Ultrastructural studies on the secretory cycle of the neurosecretory cells and the formation of herring bodies in the paraventricular nucleus of the rat

1977 ◽  
Vol 177 (1) ◽  
Author(s):  
Yasue Yukitake ◽  
Yutaka Taniguchi ◽  
Kazumasa Kurosumi
Keyword(s):  
Paraventricular Nucleus ◽  
Neurosecretory Cells ◽  
Secretory Cycle ◽  
Ultrastructural Studies ◽  
Herring Bodies

A Slow Transient Potassium Current Expressed in a Subset of Neurosecretory Neurons of the Hypothalamic Paraventricular Nucleus

2000 ◽  
Vol 84 (4) ◽  
pp. 1814-1825 ◽  
Author(s):  
Jason A. Luther ◽  
Katalin Cs. Halmos ◽  
Jeffrey G. Tasker
Keyword(s):  
Paraventricular Nucleus ◽  
Potassium Current ◽  
Outward Current ◽  
Retrograde Transport ◽  
Neurosecretory Cells ◽  
Firing Frequency ◽  
Hypothalamic Paraventricular Nucleus ◽  
Transient Outward Current ◽  
Type I ◽  
Double Labeling

Type I putative magnocellular neurosecretory cells of the hypothalamic paraventricular nucleus (PVN) express a prominent transient outward rectification generated by an A-type potassium current. Described here is a slow transient outward current that alters cell excitability and firing frequency in a subset of type I PVN neurons (38%). Unlike most of the type I neurons (62%), the transient outward current in these cells was composed of two kinetically separable current components, a fast activating, fast inactivating component, resembling an A-type potassium current, and a slowly activating [10–90% rise time: 20.4 ± 12.8 (SE) ms], slowly inactivating component (time constant of inactivation: τ = 239.0 ± 66.1 ms). The voltage dependence of activation and inactivation and the sensitivity to block by 4-aminopyridine (5 mM) and tetraethylammonium chloride (10 mM) of the fast and slow components were similar. Compared to the other type I neurons, the neurons that expressed the slow transient outward current were less excitable when hyperpolarized, requiring larger current injections to elicit an action potential (58.5 ± 13.2 vs. 15.4 ± 2.4 pA; 250-ms duration; P < 0.01), displaying a longer delay to the first spike (184.9 ± 15.7 vs. 89.7 ± 8.8 ms with 250- to 1,000-ms, 50-pA current pulses; P < 0.01), and firing at a lower frequency (18.7 ± 4.6 vs. 37.0 ± 5.5 Hz with 100-pA current injections; P < 0.05). These data suggest that a distinct subset of type I PVN neurons express a novel slow transient outward current that leads to a lower excitability. Based on double labeling following retrograde transport of systemically administered fluoro-gold and intracellular injection of biocytin, these cells are neurosecretory and are similar morphologically to magnocellular neurosecretory cells, although it remains to be determined whether they are magnocellular neurons.

scholarly journals Facilitatory influence of noradrenergic afferents on the excitability of rat paraventricular nucleus neurosecretory cells.

1984 ◽  
Vol 355 (1) ◽  
pp. 237-249 ◽  
Author(s):  
T A Day ◽  
A V Ferguson ◽  
L P Renaud
Keyword(s):  
Paraventricular Nucleus ◽  
Neurosecretory Cells

Monoamines and peptidergic gomori-positive neurosecretory cells of the paraventricular nucleus of the rat hypothalamus during chronic alcohol consumption

1986 ◽  
Vol 102 (6) ◽  
pp. 1692-1694
Author(s):  
M. S. Kostantinova ◽  
E. A. Gromova ◽  
N. V. Bobkova ◽  
A. L. Polenov ◽  
L. A. Plakkhinas ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Paraventricular Nucleus ◽  
Neurosecretory Cells ◽  
Chronic Alcohol ◽  
Chronic Alcohol Consumption ◽  
Rat Hypothalamus

Neuropeptide FF (NPFF) control of magnocellular neurosecretory cells of the rat hypothalamic paraventricular nucleus (PVN)

Peptides ◽  
2006 ◽  
Vol 27 (5) ◽  
pp. 973-979 ◽  
Author(s):  
Jack H. Jhamandas ◽  
David MacTavish ◽  
Kim H. Harris
Keyword(s):  
Paraventricular Nucleus ◽  
Neurosecretory Cells ◽  
Hypothalamic Paraventricular Nucleus ◽  
Neuropeptide Ff

scholarly journals Centrally administered neuropeptide W-30 activates magnocellular neurosecretory cells in the supraoptic and paraventricular nuclei with neurosecretion in rats

2006 ◽  
Vol 190 (2) ◽  
pp. 213-223 ◽  
Author(s):  
Makoto Kawasaki ◽  
Tatsushi Onaka ◽  
Masamitsu Nakazato ◽  
Jun Saito ◽  
Takashi Mera ◽  
...  
Keyword(s):  
Paraventricular Nucleus ◽  
Arginine Vasopressin ◽  
Supraoptic Nucleus ◽  
Neurosecretory Cells ◽  
Hybridization Histochemistry ◽  
Paraventricular Nuclei ◽  
Fos Protein ◽  
Regulation Of Secretion ◽  
Plasma Arginine

We examined the effects of i.c.v. administration of neuro-peptide W-30 (NPW30) on plasma arginine vasopressin (AVP) and plasma oxytocin (OXT) using RIA. The induction of c-fos mRNA, AVP heteronuclear (hn)RNA, and c-Fos protein (Fos) in the supraoptic nucleus (SON) and paraventricular nucleus (PVN) of rats were also investigated using in situ hybridization histochemistry for c-fos mRNA and AVP hnRNA, and immunohistochemistry for Fos. Both plasma AVP and OXT were significantly increased at 5 and 15 min after i.c.v. administration of NPW30 (2.8 nmol/rat). In situ hybridization histochemistry revealed that the induction of c-fos mRNA and AVP hnRNA in the SON and PVN were significantly increased 15, 30, and 60 min after i.c.v. administration of NPW30 (1.4 nmol/rat). Dual immunostaining for Fos/AVP and Fos/OXT revealed that both AVP-like immunoreactive (LI) cells and OXT-LI cells exhibited nuclear Fos-LI in the SON and PVN, 90 min after i.c.v. administration of NPW30 (2.8 nmol/rat). These results suggest that central NPW30 may be involved in the regulation of secretion of AVP and OXT in the magnocellular neurosecretory cells in the SON and PVN.

γ-Aminobutyric acid antagonist blocks baroreceptor-activated inhibition of neurosecretory cells in the hypothalamic paraventricular nucleus of rats

1987 ◽  
Vol 81 (3) ◽  
pp. 319-324 ◽  
Author(s):  
M. Kasai ◽  
T. Osaka ◽  
K. Inenaga ◽  
H. Kannan ◽  
H. Yamashita
Keyword(s):  
Paraventricular Nucleus ◽  
Neurosecretory Cells ◽  
Hypothalamic Paraventricular Nucleus ◽  
Aminobutyric Acid ◽  
Acid Antagonist
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