased cardiovascular risk and relate to a base change in the FVII gene detected by Msp I endonuclease, and also to an insertion polymorphism in the promoter region. To examine the association between FVII:C levels, genotype and features of IR, 95 NIDDM patients were studied. Genotype was related to FVII:C levels (M1M1 137%, n = 75; M1M2 and M2M2 114%, n = 20, p <0.005; AA 136%, n = 71; Aa 119%, n = 21, p <0.05), which is consistent with previous studies in healthy populations. FVII: C correlated with cholesterol (r = 0.51, p <0.0005), insulin (r = 0.36, p = 0.002), triglycerides (r = 0.34, p = 0.001), age (r = 0.23, p <0.005) and body mass index (r = 0.23, p <0.05). When analysed by Msp I genotype, the stronger predictor of FVII: C levels, these correlations remained, with no difference in regression slopes. In a multiple regression model, genotype, cholesterol, insulin, and gender remained as independent predictors of FVII:C levels. In conclusion, FVII :C concentrations are elevated in NIDDM in relation to both FVII genotypes and features of IR.

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